To determine whether infrapatellar fat pad (IPFP) signal intensity measures are predictive of incident radiographic osteoarthritis (ROA) over 4 years in the Osteoarthritis Initiative study. To read the full article, log in using your NHS OpenAthens details.
To determine whether obesity in women with systemic lupus erythematosus (SLE) is independently associated with worse patient‐reported outcomes (PROs). Data were derived from a prospective study of adult women with a diagnosis of SLE that was verified by medical record review. To read the full article, log in using your NHS OpenAthens details.
The aims of the present study were: (a) to identify the incidence of osteoarthritis (OA) after a traumatic knee injury; (b) identify the risk of post‐traumatic osteoarthritis (PTOA) based on the type of injury; and (c) identify the time from injury to OA diagnosis. To read the full article, log in using your NHS OpenAthens details.
Tender joint count (TJC) is included in Composite Disease Activity Scores (CDAS) (DAS28/CDAI/SDAI). The impact of having predominantly tender joints was explored by use of the Tender‐Swollen Joint count Difference (TSJD). Ultrasound (US) provides a measure of joint inflammation. The present study aimed to explore the cross‐sectional and longitudinal associations between TSJD and a spectrum of outcome measures including US scores in patients with established rheumatoid arthritis (RA) during follow‐up on bDMARD treatment. To read the full article, log in using your NHS OpenAthens details.
To assess structural progression in knees with no/mild radiographic osteoarthritis (OA) (i.e., Kellgren/Lawrence [K/L] grades 0–2) that will undergo knee replacement during a 5‐year period; to assess differences in structural damage on magnetic resonance imaging (MRI) in knees with no/mild radiographic OA versus those with severe radiographic OA (i.e., K/L grades 3 and 4) at baseline; and to assess differences in pain levels between those groups. To read the full article, log in using your NHS OpenAthens details.
Meniscal tears often accompany knee osteoarthritis, a disabling condition affecting 14 million individuals in the United States. While several randomized controlled trials have compared physical therapy to surgery for individuals with knee pain, meniscal tear, and osteoarthritic changes (determined via radiographs or magnetic resonance imaging), no trial has evaluated the efficacy of physical therapy alone in these subjects. Open Access.
To compare mortality rates, underlying causes of death, excess mortality, and years of potential life lost (YPLL) among patients with rheumatoid arthritis (RA) relative to the general population. Open Access
Previous studies suggest that RA activity is sensitive to seasonal changes. This study explored the influence of season on RA activity, particularly the distribution of affected joints, using a nationwide database in Japan. Open Access
Analysis of the randomised trials provides moderate- to low-quality evidence that exercise slightly improved pain and function and gave small improvements in depression, social function and people’s belief in their physical capability.
Patient interviews highlight a common misconception that exercise can do more harm than good, and the important role healthcare professionals play in challenging these beliefs. Programmes that include clear, tailored instruction and provide opportunities to participate in supervised or group exercise may improve exercise uptake in people with hip and/or knee osteoarthritis.
To determine the proportion of primary lipid screening among patients with rheumatoid arthritis (RA) and compare it with patients with diabetes mellitus (DM) and patients with neither RA nor DM. To determine whether primary lipid screening varied according to the healthcare provider (rheumatologist vs. non‐rheumatologist). To read the full article, log in using your NHS OpenAthens details.
Question Which is the best strategy to achieve (drug-free) inactive disease in juvenile idiopathic arthritis (JIA)?
Methods In a randomised, single-blinded, study in disease-modifying anti-rheumatic drug (DMARD)-naive patients with JIA, three treatment-strategies were compared: (1) sequential DMARD-monotherapy (sulfasalazine or methotrexate (MTX)), (2) combination therapy MTX + 6 weeks prednisolone and (3) combination therapy MTX +etanercept. Treatment-to-target entailed 3-monthly DMARD/biological adjustments in case of persistent disease activity, with drug tapering to nil in case of inactive disease.
After 24 months, primary outcomes were time-to-inactive-disease and time-to-flare after DMARD discontinuation. Secondary outcomes were adapted ACRPedi30/50/70/90 scores, functional ability and adverse events. To read the full article, log in using your NHS OpenAthens details.
To identify novel DNA methylation sites significant for rheumatoid arthritis (RA) and comprehensively understand their underlying pathological mechanism.To read the full article, log in using your NHS OpenAthens details.
We explored factors associated with pain and its severity in a population cohort of young people with bilateral cerebral palsy, comparing parent/carer and young people self‐reports.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
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To compare foot and ankle mobility, foot posture and dynamic knee valgus, measured as the frontal plane projection angle (FPPA) during single-leg squatting, between individuals with and without PFOA. To read the full article, log in using your NHS OpenAthens details.
Controlled immune responses rely on integrated crosstalk between cells and their microenvironment. We investigated whether targeting proinflammatory signals from the extracellular matrix that persist during pathological inflammation provides a viable strategy to treat rheumatoid arthritis (RA). Open Access
Hydroxychloroquine (HCQ) benefits metabolic and cardiovascular outcomes in patients with rheumatoid arthritis (RA), but its efficacy appears to be moderate as compared to placebo. The aim of our study was to assess the current literature on the clinical and structural efficacy of HCQ for joints in RA patients. To read the full article, log in using your NHS OpenAthens details.
To obtain the perspective of individuals with systemic lupus erythematosus (SLE) regarding the role of poverty, neighborhood, and chronic stress in SLE outcomes. To read the full article, log in using your NHS OpenAthens details.