%0 Journal Article %1 braskie2010plaque %A Braskie, Meredith N. %A Klunder, Andrea D. %A Hayashi, Kiralee M. %A Protas, Hillary %A Kepe, Vladimir %A Miller, Karen J. %A Huang, S.-C. %A Barrio, Jorge R. %A Ercoli, Linda M. %A Siddarth, Prabha %A Satyamurthy, Nagichettiar %A Liu, Jie %A Toga, Arthur W. %A Bookheimer, Susan Y. %A Small, Gary W. %A Thompson, Paul M. %D 2010 %J Neurobiology of Aging %K aging alzheimers imaging plaque %N 10 %P 1669 - 1678 %R 10.1016/j.neurobiolaging.2008.09.012 %T Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease %U http://www.sciencedirect.com/science/article/pii/S0197458008003473 %V 31 %X Amyloid plaques and tau neurofibrillary tangles, the pathological hallmarks of Alzheimer's disease (AD), begin accumulating in the healthy human brain decades before clinical dementia symptoms can be detected. There is great interest in how this pathology spreads in the living brain and its association with cognitive deterioration. Using MRI-derived cortical surface models and four-dimensional animation techniques, we related cognitive ability to positron emission tomography (PET) signal from 2-(1-6-(2-F-18fluoroethyl)(methyl)amino-2-naphthylethylidene)malononitrile (18FFDDNP), a molecular imaging probe for plaques and tangles. We examined this relationship at each cortical surface point in 23 older adults (10 cognitively intact, 6 with amnestic mild cognitive impairment, 7 with AD). 18FFDDNP-PET signal was highly correlated with cognitive performance, even in cognitively intact subjects. Animations of 18FFDDNP signal growth with decreased cognition across all subjects (http://www.loni.ucla.edu/∼thompson/FDDNP/video.html) mirrored the classic Braak and Braak trajectory in lateral temporal, parietal, and frontal cortices. Regions in which cognitive performance was significantly correlated with 18FFDDNP signal include those that deteriorate earliest in AD, suggesting the potential utility of 18FFDDNP for early diagnosis.

@article{braskie2010plaque, abstract = {Amyloid plaques and tau neurofibrillary tangles, the pathological hallmarks of Alzheimer's disease (AD), begin accumulating in the healthy human brain decades before clinical dementia symptoms can be detected. There is great interest in how this pathology spreads in the living brain and its association with cognitive deterioration. Using MRI-derived cortical surface models and four-dimensional animation techniques, we related cognitive ability to positron emission tomography (PET) signal from 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile ([18F]FDDNP), a molecular imaging probe for plaques and tangles. We examined this relationship at each cortical surface point in 23 older adults (10 cognitively intact, 6 with amnestic mild cognitive impairment, 7 with AD). [18F]FDDNP-PET signal was highly correlated with cognitive performance, even in cognitively intact subjects. Animations of [18F]FDDNP signal growth with decreased cognition across all subjects (http://www.loni.ucla.edu/∼thompson/FDDNP/video.html) mirrored the classic Braak and Braak trajectory in lateral temporal, parietal, and frontal cortices. Regions in which cognitive performance was significantly correlated with [18F]FDDNP signal include those that deteriorate earliest in AD, suggesting the potential utility of [18F]FDDNP for early diagnosis. }, added-at = {2013-05-27T16:50:22.000+0200}, author = {Braskie, Meredith N. and Klunder, Andrea D. and Hayashi, Kiralee M. and Protas, Hillary and Kepe, Vladimir and Miller, Karen J. and Huang, S.-C. and Barrio, Jorge R. and Ercoli, Linda M. and Siddarth, Prabha and Satyamurthy, Nagichettiar and Liu, Jie and Toga, Arthur W. and Bookheimer, Susan Y. and Small, Gary W. and Thompson, Paul M.}, biburl = {https://www.bibsonomy.org/bibtex/2a1776443c2925332381026ce8376a4cb/benimnetz}, doi = {10.1016/j.neurobiolaging.2008.09.012}, interhash = {6f95ac5e4026a9dcf305757e88dbb1c4}, intrahash = {a1776443c2925332381026ce8376a4cb}, issn = {0197-4580}, journal = {Neurobiology of Aging }, keywords = {aging alzheimers imaging plaque}, number = 10, pages = {1669 - 1678}, timestamp = {2013-05-27T16:50:22.000+0200}, title = {Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease }, url = {http://www.sciencedirect.com/science/article/pii/S0197458008003473}, volume = 31, year = 2010 }