Enhanced dermal and retinal vascular permeability in streptozotocin-induced type 1 diabetes in Wistar rats: blockade with a selective bradykinin B1 receptor antagonist.
The vascular complications associated with type 1 diabetes are to some extent related to the dysfunction of the endothelium leading to an increased vascular permeability and plasma extravasation in the surrounding tissues. The various micro- and macro-vascular complications of diabetes develop over time, leading to nephropathy, retinopathy and neuropathy and cardiomyopathy. In the present study, the effect of a novel selective bradykinin B1 receptor (BKB1-R) antagonist, R-954, was investigated on the changes of vascular permeability in the skin and retina of streptozotocin (STZ)-induced type 1 diabetic rats. Plasma extravasation increased in the skin and retina of STZ-diabetic rats after 1 week and persisted over 4 weeks following STZ injection. Acute treatment with R-954 (2 mg/kg, bolus s.c.) highly reduced the elevated vascular permeability in both 1- and 4-week STZ-diabetic rats. These results showed that the inducible BKB1-R subtype modulates the vascular permeability of the skin and retina of type 1 diabetic rats and suggests that BKB1-R antagonists could have a beneficial role in diabetic neuropathy and retinopathy.
%0 Journal Article
%1 Lawson2005
%A Lawson, Sibi R
%A Gabra, Bichoy H
%A Guérin, Brigitte
%A Neugebauer, Witold
%A Nantel, François
%A Battistini, Bruno
%A Sirois, Pierre
%D 2005
%J Regul Pept
%K drugeffects;DiabetesMellitus chemicallyinduced/metabolism;Male;Rats;Rats bloodsupply/drugeffects;Streptozocin Type1 antagonists/&/inhibitors/metabolism;Retina BradykininB1 Animals;CapillaryPermeability Wistar;Receptor pharmacology drugeffects;Skin
%N 1-3
%P 221--224
%R 10.1016/j.regpep.2004.09.002
%T Enhanced dermal and retinal vascular permeability in streptozotocin-induced type 1 diabetes in Wistar rats: blockade with a selective bradykinin B1 receptor antagonist.
%U http://dx.doi.org/10.1016/j.regpep.2004.09.002
%V 124
%X The vascular complications associated with type 1 diabetes are to some extent related to the dysfunction of the endothelium leading to an increased vascular permeability and plasma extravasation in the surrounding tissues. The various micro- and macro-vascular complications of diabetes develop over time, leading to nephropathy, retinopathy and neuropathy and cardiomyopathy. In the present study, the effect of a novel selective bradykinin B1 receptor (BKB1-R) antagonist, R-954, was investigated on the changes of vascular permeability in the skin and retina of streptozotocin (STZ)-induced type 1 diabetic rats. Plasma extravasation increased in the skin and retina of STZ-diabetic rats after 1 week and persisted over 4 weeks following STZ injection. Acute treatment with R-954 (2 mg/kg, bolus s.c.) highly reduced the elevated vascular permeability in both 1- and 4-week STZ-diabetic rats. These results showed that the inducible BKB1-R subtype modulates the vascular permeability of the skin and retina of type 1 diabetic rats and suggests that BKB1-R antagonists could have a beneficial role in diabetic neuropathy and retinopathy.
@article{Lawson2005,
abstract = {The vascular complications associated with type 1 diabetes are to some extent related to the dysfunction of the endothelium leading to an increased vascular permeability and plasma extravasation in the surrounding tissues. The various micro- and macro-vascular complications of diabetes develop over time, leading to nephropathy, retinopathy and neuropathy and cardiomyopathy. In the present study, the effect of a novel selective bradykinin B1 receptor (BKB1-R) antagonist, R-954, was investigated on the changes of vascular permeability in the skin and retina of streptozotocin (STZ)-induced type 1 diabetic rats. Plasma extravasation increased in the skin and retina of STZ-diabetic rats after 1 week and persisted over 4 weeks following STZ injection. Acute treatment with R-954 (2 mg/kg, bolus s.c.) highly reduced the elevated vascular permeability in both 1- and 4-week STZ-diabetic rats. These results showed that the inducible BKB1-R subtype modulates the vascular permeability of the skin and retina of type 1 diabetic rats and suggests that BKB1-R antagonists could have a beneficial role in diabetic neuropathy and retinopathy.},
added-at = {2011-08-01T20:07:51.000+0200},
author = {Lawson, Sibi R and Gabra, Bichoy H and Guérin, Brigitte and Neugebauer, Witold and Nantel, François and Battistini, Bruno and Sirois, Pierre},
biburl = {https://www.bibsonomy.org/bibtex/2210ba6593244184adc4e11098efe7e8c/crc_chus},
doi = {10.1016/j.regpep.2004.09.002},
institution = {Institute of Pharmacology of Sherbrooke, School of Medicine, University of Sherbrooke, Sherbrooke, PQ, J1H 5N4, Canada.},
interhash = {1c479bacb288a26a529261752eed323b},
intrahash = {210ba6593244184adc4e11098efe7e8c},
journal = {Regul Pept},
keywords = {drugeffects;DiabetesMellitus chemicallyinduced/metabolism;Male;Rats;Rats bloodsupply/drugeffects;Streptozocin Type1 antagonists/&/inhibitors/metabolism;Retina BradykininB1 Animals;CapillaryPermeability Wistar;Receptor pharmacology drugeffects;Skin},
language = {eng},
medline-pst = {ppublish},
month = Jan,
number = {1-3},
pages = {221--224},
pii = {S0167-0115(04)00351-9},
pmid = {15544863},
timestamp = {2011-08-01T20:07:51.000+0200},
title = {Enhanced dermal and retinal vascular permeability in streptozotocin-induced type 1 diabetes in Wistar rats: blockade with a selective bradykinin B1 receptor antagonist.},
url = {http://dx.doi.org/10.1016/j.regpep.2004.09.002},
volume = 124,
year = 2005
}