M. > Adenosine Drug

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1Use of cerebrolysin and ATP in treating infantile cerebral paralysis
R. Gershman, and M. Vasilenko. Pediatr Akus Ginekol, (1975)
10 years ago by @ar0berts
show all tags
Evaluation;
Child;
Humans;
Cerebral
Male;
Combination;
Acids;
Triphosphate;
Preschool;
Child,
Brain;
Tissue
Extracts
Infant;
Palsy;
Female;
Amino
Therapy,
Adenosine
Drug
Evaluation;Child;Humans;CerebralMale;Combination;Acids;Triphosphate;Preschool;Child,Brain;TissueExtractsInfant;Palsy;Female;AminoTherapy,AdenosineDrug
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1Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites
L. Michielan, C. Bolcato, S. Federico, B. Cacciari, M. Bacilieri, K. Klotz, S. Kachler, G. Pastorin, R. Cardin, A. Sperduti and 2 other author(s). Bioorg Med Chem, 17 (14): 5259-74 (July 2009)Michielan, Lisa Bolcato, Chiara Federico, Stephanie Cacciari, Barbara Bacilieri, Magdalena Klotz, Karl-Norbert Kachler, Sonja Pastorin, Giorgia Cardin, Riccardo Sperduti, Alessandro Spalluto, Giampiero Moro, Stefano Research Support, Non-U.S. Gov't England Bioorganic & medicinal chemistry Bioorg Med Chem. 2009 Jul 15;17(14):5259-74. Epub 2009 May 21..
14 years ago by @pharmawuerz
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Binding
&
Sites
A3/*antagonists
Pyrazoles/chemical
Protein
Chemical
Receptor
A2A/*antagonists
inhibitors/chemistry/*metabolism
Discovery
Relationship
Models,
Structure-Activity
Adenosine
Static
Intelligence
Humans
Triazoles/chemical
Electricity
Pyrimidines/chemical
synthesis/*chemistry/*pharmacology
synthesis/chemistry/pharmacology
*Artificial
Drug
Binding&SitesA3/*antagonistsPyrazoles/chemicalProteinChemicalReceptorA2A/*antagonistsinhibitors/chemistry/*metabolismDiscoveryRelationshipModels,Structure-ActivityAdenosineStaticIntelligenceHumansTriazoles/chemicalElectricityPyrimidines/chemicalsynthesis/*chemistry/*pharmacologysynthesis/chemistry/pharmacology*ArtificialDrug
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1The application of a 3D-QSAR (autoMEP/PLS) approach as an efficient pharmacodynamic-driven filtering method for small-sized virtual library: application to a lead optimization of a human A3 adenosine receptor antagonist
S. Moro, M. Bacilieri, B. Cacciari, C. Bolcato, C. Cusan, G. Pastorin, K. Klotz, and G. Spalluto. Bioorg Med Chem, 14 (14): 4923-32 (July 2006)Moro, Stefano Bacilieri, Magdalena Cacciari, Barbara Bolcato, Chiara Cusan, Claudia Pastorin, Giorgia Klotz, Karl-Norbert Spalluto, Giampiero In Vitro Research Support, Non-U.S. Gov't England Bioorganic & medicinal chemistry Bioorg Med Chem. 2006 Jul 15;14(14):4923-32. Epub 2006 Mar 29..
14 years ago by @pharmawuerz
show all tags
Binding
Techniques
&
Sites
A3/*antagonists
Protein
Analysis
Receptor
User-Computer
Chemistry
Relationship
Models,
Structure-Activity
Adenosine
inhibitors/chemistry
Conformation
Static
Interface
Least-Squares
Humans
Molecular
Design
Electricity
Combinatorial
Pyrimidines/chemical
synthesis/chemistry/pharmacology
Quantitative
Drug
BindingTechniques&SitesA3/*antagonistsProteinAnalysisReceptorUser-ComputerChemistryRelationshipModels,Structure-ActivityAdenosineinhibitors/chemistryConformationStaticInterfaceLeast-SquaresHumansMolecularDesignElectricityCombinatorialPyrimidines/chemicalsynthesis/chemistry/pharmacologyQuantitativeDrug
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1Agonist-induced internalization and recycling of the human A(3) adenosine receptors: role in receptor desensitization and resensitization
M. Trincavelli, D. Tuscano, P. Cecchetti, A. Falleni, L. Benzi, K. Klotz, V. Gremigni, F. Cattabeni, A. Lucacchini, and C. Martini. J Neurochem, 75 (4): 1493-501 (October 2000)Trincavelli, M L Tuscano, D Cecchetti, P Falleni, A Benzi, L Klotz, K N Gremigni, V Cattabeni, F Lucacchini, A Martini, C Research Support, Non-U.S. Gov't United states Journal of neurochemistry J Neurochem. 2000 Oct;75(4):1493-501..
14 years ago by @pharmawuerz
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Hydrogen-Ion
Adenosine/*analogs
Cricetinae
&
Radioligand
Concentration
Transduction/drug
Concanavalin
Potassium/metabolism
Membrane/metabolism
effects
Animals
effects/genetics
Receptor
Labels/pharmacokinetics
Endocytosis/drug
Affinity
P1/*agonists/genetics/*metabolism
effects/*physiology
Ligands
Competitive/drug
Adenosine
Temperature
Binding,
Humans
Immunohistochemistry
CHO
Purinergic
Radioisotopes/analysis
Solutions/pharmacology
A/pharmacology
Transfection
Assay
A3
derivatives/pharmacokinetics
Dose-Response
Hypertonic
Relationship,
Iodine
Signal
Cell
Drug
Hydrogen-IonAdenosine/*analogsCricetinae&RadioligandConcentrationTransduction/drugConcanavalinPotassium/metabolismMembrane/metabolismeffectsAnimalseffects/geneticsReceptorLabels/pharmacokineticsEndocytosis/drugAffinityP1/*agonists/genetics/*metabolismeffects/*physiologyLigandsCompetitive/drugAdenosineTemperatureBinding,HumansImmunohistochemistryCHOPurinergicRadioisotopes/analysisSolutions/pharmacologyA/pharmacologyTransfectionAssayA3derivatives/pharmacokineticsDose-ResponseHypertonicRelationship,IodineSignalCellDrug
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1Regulation of p42/p44 mitogen-activated protein kinase by the human adenosine A3 receptor in transfected CHO cells
S. Graham, P. Combes, M. Crumiere, K. Klotz, and J. Dickenson. Eur J Pharmacol, 420 (1): 19-26 (May 2001)Graham, S Combes, P Crumiere, M Klotz, K N Dickenson, J M Research Support, Non-U.S. Gov't Netherlands European journal of pharmacology Eur J Pharmacol. 2001 May 18;420(1):19-26..
14 years ago by @pharmawuerz
show all tags
Adenosine/*analogs
Cricetinae
effects/genetics/metabolism
&
Forskolin/pharmacology
inhibitors/*metabolism
Phosphorylation/drug
derivatives/pharmacology
Protein
1/antagonists
effects
1-Phosphatidylinositol
Animals
inhibitors/metabolism
Receptor
Cyclic
Kinase
Morpholines/pharmacology
Inhibitors/pharmacology
Luciferases/drug
P1/genetics/*physiology
Activation/drug
Fusion
Adenosine
AMP/metabolism
Mitogen-Activated
Chromones/pharmacology
Humans
CHO
Purinergic
Flavonoids/pharmacology
A3
3-Kinase/antagonists
Dose-Response
Proteins/drug
Androstadienes/pharmacology
Relationship,
Enzyme
Recombinant
Cell
Drug
Adenosine/*analogsCricetinaeeffects/genetics/metabolism&Forskolin/pharmacologyinhibitors/*metabolismPhosphorylation/drugderivatives/pharmacologyProtein1/antagonistseffects1-PhosphatidylinositolAnimalsinhibitors/metabolismReceptorCyclicKinaseMorpholines/pharmacologyInhibitors/pharmacologyLuciferases/drugP1/genetics/*physiologyActivation/drugFusionAdenosineAMP/metabolismMitogen-ActivatedChromones/pharmacologyHumansCHOPurinergicFlavonoids/pharmacologyA33-Kinase/antagonistsDose-ResponseProteins/drugAndrostadienes/pharmacologyRelationship,EnzymeRecombinantCellDrug
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1Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor
R. Volpini, M. Buccioni, D. Ben, C. Lambertucci, C. Lammi, G. Marucci, A. Ramadori, K. Klotz, and G. Cristalli. J Med Chem, 52 (23): 7897-900 (December 2009)Volpini, Rosaria Buccioni, Michela Dal Ben, Diego Lambertucci, Catia Lammi, Carmen Marucci, Gabriella Ramadori, Anna T Klotz, Karl-Norbert Cristalli, Gloria Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2009 Dec 10;52(23):7897-900..
14 years ago by @pharmawuerz
show all tags
derivatives/*chemical
Cricetinae
Cricetulus
&
Humans
Adenosine/analogs
A3/*agonists
CHO
Fluorometry
synthesis/*pharmacology
Substrate
Animals
Receptor
Dose-Response
Specificity
Relationship,
Adenosine
Cell
Drug
derivatives/*chemicalCricetinaeCricetulus&HumansAdenosine/analogsA3/*agonistsCHOFluorometrysynthesis/*pharmacologySubstrateAnimalsReceptorDose-ResponseSpecificityRelationship,AdenosineCellDrug
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12-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching
E. Novellino, B. Cosimelli, M. Ehlardo, G. Greco, M. Iadanza, A. Lavecchia, M. Rimoli, A. Sala, A. Settimo, G. Primofiore and 7 other author(s). J Med Chem, 48 (26): 8253-60 (December 2005)Novellino, Ettore Cosimelli, Barbara Ehlardo, Marina Greco, Giovanni Iadanza, Manuela Lavecchia, Antonio Rimoli, Maria Grazia Sala, Annalisa Da Settimo, Antonio Primofiore, Giampaolo Da Settimo, Federico Taliani, Sabrina La Motta, Concettina Klotz, Karl-Norbert Tuscano, Daniela Trincavelli, Maria Letizia Martini, Claudia Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2005 Dec 29;48(26):8253-60..
14 years ago by @pharmawuerz
show all tags
Cricetinae
&
A3/*antagonists
Factual
Competitive
Animals
Receptor
Benzimidazoles/*chemical
A1/*antagonists
Adenosine
Xanthines/metabolism
synthesis/chemistry
Binding,
Humans
Quinoxalines/*chemical
Adenosine/analogs
Adenosine-5'-(N-ethylcarboxamide)/metabolism
CHO
derivatives/metabolism
Design
inhibitors/chemistry/metabolism
A2A/metabolism
*Databases,
Cell
Drug
Cricetinae&A3/*antagonistsFactualCompetitiveAnimalsReceptorBenzimidazoles/*chemicalA1/*antagonistsAdenosineXanthines/metabolismsynthesis/chemistryBinding,HumansQuinoxalines/*chemicalAdenosine/analogsAdenosine-5'-(N-ethylcarboxamide)/metabolismCHOderivatives/metabolismDesigninhibitors/chemistry/metabolismA2A/metabolism*Databases,CellDrug
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1Cardiomyocytes from postinfarction failing rat hearts have improved ischemia tolerance.
M. Sharikabad, J. Aronsen, E. Haugen, J. Pedersen, A. M�ller, H. M�rk, H. Aass, O. Sejersted, I. Sjaastad, and O. Br�rs. Am J Physiol Heart Circ Physiol, 296 (3): H787--H795 (March 2009)
16 years ago by @hake
show all tags
Infarction,
Calcium,
Piperazines,
Failure,
metabolism;
Cultured;
drug
etiology/metabolism/prevention
Sodium
Animals;
Animal;
Factors
Oxygen,
Hypoxia;
Disease
Male;
control;
Time
Cells,
Reperfusion
Rats;
Cell
Death;
L-Lactate
Channel
Radioisotopes;
complications/metabolism/pathology;
Sodium-Calcium
Rats,
effects/enzymology/metabolism/pathology;
Sodium,
pharmacology;
ATPase,
/&/
Acetanilides,
etiology/metabolism/pathology;
Models,
Dehydrogenase,
Exchanger,
Adenosine
Heart
Wistar;
Myocytes,
Blockers,
Rubidium
Potassium,
Triphosphate,
Cardiac,
Myocardial
Sodium-Potassium-Exchanging
Injury,
Infarction,Calcium,Piperazines,Failure,metabolism;Cultured;drugetiology/metabolism/preventionSodiumAnimals;Animal;FactorsOxygen,Hypoxia;DiseaseMale;control;TimeCells,ReperfusionRats;CellDeath;L-LactateChannelRadioisotopes;complications/metabolism/pathology;Sodium-CalciumRats,effects/enzymology/metabolism/pathology;Sodium,pharmacology;ATPase,/&/Acetanilides,etiology/metabolism/pathology;Models,Dehydrogenase,Exchanger,AdenosineHeartWistar;Myocytes,Blockers,RubidiumPotassium,Triphosphate,Cardiac,MyocardialSodium-Potassium-ExchangingInjury,
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1Phosphorylation-dependent regulation of cardiac Na$^+$/Ca$^2+$ exchanger via protein kinase C.
T. Iwamoto, Y. Pan, S. Wakabayashi, T. Imagawa, H. Yamanaka, and M. Shigekawa. J. Biol. Chem., 271 (23): 13609--13615 (June 1996)
16 years ago by @hake
show all tags
Expression;
Calcium,
effects;
Ion
Chickens;
Sequence;
Sequence
Sodium-Calcium
metabolism;
Base
Protein
Transport,
drug
Dogs;
Sodium,
Kinase
pharmacology;
Animals;
DNA
genetics;
Fusion
Adenosine
Tetradecanoylphorbol
genetics/immunology/metabolism;
Acid
Antibodies;
Myocardium,
Line;
C,
Exchanger;
Primers,
Transfection
Triphosphate,
Molecular
Proteins,
Carrier
Phosphorylation;
Acetate,
Gene
Amino
enzymology/metabolism;
Data;
Recombinant
Rats;
Cell
Expression;Calcium,effects;IonChickens;Sequence;SequenceSodium-Calciummetabolism;BaseProteinTransport,drugDogs;Sodium,Kinasepharmacology;Animals;DNAgenetics;FusionAdenosineTetradecanoylphorbolgenetics/immunology/metabolism;AcidAntibodies;Myocardium,Line;C,Exchanger;Primers,TransfectionTriphosphate,MolecularProteins,CarrierPhosphorylation;Acetate,GeneAminoenzymology/metabolism;Data;RecombinantRats;Cell
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publications (hide)9
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1Use of cerebrolysin and ATP in treating infantile cerebral paralysis

1Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites

1The application of a 3D-QSAR (autoMEP/PLS) approach as an efficient pharmacodynamic-driven filtering method for small-sized virtual library: application to a lead optimization of a human A3 adenosine receptor antagonist

1Agonist-induced internalization and recycling of the human A(3) adenosine receptors: role in receptor desensitization and resensitization

1Regulation of p42/p44 mitogen-activated protein kinase by the human adenosine A3 receptor in transfected CHO cells

1Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor

12-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching

1Cardiomyocytes from postinfarction failing rat hearts have improved ischemia tolerance.

1Phosphorylation-dependent regulation of cardiac Na$^+$/Ca$^2+$ exchanger via protein kinase C.

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publications (hide)9 displayallpublications onlypublications per page5102050100 sort byadded attitleauthorpublication dateentry typehelp for advanced sorting... RSSBibTeXRDFmore...

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publications (hide)9
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