Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations indicate that some cases of athetoid/dystonic or hemiplegic cerebral palsy might arise by fresh dominant genetic mutation.
%0 Journal Article
%1 Fletcher1993
%A Fletcher, N. A.
%A Foley, J.
%D 1993
%J J Med Genet
%K Adolescent; Adult; Athetosis; Birth Order; Cerebral Palsy; Dystonia; Genes, Dominant; Hemiplegia; Humans; Infant, Newborn; Maternal Age; Middle Aged; Mutation; Paralysis; Paternal Quadriplegia
%N 1
%P 44--46
%T Parental age, genetic mutation, and cerebral palsy.
%V 30
%X Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations indicate that some cases of athetoid/dystonic or hemiplegic cerebral palsy might arise by fresh dominant genetic mutation.
@article{Fletcher1993,
abstract = {Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations indicate that some cases of athetoid/dystonic or hemiplegic cerebral palsy might arise by fresh dominant genetic mutation.},
added-at = {2014-07-19T19:28:29.000+0200},
author = {Fletcher, N. A. and Foley, J.},
biburl = {https://www.bibsonomy.org/bibtex/26f9423d191ba64eeacc35ed00db6f51d/ar0berts},
groups = {public},
interhash = {b0fad679c4204a472a562868c31e291b},
intrahash = {6f9423d191ba64eeacc35ed00db6f51d},
journal = {J Med Genet},
keywords = {Adolescent; Adult; Athetosis; Birth Order; Cerebral Palsy; Dystonia; Genes, Dominant; Hemiplegia; Humans; Infant, Newborn; Maternal Age; Middle Aged; Mutation; Paralysis; Paternal Quadriplegia},
month = Jan,
number = 1,
pages = {44--46},
pmid = {8423607},
timestamp = {2014-07-19T19:28:29.000+0200},
title = {Parental age, genetic mutation, and cerebral palsy.},
username = {ar0berts},
volume = 30,
year = 1993
}