%0 Journal Article %1 durrett_limic_01 %A Durrett, Richard %A Limic, Vlada %D 2001 %J Stochastic Processes and their Applications %K SNP branching_processes human_genome %N 1 %P 1--24 %T On the quantity and quality of single nucleotide polymorphisms in the human genome %U http://www.sciencedirect.com/science/article/B6V1B-42NRCTD-1/1/3b00b6dacccc8b20ec0193ee05ccb5e4 %V 93 %X Single nucleotide polymorphisms (SNPs) are useful markers for locating genes since they occur throughout the human genome and thousands can be scored at once using DNA microarrays. Here, we use branching processes and coalescent theory to show that if one uses Kruglyak's (Nature Gen. 12 (1999) 139-144) model of the growth of the human population and one assumes an average mutation rate of 1�10-8 per nucleotide per generation then there are about 5.7 million SNP's in the human genome, or one every 526 base pairs. We also obtain results for the number of SNPs that will be found in samples of sizes ngreater-or-equal, slanted2 to gain insight into the number that will be found by various experimental procedures.

@article{durrett_limic_01, abstract = {Single nucleotide polymorphisms (SNPs) are useful markers for locating genes since they occur throughout the human genome and thousands can be scored at once using DNA microarrays. Here, we use branching processes and coalescent theory to show that if one uses Kruglyak's (Nature Gen. 12 (1999) 139-144) model of the growth of the human population and one assumes an average mutation rate of 1�10-8 per nucleotide per generation then there are about 5.7 million SNP's in the human genome, or one every 526 base pairs. We also obtain results for the number of SNPs that will be found in samples of sizes n[greater-or-equal, slanted]2 to gain insight into the number that will be found by various experimental procedures.}, added-at = {2008-07-22T18:59:02.000+0200}, author = {Durrett, Richard and Limic, Vlada}, biburl = {https://www.bibsonomy.org/bibtex/226e7ffd3c70f47d141c2a36946cec073/peter.ralph}, description = {ScienceDirect - Stochastic Processes and their Applications : On the quantity and quality of single nucleotide polymorphisms in the human genome}, interhash = {68aaacb95a002dba5535025c04db9fde}, intrahash = {26e7ffd3c70f47d141c2a36946cec073}, journal = {Stochastic Processes and their Applications}, keywords = {SNP branching_processes human_genome}, month = {#may#}, number = 1, pages = {1--24}, timestamp = {2008-07-22T18:59:28.000+0200}, title = {On the quantity and quality of single nucleotide polymorphisms in the human genome}, url = {http://www.sciencedirect.com/science/article/B6V1B-42NRCTD-1/1/3b00b6dacccc8b20ec0193ee05ccb5e4}, volume = 93, year = 2001 }