Abstract
The primary method for the computational study of biomolecular diffusional
association is Brownian dynamics. Recent work has seen advances in
the efficiency of computing association rates and in the accuracy
of simulation models. New areas to which Brownian dynamics has been
applied include protein polymerisation and protein adsorption to
a surface. There has recently been particularly intense study of
protein-protein association, and Brownian dynamics, together with
other theoretical and experimental approaches, has led to new insights
into the determinants of protein-protein binding kinetics.
- 11959498
- actins,
- antigen-antibody
- biological,
- complex,
- computer
- enzymes,
- gov't,
- kinetics,
- models,
- molecular,
- non-u.s.
- p.h.s.,
- proteins,
- research
- simulation,
- support,
- u.s.
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