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GPCR and G proteins: drug efficacy and activation in live cells

, , , , , , , и . Mol Endocrinol, 23 (5): 590-9 (мая 2009)Vilardaga, Jean-Pierre Bunemann, Moritz Feinstein, Timothy N Lambert, Nevin Nikolaev, Viacheslav O Engelhardt, Stefan Lohse, Martin J Hoffmann, Carsten Research Support, Non-U.S. Gov't Review United States Molecular endocrinology (Baltimore, Md.) Mol Endocrinol. 2009 May;23(5):590-9. Epub 2009 Feb 5..

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Florian Engelhardt

Börsenprospekthaftung der Leitungsorgane von Emittenten in Deutschland und Schweden. TU Dresden, (2007)

S Hüttelmaier

S Leopold

S Steinlechner

S Ulrich

 

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Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol, , , , , и . J Clin Invest, 117 (1): 229-35 (января 2007)Rochais, Francesca Vilardaga, Jean-Pierre Nikolaev, Viacheslav O Bunemann, Moritz Lohse, Martin J Engelhardt, Stefan Research Support, Non-U.S. Gov't United States The Journal of clinical investigation J Clin Invest. 2007 Jan;117(1):229-35..Altered calcium handling is critically involved in the cardiotoxic effects of chronic beta-adrenergic stimulation, , , , , и . Circulation, 109 (9): 1154-60 (марта 2004)Engelhardt, Stefan Hein, Lutz Dyachenkow, Vitaly Kranias, Evangelia G Isenberg, Gerrit Lohse, Martin J HL26057/HL/NHLBI NIH HHS/United States HL52318/HL/NHLBI NIH HHS/United States HL64018/HL/NHLBI NIH HHS/United States Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. United States Circulation Circulation. 2004 Mar 9;109(9):1154-60. Epub 2004 Feb 16..Self-limitation of intravenous tocolysis with beta2-adrenergic agonists is mediated through receptor G protein uncoupling, , , , , , и . J Clin Endocrinol Metab, 90 (5): 2882-7 (мая 2005)Frambach, Torsten Muller, Thomas Freund, Sebastian Engelhardt, Stefan Sutterlin, Marc Lohse, Martin J Dietl, Johannes Research Support, Non-U.S. Gov't United States The Journal of clinical endocrinology and metabolism J Clin Endocrinol Metab. 2005 May;90(5):2882-7. Epub 2005 Feb 22..Early impairment of calcium handling and altered expression of junctin in hearts of mice overexpressing the beta1-adrenergic receptor, , , , , и . FASEB J, 15 (14): 2718-20 (декабря 2001)Engelhardt, S Boknik, P Keller, U Neumann, J Lohse, M J Hein, L United States The FASEB journal : official publication of the Federation of American Societies for Experimental Biology FASEB J. 2001 Dec;15(14):2718-20. Epub 2001 Oct 15..Inhibition of Na(+)-H(+) exchange prevents hypertrophy, fibrosis, and heart failure in beta(1)-adrenergic receptor transgenic mice, , , , и . Circ Res, 90 (7): 814-9 (апреля 2002)Engelhardt, Stefan Hein, Lutz Keller, Ursula Klambt, Kerstin Lohse, Martin J Research Support, Non-U.S. Gov't United States Circulation research Circ Res. 2002 Apr 19;90(7):814-9..Gs activation is time-limiting in initiating receptor-mediated signaling, , , , , , , , и . J Biol Chem, 281 (44): 33345-51 (ноября 2006)Hein, Peter Rochais, Francesca Hoffmann, Carsten Dorsch, Sandra Nikolaev, Viacheslav O Engelhardt, Stefan Berlot, Catherine H Lohse, Martin J Bunemann, Moritz Research Support, Non-U.S. Gov't United States The Journal of biological chemistry J Biol Chem. 2006 Nov 3;281(44):33345-51. Epub 2006 Sep 8..What is the role of beta-adrenergic signaling in heart failure?, , и . Circ Res, 93 (10): 896-906 (ноября 2003)Lohse, Martin J Engelhardt, Stefan Eschenhagen, Thomas Review United States Circulation research Circ Res. 2003 Nov 14;93(10):896-906..Analysis of beta-adrenergic receptor mRNA levels in human ventricular biopsy specimens by quantitative polymerase chain reactions: progressive reduction of beta 1-adrenergic receptor mRNA in heart failure, , , и . J Am Coll Cardiol, 27 (1): 146-54 (января 1996)Engelhardt, S Bohm, M Erdmann, E Lohse, M J Research Support, Non-U.S. Gov't United states Journal of the American College of Cardiology J Am Coll Cardiol. 1996 Jan;27(1):146-54..Vascular hypertrophy and increased P70S6 kinase in mice lacking the angiotensin II AT(2) receptor, , , , , , , , , и . Circulation, 104 (21): 2602-7 (ноября 2001)Brede, M Hadamek, K Meinel, L Wiesmann, F Peters, J Engelhardt, S Simm, A Haase, A Lohse, M J Hein, L In Vitro Research Support, Non-U.S. Gov't United States Circulation Circulation. 2001 Nov 20;104(21):2602-7..Constitutive activity of the human beta(1)-adrenergic receptor in beta(1)-receptor transgenic mice, , , и . Mol Pharmacol, 60 (4): 712-7 (октября 2001)Engelhardt, S Grimmer, Y Fan, G H Lohse, M J Research Support, Non-U.S. Gov't United States Molecular pharmacology Mol Pharmacol. 2001 Oct;60(4):712-7..