This exploratory analysis sought to determine whether decreases in cannabis use are associated with improvements in cannabis-related problems and functional outcomes, and if so, what percentage decrease is associated with improvement. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
...This study applied a multidimensional framework to investigate the latent genetic structure underlying heterogeneous dimensions of AUBs. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The introduction of the first antipsychotic drug, chlorpromazine, was a milestone for psychiatry. The authors review the history, classification, indications, mechanism, efficacy, side effects, dosing, drug initiation, switching, and other practical issues and questions related to antipsychotics. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Antipsychotic effectiveness in preventing relapse declines around menopausal age in women with schizophrenia or schizoaffective disorder (SSD). It is not known whether systemic menopausal hormone therapy (MHT) can help to prevent psychosis relapse. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The authors used longitudinal biobank data with up to 25 years of follow-up on over 2,600 clozapine users to derive reliable estimates of the real-world burden of clozapine adverse drug events (ADEs). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Valproic acid (VPA) is used for epilepsy and bipolar disorder. It has near-complete bioavailability and is primarily metabolized by glucuronosyltransferases and mitochondrial oxidation. This case highlights a 79-year-old male with bipolar disorder on VPA therapy that started with flucloxacillin for Staphylococcus aureus bacteraemia and exhibited significantly reduced VPA serum levels. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study aimed to investigate the association between use of proton pump inhibitors (PPI) and frailty index (FI), and to assess the causality relationship using Mendelian randomization (MR). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
In many countries, pain is the most common indication for use of antidepressants in older adults. We reviewed the evidence from randomized controlled trials on the efficacy and safety of antidepressants, compared to all alternatives for pain in older adults (aged ≥65 years). Open access article - no login required
In this paper, we have explored the literature to identify prescribing errors with co-drug products and found several idiosyncrasies that have caused drug errors in the past. Open access article - no login required
We assessed the ability of ChatGPT (generative artificial intelligence-based large language model) to predict DDIs in a real-world setting... Low sensitivity values suggest a lack of success in identifying DDIs by ChatGPT, and further development is required before it can reliably assess potential DDIs in real-world scenarios. Open access article - no login required
Less than 50% of patients treated for hypertension reach a target office systolic blood pressure (SBP). We aimed to evaluate the role of adiposity on antihypertensive drug responses in newly diagnosed hypertensive patients. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study aimed to establish a population pharmacokinetic model for long-term HCQ treatment in patients with rheumatic diseases and to identify the factors influencing HCQ metabolism. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Spinal muscular atrophy (SMA) is a rare inherited autosomal recessive progressive disease of a varying phenotype, with varying clinical symptoms, and as a result the patients suffering from it require multiple types of care. It was deemed useful to conduct a systematic literature review on the pharmacoeconomic evaluations of all currently registered disease-modifying therapies in order to inform policy and highlight research gaps. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study aims to assess the correlation between the second metacarpal cortical index (2MCI) and bone mineral density (BMD) in rheumatoid arthritis patients, and to evaluate machine learning models utilizing 2MCI and clinical parameters for predicting osteoporosis/osteopenia presence and BMD. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study looks at the barriers and facilitators experienced by social prescribing service providers when designing and delivering social prescribing services to support adult mental health. Open access article - no login required.
In this study, interviews were conducted with nurses from a single Hospital at Home site to understand their experiences of providing acute treatments in the context of patients’ homes; and how self-management and social network support roles are perceived. Open access article - no login required.
Research in a local Trust providing health visiting services aimed to describe and interpret the interaction between UK parents and health visitors around infant weight (0–2) in delivering the UK Healthy Child Programme. Open access article - no login required.
This study aimed to investigate the clinical characteristics, seizure recurrence, and epilepsy development in patients with alcohol-related seizures and to identify prognostic factors for epilepsy. Open access article - no login required.
This exploratory analysis assessed relationships between mHealth technology use frequency and alcohol-use outcomes. Using mHealth technologies to moderate drinking without direct prompting or per-use incentives was related to less overall alcohol use and heavy drinking. Open access article - no login required.