Gaining awareness of psychosis (i.e., insight) is linked to depression, particularly in the post-acute phase of psychosis. Informed by social rank theory, we examined whether the insight–depression relationship is explained by reduced social rank related to psychosis and whether self-compassion (including uncompassionate self-responding [UCS] and compassionate self-responding [CSR]) and mindfulness buffered the relationship between social rank and depression in individuals with first episode psychosis during the post-acute phase.
Postpartum depression (PPD) is a common perinatal complication with adverse maternal and infant outcomes. This study investigated the efficacy and safety of zuranolone, a positive allosteric modulator of synaptic and extrasynaptic GABAA receptors and neuroactive steroid, as an oral, once-daily, 14-day treatment course for patients with severe PPD. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The review showed that robust evidence for the effectiveness of iCBT as an add-on to TAU is still limited, with results not necessarily generalisable to people from different backgrounds based on age, gender, education, and mental healthcare settings. Clearly more research is needed, as remotely delivered, self-guided iCBT has the promise to increase accessibility and be more cost-effective.
The findings suggest the involvement of both innate and adaptive immune cells in the development of depression.
Identifying dysfunctional immune cell subsets could help select patients with depression who show signs of immune dysfunction for future immunotherapy trials. However, further studies are needed to understand causality and how immune cell dysfunction relates to cytokine and neurotransmitter dysregulation.
To manage ‘treatment-resistant depression’, research has demonstrated that a multidisciplinary approach should be utilised (i.e., administration of medication as well as psychological support). In the current study, psilocybin was administered during a single session of psychological support. More research needs to be conducted to investigate the effectiveness of using psilocybin alongside a course of psychological support (e.g., Cognitive Behavioural Therapy).