From the user's perspective, MDP is a collection of supervised and unsupervised learning algorithms and other data processing units that can be combined into data processing sequences and more complex feed-forward network architectures.
ITK is a powerful open-source toolkit implementing state-of-the-art algorithms in medical image processing and analysis. MATLAB, on the other hand, is well-known for its easy-to-use, powerful prototyping capabilities that significantly improve productivity. With the help of MATITK, biomedical image computing researchers familiar with MATLAB can harness the power of ITK algorithms while avoiding learning C++ and dealing with low-level programming issues.