This study aimed to establish a population pharmacokinetic model for long-term HCQ treatment in patients with rheumatic diseases and to identify the factors influencing HCQ metabolism. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study aims to assess the correlation between the second metacarpal cortical index (2MCI) and bone mineral density (BMD) in rheumatoid arthritis patients, and to evaluate machine learning models utilizing 2MCI and clinical parameters for predicting osteoporosis/osteopenia presence and BMD. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study evaluates current practice relating to bone health in adult patients with inflammatory idiopathic myopathies in the United Kingdom and Hong Kong. Open access article - no login required.
This review explores the various pathophysiological mechanisms involved in statin-associated muscle symptoms and understand the difference between self-limited toxic myopathy and immune-mediated myopathy requiring immunomodulatory therapy. Open access article - no login required.
The aim of this commentary is to discuss the Cochrane Review “Exercise therapy for treatment of acute non-specific low back pain” by IJzelenberg et al. Open access article - no login required.
This UK study investigated the temporal association between first diagnosis of gout and cardiovascular events in the short-term. It found a short-term increased risk of cardiovascular events in the 30 days following the first consultation at which gout was diagnosed. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study assessed the efficacy and safety of intravenous secukinumab for the treatment of adults with active axial spondyloarthritis in INVIGORATE-1. It found IV secukinumab was effective for the treatment of adults with active axSpA over 52 weeks. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study investigates the relationship between weight loss rate following the initiation of anti-obesity medications and the risk of incident gout and recurrent gout flares among overweight/obese individuals. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study compares the effectiveness of Janus kinase inhibitors and biologic disease-modifying anti-rheumatic drugs on pain in patients with rheumatoid arthritis. Open access article - no login required.
To assess the global and regional burden, long-term trends, and potential risk factors of vaccines-associated six types of rheumatic diseases (ankylosing spondylitis, polymyalgia rheumatica, rheumatoid arthritis, Sjögren's syndrome, Systemic lupus erythematosus, Systemic scleroderma), this study conducted disproportionality analysis based on the reports from the World Health Organization International Pharmacovigilance Database documented between 1967 and 2023 across 156 countries and territories. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study indicates that there is no significant association between the use of hydroxychloroquine and the risk of osteoporosis in patients with rheumatoid arthritis. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The paper concludes that optimal management of patients presenting with PsO, AAU, IBD, and undiagnosed chronic back pain should include referral to a rheumatologist. Conducting MRI in all patients enhances diagnostic accuracy. Open access article - no login required.
This study aimed to investigate the association of bisphosphonates with outcomes related to radiographic changes and pain in hip osteoarthritis over 4 years. Open access article - no login required.
This retrospective matched cohort study evaluates lung cancer risk in rheumatoid arthritis and RA-interstitial lung disease. Open access article - no login required.
This study found a potential causal association between educational attainment and rheumatoid arthritis, systemic lupus erythematosus, emphasizing the need for further investigation and potential integration of educational attainment into clinical practice to enhance treatment strategies. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study investigates the overall and sex-specific relationship between presence and severity of knee osteoarthritis with muscle composition, power, and energetics in older adults. Open access article - no login required.
This item provides evidence-based recommendations regarding screening for interstitial lung disease (ILD) and the monitoring for ILD progression in people with systemic autoimmune rheumatic diseases (SARDs), specifically rheumatoid arthritis, systemic sclerosis, idiopathic inflammatory myopathies, mixed connective tissue disease, and Sjögren disease. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This item provides evidence-based recommendations regarding the treatment of interstitial lung disease in adults with systemic autoimmune rheumatic diseases. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
To develop a non-linear mixed-effects population pharmacokinetic and pharmacodynamic (PK-PD) model describing the change in the concentration of methotrexate polyglutamates in erythrocytes (ery-MTX-PGn with “n” number of glutamate, representing PK component) and how this relates to modified 28-joint Disease Activity Score incorporating erythrocyte sedimentation rate (DAS-28-3) for rheumatoid arthritis (RA), representing PD component. Open access article - no login required
The primary objective of this study was to evaluate the impact of the IL-6 inhibitor olokizumab on the pharmacokinetics of CYP probe substrates in subjects with active RA. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This cross-sectional study investigates the complex association between the oxidative balance score and rheumatoid arthritis in US adults. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Accurate measurement of disease activity in systemic sclerosis remains a significant clinical challenge. The Scleroderma Clinical Trials Consortium convened an Activity Index Working Group to develop a novel measure of disease activity. Open access article - no login required.
This study evaluated the cardiovascular risk of long-term glucocorticoid use by studying patients on stable disease modifying anti-rheumatic drugs (DMARDs). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study aims to evaluate the efficacy and acceptability of the novel electrical therapy on sleep disturbance in autoimmune rheumatism diseases patients and its effect on immunologic factors. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study sought to determine the impact of hydroxychloroquine dose on the risk of hospitalizations for systemic lupus erythematosus. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study reports a low occurrence of new-onset SAIDs following COVID-19 vaccination, primarily IIMs, PMR, and inflammatory arthritis. Identified risk factors included pre-existing AID multimorbidity, mental health diseases, and mixed race. Open access article - no login required.
This study concludes that febuxostat combined with a low-purine diet can reduce inflammatory factors and alleviate the degree of pain in gout patients, significantly improving their clinical symptoms. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This item concludes that a higher exposure to glucocorticoids during the initial therapy of lupus nephritis was associated with better renal outcomes, at the cost of increased infections and mortality. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study aimed to utilize Mendelian randomization (MR) methods to investigate the potential causal relationship between autoimmune liver disease and Sjogren's syndrome. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study investigates the clinical features of patients with rheumatic and musculoskeletal diseases (RMDs) infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the relationship between RMDs relapse and SARS-CoV-2 infection. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study uses UK Biobank data to reveal a positive correlation between accelerated biological aging, as measured by biological age accelerations, and the susceptibility to rheumatoid arthritis. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study aimed to explore the hotspots of miRNA research related to RA published from different countries, organizations, and authors. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The study demonstrates the potential of integrating traditional biomarkers with unsupervised clustering algorithms in understanding the heterogeneity of AoSD. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study investigates the linkage of matrix metalloproteinase (MMP) gene polymorphisms with the pathogenesis of knee osteoarthritis (OA). Open access article - no login required.
This study aims to evaluate the long-term efficacy, safety, and cumulative retention rate of antitumor necrosis factor-alpha (anti-TNF-α) therapy for patients with Behcet's uveitis (BU) using meta-analysis. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This article discusses the current understanding of genetic heritability and challenges in the diagnosis of rheumatic diseases and how this field may develop in the future. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Osteoarthritis (OA), rheumatoid arthritis (RA), and psoriatic arthritis (PsA) can all lead to the formation of bony proliferations (BP). This systematic review aimed to examine the characteristics of BPs in patients with RA, PsA, OA, and healthy controls (HC), and examined any treatment-related effect on BP number and size. Open access article - no login required.
This systematic review aimed to evaluate the extent of measurable and nonmeasurable factors in patients with rheumatoid arthritis and their satisfaction with this method of care. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This meta-analysis was performed to evaluate the clinical outcomes in rheumatoid arthritis patients with COVID-19. Our data suggests that RA patients had an increased risk of adverse clinical outcomes with COVID-19 infection. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Two years after trial termination, vitamin D 2000 IU/day's protective effects dissipated, but 1000 mg/day n-3 fatty acids had a sustained effect in reducing AD incidence. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
While there are still many unknowns that necessitate additional investigation, this article offers updated guidance to clinicians for enhancing clinical outcomes in immunocompromised populations with COVID-19. Open access article - no login required.
This systematic review investigates what is known about the positive and negative predictors of outcomes in patients with osteoarthritis who undergo intra‐articular corticosteroid injections. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This editorial looks at therapeutic drugs for gout. Although various therapies are available for gout treatment, the target of healing gout is often not achieved. Gout treatment often requires long-term medication, drug safety requires special attention. Open access article - no login required.
This study investigates the effect of an intensive dietary intervention on body weight and clinical measures of gout severity in individuals with obesity and gout. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This article incorporates and evaluates public and health professional involvement in a mixed methods review of occupational therapy for self-management of rheumatoid arthritis (RA). Open access article - no login required.
Uveitis is a common extra-articular manifestation of axial spondylarthritis (AxSpA). We set to evaluate risk of anterior uveitis (AU) with biologics and synthetic disease-modifying drugs in AxSpA. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study examines whether a mobile health patient reported outcome app integrated in the electronic health record (EHR) can reduce visit volume for rheumatoid arthritis. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This population-based study investigated the incidence and factors associated with mental illness among patients with rheumatoid arthritis receiving b/tsDMARDs. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The aim of this study was to assess the correlation between adherence assessed with a Medication Event Monitoring System (MEMS) versus pill count, MTX-polyglutamate (PG) concentration and Compliance-Questionnaire-Rheumatology (CQR) in patients with established rheumatoid arthritis. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
We aimed to examine the relation of the rate of weight loss induced by antiobesity medications over one year to all-cause mortality among patients with overweight or obesity and knee or hip OA. Open access article - no login required.
This article aims to evaluate the risk of all-cause, specific mortality among patients with fibromyalgia, which is a controversial topic. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The current study aims to assess the efficacy of baricitinib in treating SLE patients. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study aims to assess the association of obesity and CRP concentrations in adult patients with rheumatoid arthritis (RA), and its influence on measures of disease activity. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This summary is based on a Cochrane review previously published in the Cochrane Database of Systematic Reviews. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This guideline updates recommendations for prevention and treatment of glucocorticoid-induced osteoporosis (GIOP) for patients with rheumatic or nonrheumatic conditions receiving >3 months treatment with glucocorticoids (GCs) ≥2.5 mg daily. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study attempts to address an unmet area in myositis and pain research, and highlights the multidimensional and often overlooked area of pain perception in research. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The objective of this study is to summarize the available evidence, through meta-analysis, on the pain relief, quality of life, sleep improvement, and emotion regulation of fibromyalgia syndrome in traditional Chinese exercise, including Taichi. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study aimed to explore the applicability of SCT in and possible approaches to improving symptom appraisal and help-seeking of patients with ARDs, one of the key barriers to earlier diagnosis. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The present study aims to measure the effect of the Mediterranean diet (MedDiet) on the disease activity scores (DAS28) among patients with rheumatoid arthritis. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This guideline provides evidence-based recommendations regarding the optimal timing of TJA in patients who have symptomatic and radiographic moderate-to-severe osteoarthritis or advanced symptomatic osteonecrosis with secondary arthritis for whom nonoperative therapy was ineffective. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This randomized, controlled, mechanistic trial was designed to assess CBT's effects on pain catastrophizing and its underlying brain circuitry. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
There have been major changes in the classification and treatment of patients with idiopathic inflammatory myositis (IIM) in the last 2 decades. Here, we have longitudinally followed a well-characterized cohort of IIM patients in a rheumatology center and reported the outcome using the validated tools. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This item assesses the efficacy and safety of arthroscopic surgery associated with platelet-rich plasma (PRP) infusion in treating knee osteoarthritis (KOA). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
To address sub-optimal cardiovascular risk prediction in patients with psoriatic disease (PsD), we developed and internally validated a 5-year disease-specific cardiovascular risk prediction model. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Research has shown that empathy for both somatic and psychological pain recruits affective components of the so-called pain matrix, a set of brain regions that is activated during the perception of somatic pain. In addition, the subjective evaluation of experimentally induced somatic pain is related to empathy for somatic pain. In contrast, it is unclear whether or not the subjective sensitivity to somatic pain impacts on empathy for psychological pain.
In this article we review the pathogenesis and clinical features of the different TMA-causing conditions. We outline a practical approach to diagnosis and management and discuss empiric and disease-specific treatment strategies. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
We aimed to develop a risk prediction model for the development of PsA and to assess its performance among patients with psoriasis. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study investigates the impact of high-dose glucocorticoid therapy on sarcopenia in hospitalized patients with rheumatic musculoskeletal diseases (RMDs). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The item concludes that, in children and adolescents with ERA and JPsA, secukinumab demonstrated significantly longer time to flare and number of flares versus placebo. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Old age and glucocorticoid (GC) use increase the susceptibility to infection in patients with rheumatoid arthritis (RA). Accordingly, we investigated whether GC discontinuation reduces the incidence of infection in older adults with RA and analyzed factors associated with GC discontinuation. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This effort aimed to develop evidence-based and consensus-based points to consider to assist clinicians in optimising decision-making in the early stages of diagnosis, treatment and monitoring of HLH/MAS. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This editorial discusses new clinical practice guidelines by the American College of Rheumatology and American Academy of Hip and Knee Surgeons. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This editorial looks at negative results of a clinical trial featured in this issue, alongside previous, more positive studies of VNS. They discussed questions raised by the topic. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study evaluated the influence of sarcopenia, especially muscle quality, on outcomes of antineutrophil cytoplasmic antibody-associated vasculitis (AAV). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study investigates whether baseline joint space narrowing (JSN) predicted disease remission, knee pain, and physical function changes in persons with knee osteoarthritis (OA). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The objective of this study is to explore the performance and effect of dual-energy computed tomography (CT) and ultrasound in the diagnosis of gouty arthritis and to provide a reference for the clinical diagnosis of gouty arthritis. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Interstitial lung disease (ILD) is a frequent complication of rheumatoid arthritis (RA) that is associated with a significant increase in mortality. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study of 46 patients concludes that pelvic floor training should be included in rehabilitation programs to improve sexual function and pelvic floor dysfunctions for patients with pSS. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This systematic review and meta-analysis aims to comprehensively investigate the immunogenicity of these vaccines in patients with autoimmune inflammatory rheumatoid diseases (AIRDs). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This review aimed to collate and synthesize the current evidence of environmental factors associated with juvenile idiopathic arthritis. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This commentary discusses the Cochrane Review 'Adjunctive therapies in addition to land-based exercise therapy for osteoarthritis of the hip or knee', published by the Cochrane Musculoskeletal Group. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study evaluates predictors for successful biologic tapering among patients with inflammatory arthritis (IA) using baseline characteristics from the BIODOPT trial. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Although ChatGPT is reliable and useful for patients to obtain information about rheumatic diseases, it should be kept in mind that it may give false and misleading answers. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Our study indicates that gastrointestinal surgeries have limited age- and sex-related effects on psoriasis. These findings provide new insights into the risk of developing psoriasis. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
We estimate the causal effect of body mass index (BMI) on the risk of developing five different rheumatic diseases. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Our results suggest there is an advantage in using ePROM monitoring in patients with IA, with potential for reduction in healthcare resource use without detrimental impact in disease outcomes. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This guideline provides initial ACR recommendations on integrative interventions for the management of rheumatoid arthritis to accompany disease-modifying antirheumatic drug treatments. The broad range of interventions included in these recommendations illustrates the importance of an interprofessional, team-based approach to RA management. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Conclusions
Although ChatGPT is reliable and useful for patients to obtain information about rheumatic diseases, it should be kept in mind that it may give false and misleading answers.
To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
We assessed the efficacy of CZP in patients with early and established RA across baseline RF levels. CZP treatment may be considered in patients with RA irrespective of baseline RF levels and time from diagnosis. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Brepocitinib 30 and 60 mg QD were superior to placebo at reducing signs and symptoms of PsA. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This ancillary study of the MAINRITSAN 2 trial aimed to explore the relationship between rituximab plasma concentration, genetic polymorphisms in PK/PD candidate genes, and clinical outcomes. These results suggest that drug monitoring could be useful to individualize the schedule of rituximab administration within the maintenance phase. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Our study indicates a high prevalence of RLS in patients with rheumatic diseases. Early detection and treatment of RLS in patients with rheumatic conditions could be beneficial in improving their overall health and quality of life. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study aims to explore the association between physical capacity tests explored in the consultation and the level of disability in women with fibromyalgia. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Exercise training is crucial for managing ankylosing spondylitis. We evaluated the effects of exercise with different levels of supervision on clinical outcomes in patients with ankylosing spondylitis. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This systematic review aimed to investigate the correlates of sedentary behaviour in people with fibromyalgia using the socio-ecological model. This systematic review aimed to investigate the correlates of SB in PwF using the socio-ecological model.
In this review, we discuss autophagic imbalance in RA and the regulatory mechanisms of circRNAs. We also explore possible targets for circRNA regulation of autophagy in RA. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
We reviewed the impact of key SDH on SLE presentation, management and outcomes, including income, education, neighbourhood factors, healthcare access, discrimination and social support. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
We aimed to assess attitudes and factors affecting the decision-making vis-à-vis COVID-19 vaccination among patients with autoimmune rheumatic diseases (ARDs). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
To compare pain intensity among individuals with idiopathic inflammatory myopathies (IIMs), other systemic autoimmune rheumatic diseases (AIRDs), and without rheumatic disease (wAIDs). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
For patients with connective tissue disease-associated interstitial lung disease (CTD-ILD), early medical intervention would be desirable. This study analyzed the real-world, single-center use of nintedanib for CTD-ILD patients. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.