%0 Journal Article %1 Weischenfeldt2013 %A Weischenfeldt, Joachim %A Simon, Ronald %A Feuerbach, Lars %A Schlangen, Karin %A Weichenhan, Dieter %A Minner, Sarah %A Wuttig, Daniela %A Warnatz, Hans-Jörg %A Stehr, Henning %A Rausch, Tobias %A Jäger, Natalie %A Gu, Lei %A Bogatyrova, Olga %A Stütz, Adrian M. %A Claus, Rainer %A Eils, Jürgen %A Eils, Roland %A Gerhäuser, Clarissa %A Huang, Po-Hsien %A Hutter, Barbara %A Kabbe, Rolf %A Lawerenz, Christian %A Radomski, Sylwester %A Bartholomae, Cynthia C. %A Fälth, Maria %A Gade, Stephan %A Schmidt, Manfred %A Amschler, Nina %A Haß, Thomas %A Galal, Rami %A Gjoni, Jovisa %A Kuner, Ruprecht %A Baer, Constance %A Masser, Sawinee %A von Kalle, Christof %A Zichner, Thomas %A Benes, Vladimir %A Raeder, Benjamin %A Mader, Malte %A Amstislavskiy, Vyacheslav %A Avci, Meryem %A Lehrach, Hans %A Parkhomchuk, Dmitri %A Sultan, Marc %A Burkhardt, Lia %A Graefen, Markus %A Huland, Hartwig %A Kluth, Martina %A Krohn, Antje %A Sirma, Hüseyin %A Stumm, Laura %A Steurer, Stefan %A Grupp, Katharina %A Sültmann, Holger %A Sauter, Guido %A Plass, Christoph %A Brors, Benedikt %A Yaspo, Marie-Laure %A Korbel, Jan O. %A Schlomm, Thorsten %D 2013 %J Cancer Cell %K 80 Adult; Aged, Aged; Androgen, Biology; Computational Endopeptidases, Fusion, Gene Genomics; High-Throughput Humans; Male; Middle Neoplasms, Nucleotide Oncogene Prostatic Proteins, Rearrangement; Receptors, Sequencing; Serine Trans-Activators, and genetics genetics; over; %N 2 %P 159--170 %R 10.1016/j.ccr.2013.01.002 %T Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer. %U http://dx.doi.org/10.1016/j.ccr.2013.01.002 %V 23 %X Early-onset prostate cancer (EO-PCA) represents the earliest clinical manifestation of prostate cancer. To compare the genomic alteration landscapes of EO-PCA with "classical" (elderly-onset) PCA, we performed deep sequencing-based genomics analyses in 11 tumors diagnosed at young age, and pursued comparative assessments with seven elderly-onset PCA genomes. Remarkable age-related differences in structural rearrangement (SR) formation became evident, suggesting distinct disease pathomechanisms. Whereas EO-PCAs harbored a prevalence of balanced SRs, with a specific abundance of androgen-regulated ETS gene fusions including TMPRSS2:ERG, elderly-onset PCAs displayed primarily non-androgen-associated SRs. Data from a validation cohort of > 10,000 patients showed age-dependent androgen receptor levels and a prevalence of SRs affecting androgen-regulated genes, further substantiating the activity of a characteristic ändrogen-type" pathomechanism in EO-PCA.

@article{Weischenfeldt2013, __markedentry = {[bbrors:6]}, abstract = {Early-onset prostate cancer (EO-PCA) represents the earliest clinical manifestation of prostate cancer. To compare the genomic alteration landscapes of EO-PCA with "classical" (elderly-onset) PCA, we performed deep sequencing-based genomics analyses in 11 tumors diagnosed at young age, and pursued comparative assessments with seven elderly-onset PCA genomes. Remarkable age-related differences in structural rearrangement (SR) formation became evident, suggesting distinct disease pathomechanisms. Whereas EO-PCAs harbored a prevalence of balanced SRs, with a specific abundance of androgen-regulated ETS gene fusions including TMPRSS2:ERG, elderly-onset PCAs displayed primarily non-androgen-associated SRs. Data from a validation cohort of > 10,000 patients showed age-dependent androgen receptor levels and a prevalence of SRs affecting androgen-regulated genes, further substantiating the activity of a characteristic "androgen-type" pathomechanism in EO-PCA.}, added-at = {2015-04-09T12:36:21.000+0200}, author = {Weischenfeldt, Joachim and Simon, Ronald and Feuerbach, Lars and Schlangen, Karin and Weichenhan, Dieter and Minner, Sarah and Wuttig, Daniela and Warnatz, Hans-J{\"{o}}rg and Stehr, Henning and Rausch, Tobias and J{\"{a}}ger, Natalie and Gu, Lei and Bogatyrova, Olga and St{\"{u}}tz, Adrian M. and Claus, Rainer and Eils, J{\"{u}}rgen and Eils, Roland and Gerh{\"{a}}user, Clarissa and Huang, Po-Hsien and Hutter, Barbara and Kabbe, Rolf and Lawerenz, Christian and Radomski, Sylwester and Bartholomae, Cynthia C. and F{\"{a}}lth, Maria and Gade, Stephan and Schmidt, Manfred and Amschler, Nina and Ha{\ss}, Thomas and Galal, Rami and Gjoni, Jovisa and Kuner, Ruprecht and Baer, Constance and Masser, Sawinee and {von Kalle}, Christof and Zichner, Thomas and Benes, Vladimir and Raeder, Benjamin and Mader, Malte and Amstislavskiy, Vyacheslav and Avci, Meryem and Lehrach, Hans and Parkhomchuk, Dmitri and Sultan, Marc and Burkhardt, Lia and Graefen, Markus and Huland, Hartwig and Kluth, Martina and Krohn, Antje and Sirma, H{\"{u}}seyin and Stumm, Laura and Steurer, Stefan and Grupp, Katharina and S{\"{u}}ltmann, Holger and Sauter, Guido and Plass, Christoph and Brors, Benedikt and Yaspo, Marie-Laure and Korbel, Jan O. and Schlomm, Thorsten}, biburl = {https://www.bibsonomy.org/bibtex/275c2f570b1fcf3426e3aa9c78d9acee9/bbrors}, doi = {10.1016/j.ccr.2013.01.002}, institution = {Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, 69117 Heidelberg, Germany.}, interhash = {311e7e512228dd9b0c458d9c427680c7}, intrahash = {75c2f570b1fcf3426e3aa9c78d9acee9}, journal = {Cancer Cell}, keywords = {80 Adult; Aged, Aged; Androgen, Biology; Computational Endopeptidases, Fusion, Gene Genomics; High-Throughput Humans; Male; Middle Neoplasms, Nucleotide Oncogene Prostatic Proteins, Rearrangement; Receptors, Sequencing; Serine Trans-Activators, and genetics genetics; over;}, language = {eng}, medline-pst = {ppublish}, month = Feb, number = 2, owner = {bbrors}, pages = {159--170}, pii = {S1535-6108(13)00004-4}, pmid = {23410972}, timestamp = {2015-04-09T12:36:21.000+0200}, title = {Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer.}, url = {http://dx.doi.org/10.1016/j.ccr.2013.01.002}, volume = 23, year = 2013 }