The authors performed a target trial emulation to compare the risk of mania among individuals with bipolar depression treated or not treated with antidepressants over a 1-year period. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The primary objective of this study was to evaluate the impact of the IL-6 inhibitor olokizumab on the pharmacokinetics of CYP probe substrates in subjects with active RA. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
To develop a non-linear mixed-effects population pharmacokinetic and pharmacodynamic (PK-PD) model describing the change in the concentration of methotrexate polyglutamates in erythrocytes (ery-MTX-PGn with “n” number of glutamate, representing PK component) and how this relates to modified 28-joint Disease Activity Score incorporating erythrocyte sedimentation rate (DAS-28-3) for rheumatoid arthritis (RA), representing PD component. Open access article - no login required
The aims of this study were to develop a population pharmacokinetic (PK) model for risperidone ISM® and to investigate the relationships between active moiety exposure, as described by apparent clearance (CL40), and several covariates using all data from five clinical studies. Open access article - no login required
This study investigated the safety and effects on regional cerebral blood flow (rCBF) of the oral, brain-penetrant β2-AR agonist, clenbuterol, in healthy volunteers (HV) and patients with mild cognitive impairment (MCI) or Parkinson's disease (PD). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Phosphodiesterase 2 (PDE2) regulates intracellular cyclic adenosine monophosphate and guanosine monophosphate (cAMP/cGMP) levels, which contribute to processes crucial for learning and memory. BI 474121, a potent and selective PDE2 inhibitor, is in development for treating cognitive impairment associated with schizophrenia. Open access article - no login required
Transgender persons face a greater burden of HIV compared to cisgender counterparts. Concerns around drug–drug interactions (DDIs) have been cited as reasons for lower engagement in HIV care and lower pre-exposure prophylaxis (PrEP) uptake among transgender populations. It is therefore imperative for hormone therapy, PrEP and antiretroviral therapy providers to understand the DDI potential between these therapies. Open access article - no login required
This study compared three artificial intelligence (AI) platforms' potential to identify drug therapy communication competencies expected of a graduating medical doctor. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
In this review, we delineate the literature establishing strong support for remote delivery of prolonged exposure (PE) and cognitive processing therapy (CPT); there is also promising support for written exposure therapy (WET) and trauma-focused cognitive behavioral therapy (TF-CBT). We also mention adjunctive and integrative modifications to better serve patients with PTSD. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This conceptual review describes the concept of a personalized model of therapy that leverages a case formulation approach to implementing an evidence-based treatment for PTSD. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
We conducted a systematic review to provide a comprehensive overview of the empirical research on the bidirectional temporal associations between prolonged grief symptoms and symptoms of depression, posttraumatic stress, and anxiety. Open access article - no login required
Despite the widespread use and perceived efficacy of cannabidiol (CBD) as an anxiolytic, few controlled studies have evaluated the effects of CBD on anxiety-relevant indications, and only one has done so in the context of trauma-related symptoms. The current study was designed to address this gap in the literature. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Clinical practice guidelines for the treatment of PTSD/SUD are discussed, along with evidence-based psychotherapies and emerging interventions. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
We sought to determine prevalence rates of high risk for psychosis in UK primary care mental health services and clinical outcomes following routinely delivered psychological therapies. Open access article - no login required
The current study aims to examine the efficacy of CBT delivered via videoconferencing (VCBT) for GAD using a randomized controlled trial design comparing an immediate treatment group to a waitlist control. Open access article - no login required
Participants completed a structured clinical interview for DSM-5, as well as measures of inferential confusion (Dysfunctional Reasoning Processes Task), obsessive beliefs, feared self, OCD symptoms, and psychological distress. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
...little is known about the experience of intrusive cognitions in adolescents, particularly in adolescents with major depressive disorder (MDD) and post-traumatic stress disorder (PTSD). The present study sought to gather fundamental data on these phenomena (i.e., frequency, characteristics and appraisals of intrusive cognitions) in adolescents with MDD and PTSD. Open access article - no login required
We aimed to explore the utility of NEET status (not in education, employment or training) at FEP onset in predicting high threshold clinical remission (absence of positive symptoms and off antipsychotic medication for 6 months) at 3 years following treatment with an early intervention for psychosis service. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study examines psychological, social and environmental risk and protective factors that may explain changes in depression and anxiety among adolescents. Open access article - no login required
The significant clinical heterogeneity among CHR-P individuals suggests that interventions may need to be personalized during this emerging illness phase. We examined longitudinal trajectories within-persons during treatment to investigate whether baseline factors predict symptomatic and functional outcomes. Open access article - no login required
The purpose of this case report is to report the clinical experience of the use of gabapentin in the management of problem behaviors in a person with autism spectrum disorder and comorbid intellectual disability. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Functional impairments contribute to poor quality of life in schizophrenia spectrum disorders (SSD). We sought to (Objective I) define the main functional phenotypes in SSD, then (Objective II) identify key biopsychosocial correlates, emphasizing interpretable data-driven methods. Open access article - no login required
The extraction of linguistic markers from social media posts, which are indicative of the onset and course of mental disorders, offers great potential for mental healthcare. In the present study, we extracted over one million posts from the popular social media platform... Open access article - no login required
We aimed to investigate the potential immune-mediated hyperactivity of KP in individuals with first-episode psychosis (FEP) and the relationship with symptom severity and treatment response outcomes. Open access article - no login required
In this study, we employed a bidirectional two-sample Mendelian randomization framework, leveraging genome-wide association study data from the UK Biobank (n = 85,670) and FinnGen (n = 377,277). Open access article - no login required
Movement of the body is an essential way to characterise autism, according to diagnostic criteria. However, qualifying descriptions of what autistic movements are, their functions and personal value, are missing from academic literature and clinical guidance. We systematically searched for autistic adults’ descriptions of their body and its movement within autobiographical narratives in blog data. Open access article - no login required
Play is often included in autism diagnostic assessments. These tend to focus on ‘deficits’ and non-autistic interpretation of observable behaviours. In contrast, a neurodiversity-affirmative assessment approach involves centring autistic perspectives and focusing on strengths, differences and needs. Accordingly, this study was designed to focus on autistic perspectives of diagnostic assessments that incorporate play. Open access article - no login required
This study aimed to investigate if a 6-month SIT or a continuous aerobic programme could enhance physical performance and cardiac autonomic modulation at rest, during physical activity (PA) and after it in older adults with an ID. Open access article - no login required
People with learning disabilities face distinct challenges as they age. We know that people with a learning disability are at risk of developing the same age-related conditions as the general population but diagnostic overshadowing is still a big problem... To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
To learn about the principles of behaviour change theories and how they can be used to promote physical activity in people with learning disabilities. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
When people with learning disabilities show behaviour that challenges, nurses should try to understand why it is happening and explore ways to divert from it
When people with learning disabilities and/or autism display behaviour that challenges it can be difficult for carers to provide the support the person needs – and it is also damaging to the individual’s quality of life. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This article supports these healthcare professionals to improve the quality of life of service users and those around them by understanding neurodivergence better and developing appropriate strategies for responding to distressed behaviour. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study found strong socioeconomic gradients in 24-hour movement behaviours, with notable differences between weekdays/weekends and behaviour type/posture. These findings emphasise the need to consider socioeconomic position, behaviour type/posture and the day of the week when researching or designing interventions targeting working-age adults. Open access article - no login required.
"We are refreshing our reminiscence collection, looking to create resources from more recent decades, e.g. focusing more on 1970s-90s." This was a suggestion from the OT students we hosted.
This study aims to uncover why maggot therapy is not used more often, particularly in the context of antimicrobial resistance infections, and to determine what can be done to ensure MT is more effectively used in the future to improve patient outcomes and manage the growing problem of AMR. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This item provides evidence-based recommendations regarding the treatment of interstitial lung disease in adults with systemic autoimmune rheumatic diseases. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This item provides evidence-based recommendations regarding screening for interstitial lung disease (ILD) and the monitoring for ILD progression in people with systemic autoimmune rheumatic diseases (SARDs), specifically rheumatoid arthritis, systemic sclerosis, idiopathic inflammatory myopathies, mixed connective tissue disease, and Sjögren disease. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This item concludes that the delivery of health services for children and young people with neurodisability should encompass the broad needs of the family as well as meeting the clinical needs of the CYP. Open access article - no login required.
This article explores the experiences of Black newly qualified social workers and student social workers in England. The research reveals a dire situation in which Black social workers are hindered by racial stereotyping, discrimination, and invisibility. Black social worker voices also highlight suggestions for best practice and guidance for the social work sector about how to improve. Open access article - no login required.
Description of a game where nursing students work in groups to come up with a question that they can challenge the librarian to answer (and explain how to search at the same time).
This paper aims to explore the trends in academic research on elder abuse from 1990 to 2023 using bibliometric analysis. It seeks to identify research trends, hotspots and gaps and proposes future research directions. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study investigates the overall and sex-specific relationship between presence and severity of knee osteoarthritis with muscle composition, power, and energetics in older adults. Open access article - no login required.
This study investigates the experiences of 18 caregivers of people with dementia in Black Caribbean, Black African, and South Asian (Indian, Pakistani, and Bangladeshi) communities in England. Open access article - no login required.
This study found a potential causal association between educational attainment and rheumatoid arthritis, systemic lupus erythematosus, emphasizing the need for further investigation and potential integration of educational attainment into clinical practice to enhance treatment strategies. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The aim of this study was to explore the contribution of cognitions and metacognitive beliefs to trauma symptoms and investigate what predicts symptom burden in traumatized patients. Open access article - no login required.
This paper explores the impact that early-stage dementia has on everyday activities from the perspective of people living with dementia, their supporters and occupational therapy practitioners. Open access article - no login required.
This study assesses whether English local governments’ strategies for place-based health and equity help explain why some disadvantaged areas have better mortality trends than others. Open access article - no login required.
This systematic review examines the effectiveness of community-based multidisciplinary integrated care strategies with general practitioner (GP) participation for community-dwelling older adults and describes the level of care integration in each study. Open access article - no login required.