%0 Journal Article %1 pmid14634638 %A Biola, Oduola. %A Angel, Joe. M. %A Avner, Philip. %A Bachmanov, Alexander. A. %A Belknap, John. K. %A Bennett, Beth. %A th. P. Blankenhorn, Elizabe %A Blizard, David. A. %A Bolivar, Valerie. %A Brockmann, Gundrun. A. %A Buck, Kari. J. %A Bureau, Jean.-Francoise %A Casley, William. L. %A ler, Elissa. J. Ches %A Cheverud, James. M. %A Churchill, Gary. A. %A ni. Cook, Mello %A Crabbe, John. C. %A Crusio, Wim. E. %A Darvasi, Ariel. %A de Haan., Gerald. %A Dermant, Peter. %A Doerge, R. W. %A Elliot, Rosemary. W. %A er, Charles. R. Farb %A Flaherty, Lorraine. %A Flint, Jonathan. %A oward. Gershenfeld, H %A Gibson, John. P. %A Gu, Jing. %A Gu, Weikuan. %A nz. Himmelbauer, Hei %A Hitzemann, Robert. %A Hsu, Hui.-Chen %A Hunter, Kent. %A Iraqi, Fuad . F. %A Jansen, Ritsert. C. %A Johnson, Thomas. E. %A Jones, Byron. C. %A empermann, Gerd. K %A Lammert, Frank. %A Lu, Lu. %A Manly, Kenneth. F. %A thews, Douglas. B. Mat %A Medrano, Juan. F. %A Mehrabian, Margarete. %A nn, Guy. Mittlema %A Mock, Beverly. A. %A Mogil, Jeffrey. S. %A Montagutelli, Xavier. %A Morahan, Grant. %A Mountz, John. D. %A Nagase, Hiroki. %A ichard. S. Nowakowski, R %A O'Hara, Bruce. F. %A Osadchuk, Alexander. V. %A y. Paigen, Beverl %A Palmer, Abraham. A. %A Peirce, Jeremy. L. %A Pomp, Daniel. %A n, Michael. Roseman %A Rosen, Glenn. D. %A Schalkwyk, Leonard. C. %A Seltzer, Ze.'ev %A Settle, Stephen. %A Shimomura, Kazuhiro. %A Shou, Siming. %A mes. M. Sikela, Ja %A Siracusa, Linda. D. %A Spearow, Jimmy. L. %A Teuscher, Cory. %A Threadgill, David. W. %A Toth, Linda. A. %A Toye, Ayo. A. %A Vadasz, Csaba. %A Zant., Gary. Van %A Wakeland, Edward. %A Williams, Robert. W. %A Zhang, Huang.-Ge %A Zou, Fei. %D 2003 %J Nat Rev Genet %K imported %N 11 %P 911-916 %T The nature and identification of quantitative trait loci: a communit y's view %V 4 %X This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL? Much of the genetic variation that underlies disease susceptibility and morphology is complex and is governed by loci that have quantitative effects on the phenotype. Gene�gene and gene�environment interactions are common and make these loci difficult to analyse. Here, we present a community's view on the steps that are necessary to identify genetic loci that govern quantitative traits, along with a set of interpretive guidelines. This community mostly represents interests in the analyses of rodent quantitative trait loci (QTLs), although many of the same principles apply to other species.

@article{pmid14634638, abstract = {This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL? Much of the genetic variation that underlies disease susceptibility and morphology is complex and is governed by loci that have quantitative effects on the phenotype. Gene�gene and gene�environment interactions are common and make these loci difficult to analyse. Here, we present a community's view on the steps that are necessary to identify genetic loci that govern quantitative traits, along with a set of interpretive guidelines. This community mostly represents interests in the analyses of rodent quantitative trait loci (QTLs), although many of the same principles apply to other species.}, added-at = {2007-01-09T17:36:36.000+0100}, author = {Biola, Oduola. and Angel, Joe. M. and Avner, Philip. and Bachmanov, Alexander. A. and Belknap, John. K. and Bennett, Beth. and th. P. Blankenhorn, Elizabe and Blizard, David. A. and Bolivar, Valerie. and Brockmann, Gundrun. A. and Buck, Kari. J. and Bureau, Jean.-Francoise and Casley, William. L. and ler, Elissa. J. Ches and Cheverud, James. M. and Churchill, Gary. A. and ni. Cook, Mello and Crabbe, John. C. and Crusio, Wim. E. and Darvasi, Ariel. and de Haan., Gerald. and Dermant, Peter. and Doerge, R. W. and Elliot, Rosemary. W. and er, Charles. R. Farb and Flaherty, Lorraine. and Flint, Jonathan. and oward. Gershenfeld, H and Gibson, John. P. and Gu, Jing. and Gu, Weikuan. and nz. Himmelbauer, Hei and Hitzemann, Robert. and Hsu, Hui.-Chen and Hunter, Kent. and Iraqi, Fuad . F. and Jansen, Ritsert. C. and Johnson, Thomas. E. and Jones, Byron. C. and empermann, Gerd. K and Lammert, Frank. and Lu, Lu. and Manly, Kenneth. F. and thews, Douglas. B. Mat and Medrano, Juan. F. and Mehrabian, Margarete. and nn, Guy. Mittlema and Mock, Beverly. A. and Mogil, Jeffrey. S. and Montagutelli, Xavier. and Morahan, Grant. and Mountz, John. D. and Nagase, Hiroki. and ichard. S. Nowakowski, R and O'Hara, Bruce. F. and Osadchuk, Alexander. V. and y. Paigen, Beverl and Palmer, Abraham. A. and Peirce, Jeremy. L. and Pomp, Daniel. and n, Michael. Roseman and Rosen, Glenn. D. and Schalkwyk, Leonard. C. and Seltzer, Ze.'ev and Settle, Stephen. and Shimomura, Kazuhiro. and Shou, Siming. and mes. M. Sikela, Ja and Siracusa, Linda. D. and Spearow, Jimmy. L. and Teuscher, Cory. and Threadgill, David. W. and Toth, Linda. A. and Toye, Ayo. A. and Vadasz, Csaba. and Zant., Gary. Van and Wakeland, Edward. and Williams, Robert. W. and Zhang, Huang.-Ge and Zou, Fei.}, biburl = {https://www.bibsonomy.org/bibtex/25219b11448a33000db7242ae7b200f6a/pjotrp}, howpublished = {nrg1206.pdf}, interhash = {d802f57371384bb0286eb679926d9eff}, intrahash = {5219b11448a33000db7242ae7b200f6a}, journal = {Nat Rev Genet}, keywords = {imported}, month = Nov, number = 11, pages = {911-916}, timestamp = {2007-01-09T17:36:36.000+0100}, title = {{The nature and identification of quantitative trait loci: a communit y's view}}, volume = 4, year = 2003 }