This study aimed to explore the applicability of SCT in and possible approaches to improving symptom appraisal and help-seeking of patients with ARDs, one of the key barriers to earlier diagnosis. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
While there are still many unknowns that necessitate additional investigation, this article offers updated guidance to clinicians for enhancing clinical outcomes in immunocompromised populations with COVID-19. Open access article - no login required.
This editorial discusses new clinical practice guidelines by the American College of Rheumatology and American Academy of Hip and Knee Surgeons. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This effort aimed to develop evidence-based and consensus-based points to consider to assist clinicians in optimising decision-making in the early stages of diagnosis, treatment and monitoring of HLH/MAS. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
To understand the roles of serum exosomes in rheumatoid arthritis (RA), we comprehensively investigated the protein profiles of serum exosomes in patients with RA. Open Access
To perform a comprehensive evaluation of and identify correlates for physical fitness in consecutive patients with juvenile idiopathic arthritis (JIA) diagnosed in the era of biologics; also to compare the results with those obtained in healthy controls. You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
To examine the association between gout severity and socioeconomic status (SES) and gout severity and work absence. To read the full article, log in using your NHS OpenAthens details.
The objective was to identify longitudinal predictors of discordance between patients with rheumatoid arthritis (RA) and their health care providers, where patient global assessment of disease activity is substantially higher than provider global assessment. To read the full article, log in using your NHS OpenAthens details.
To investigate the cost‐effectiveness (cost‐utility) of introducing general practitioner screening for anxiety and depression in patients consulting for osteoarthritis (OA). To read the full article, log in using your NHS OpenAthens details.
Objectives Mast cells (MCs) are involved in the pathogenesis of rheumatoid arthritis (RA). However, their contribution remains controversial. To establish their role in RA, we analysed their presence in the synovium of treatment-naïve patients with early RA and their association and functional relationship with histological features of synovitis.
Methods Synovial tissue was obtained by ultrasound-guided biopsy from treatment-naïve patients with early RA (n=99). Immune cells (CD3/CD20/CD138/CD68) and their relationship with CD117+MCs in synovial tissue were analysed by immunohistochemistry (IHC) and immunofluorescence (IF). The functional involvement of MCs in ectopic lymphoid structures (ELS) was investigated in vitro, by coculturing MCs with naïve B cells and anticitrullinated protein antibodies (ACPA)-producing B cell clones, and in vivo in interleukin-27 receptor alpha (IL27ra)-deficient and control mice during antigen-induced arthritis (AIA).
Results High synovial MC counts are associated with local and systemic inflammation, autoantibody positivity and high disease activity. IHC/IF showed that MCs reside at the outer border of lymphoid aggregates. Furthermore, human MCs promote the activation and differentiation of naïve B cells and induce the production of ACPA, mainly via contact-dependent interactions. In AIA, synovial MC numbers increase in IL27ra deficient mice, in association with ELS and worse disease activity. To read the full article, log in using your NHS OpenAthens details.
This article discusses the current understanding of genetic heritability and challenges in the diagnosis of rheumatic diseases and how this field may develop in the future. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This retrospective matched cohort study evaluates lung cancer risk in rheumatoid arthritis and RA-interstitial lung disease. Open access article - no login required.