%0 Conference Paper %1 lanza:2000:ICSB %A Lanza, Guido %A Mydlowec, William %A Koza, John R. %B First International Conference on Systems Biology (ICSB) %C Tokyo %D 2000 %K Biology, algorithms, engineering, genetic lac networks, operon programming, reverse %T Automatic creation of a genetic network for the lac operon from observed data by means of genetic programming %U http://www.genetic-programming.com/jkpdf/icsb2000geneticnetwork.pdf %X This paper demonstrates that it is possible to use genetic programming to automatically create (reverse engineer) a computer program representing the logic underlying the genetic network for the expression level of the lac operon (composed of the Z, Y, and A genes) as measured by its mRNA. Genetic programming starts with observed time-domain expression levels of two genes (REPRESSOR or CAP) and the concentrations of two substances (GLUCOSE or LACTOSE) and automatically creates both a topological arrangement of conditional and comparative functions as well as all necessary numerical parameters of a genetic network whose behavior matches observed time-domain data.

@inproceedings{lanza:2000:ICSB, abstract = {This paper demonstrates that it is possible to use genetic programming to automatically create (reverse engineer) a computer program representing the logic underlying the genetic network for the expression level of the lac operon (composed of the Z, Y, and A genes) as measured by its mRNA. Genetic programming starts with observed time-domain expression levels of two genes (REPRESSOR or CAP) and the concentrations of two substances (GLUCOSE or LACTOSE) and automatically creates both a topological arrangement of conditional and comparative functions as well as all necessary numerical parameters of a genetic network whose behavior matches observed time-domain data.}, added-at = {2008-06-19T17:35:00.000+0200}, address = {Tokyo}, author = {Lanza, Guido and Mydlowec, William and Koza, John R.}, biburl = {https://www.bibsonomy.org/bibtex/265f68a2034c69897870d13f23555b08b/brazovayeye}, booktitle = {First International Conference on Systems Biology (ICSB)}, interhash = {4c26a230acfe9da1eab6839a974b16e2}, intrahash = {65f68a2034c69897870d13f23555b08b}, keywords = {Biology, algorithms, engineering, genetic lac networks, operon programming, reverse}, month = {14-16 November}, notes = {ICSB-2000 8 Feb 2001 ghostview and our printers barf at icsb2000gn.ps population size 10,000}, organisation = {Japan Society for Bioinformatics}, timestamp = {2008-06-19T17:45:09.000+0200}, title = {Automatic creation of a genetic network for the lac operon from observed data by means of genetic programming}, url = {http://www.genetic-programming.com/jkpdf/icsb2000geneticnetwork.pdf}, year = 2000 }