Simple approximations to some limiting cases of Ca++ signalling provide
insight into the complex problems of buffered diffusion and of Ca++
homeostasis in the presence of buffers. Three cases are presented,
where the influence of Ca++ buffers can readily be understood in
the limit of small signals: the return of global cellular Ca++
following a short stimulus in a 'Single Compartment', buffered diffusion
along a cylindrical axon in the 'Rapid Buffer Approximation', and
nonequilibrium microdomains of elevated Ca++ in the immediate vicinity
of open Ca++ channels.
%0 Journal Article
%1 Nehe_1998_345
%A Neher, E.
%D 1998
%J Cell Calcium
%K 10091004 Adenosine Animals, Botulinum Calcium Calcium, Cattle, Cells, Chromaffin Diffusion, Drug Exocytosis, Gov't, Kinetics, Linear Membrane Models, Molecular, Nerve Non-U.S. Proteins, Research Resistance, Signaling, Support, Tetanus Tissue Toxin, Toxins, Triphosphate,
%N 5-6
%P 345--357
%T Usefulness and limitations of linear approximations to the understanding
of Ca++ signals.
%V 24
%X Simple approximations to some limiting cases of Ca++ signalling provide
insight into the complex problems of buffered diffusion and of Ca++
homeostasis in the presence of buffers. Three cases are presented,
where the influence of Ca++ buffers can readily be understood in
the limit of small signals: the return of global cellular Ca++
following a short stimulus in a 'Single Compartment', buffered diffusion
along a cylindrical axon in the 'Rapid Buffer Approximation', and
nonequilibrium microdomains of elevated Ca++ in the immediate vicinity
of open Ca++ channels.
@article{Nehe_1998_345,
abstract = {Simple approximations to some limiting cases of Ca++ signalling provide
insight into the complex problems of buffered diffusion and of Ca++
homeostasis in the presence of buffers. Three cases are presented,
where the influence of Ca++ buffers can readily be understood in
the limit of small signals: the return of global cellular [Ca++]
following a short stimulus in a 'Single Compartment', buffered diffusion
along a cylindrical axon in the 'Rapid Buffer Approximation', and
nonequilibrium microdomains of elevated [Ca++] in the immediate vicinity
of open Ca++ channels.},
added-at = {2009-06-03T11:20:58.000+0200},
author = {Neher, E.},
biburl = {https://www.bibsonomy.org/bibtex/2733bc6fce0922c0d52fe175ab42ef803/hake},
description = {The whole bibliography file I use.},
file = {Nehe_1998_345.pdf:Nehe_1998_345.pdf:PDF},
interhash = {5490d90608ae8458927c253618190e6c},
intrahash = {733bc6fce0922c0d52fe175ab42ef803},
journal = {Cell Calcium},
key = 51,
keywords = {10091004 Adenosine Animals, Botulinum Calcium Calcium, Cattle, Cells, Chromaffin Diffusion, Drug Exocytosis, Gov't, Kinetics, Linear Membrane Models, Molecular, Nerve Non-U.S. Proteins, Research Resistance, Signaling, Support, Tetanus Tissue Toxin, Toxins, Triphosphate,},
number = {5-6},
pages = {345--357},
pmid = {10091004},
timestamp = {2009-06-03T11:21:23.000+0200},
title = {Usefulness and limitations of linear approximations to the understanding
of Ca++ signals.},
volume = 24,
year = 1998
}