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Correlating drug--target kinetics and in vivo pharmacodynamics: long residence time inhibitors of the FabI enoyl-ACP reductase

, , , , , , , , , , and . Chemical science, 7 (9): 5945--5954 (2016)

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Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors, , , , , , , , , and 6 other author(s). Journal of the American Chemical Society, 139 (9): 3417-3429 (2017)PMID: 28151657.Slow-Onset Inhibition of the FabI Enoyl Reductase from Francisella tularensis: Residence Time and in Vivo Activity, , , , , , , , , and 3 other author(s). ACS Chemical Biology, 4 (3): 221-231 (2009)Structural basis of assembly chaperone-mediated snRNP formation, , , , , , , , and . Molecular cell, 49 (4): 692--703 (2013)A Slow, Tight Binding Inhibitor of InhA, the Enoyl-Acyl Carrier Protein Reductase from Mycobacterium tuberculosis, , , , and . Journal of Biological Chemistry, 285 (19): 14330-14337 (2010)Correlating drug--target kinetics and in vivo pharmacodynamics: long residence time inhibitors of the FabI enoyl-ACP reductase, , , , , , , , , and 1 other author(s). Chemical science, 7 (9): 5945--5954 (2016)Elucidation of the Protonation States of the Catalytic Residues inmtKasA: Implications for Inhibitor Design, , , , and . Biochemistry, 50 (25): 5743--5756 (June 2011)DNA Binding Cooperativity of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis, , , , , , , , , and 3 other author(s). MOLECULAR CELL, 38 (3): 356-368 (May 2010)Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the Staphylococcus aureus FabI Enzyme–Product Complex, , , , , , , , , and . Biochemistry, 52 (24): 4217-4228 (2013)PMID: 23697754.Molecular dynamics of Mycobacterium tuberculosis KasA: implications for inhibitor and substrate binding and consequences for drug design., , and . J. Comput. Aided Mol. Des., 25 (11): 1053-1069 (2011)Crystallizing the 6S and 8S spliceosomal assembly intermediates: a complex project, , , , , , , and . Acta Crystallographica Section D: Biological Crystallography, 71 (10): 2040--2053 (2015)