%0 Journal Article %1 Dibble20061280 %A Dibble, Leland E. %A Hale, Tessa %A Marcus, Robin L. %A Gerber, J. Parry %A LaStayo, Paul C. %D 2006 %J Archives of Physical Medicine and Rehabilitation %K Parkinson %N 9 %P 1280-1282 %R http://dx.doi.org/10.1016/j.apmr.2006.05.016 %T The Safety and Feasibility of High-Force Eccentric Resistance Exercise in Persons With Parkinson’s Disease %U http://www.sciencedirect.com/science/article/pii/S0003999306004680 %V 87 %X Dibble LE, Hale T, Marcus RL, Gerber JP, LaStayo PC. The safety and feasibility of high-force eccentric resistance in persons with Parkinson’s disease. Objective To examine the effect of high-force eccentric resistance exercise on measures of muscle damage and injury in persons with mild to moderate Parkinson’s disease (PD). Design Before-after trial. Setting Tertiary care center clinical laboratory. Participants Ten persons with \PD\ (Hoehn and Yahr Staging Scale, stage 1–3). Intervention Participants trained 3 days a week for 12 weeks on an eccentric ergometer, performing high-force eccentric resistance exercise with bilateral lower extremities. Main Outcome Measures Serum creatine kinase (CK) concentrations, muscle pain scores, and isometric force production were measured before, during, and after training. Results Mean \CK\ levels did not differ and did not exceed the threshold of muscle damage at any time point (P=.17). Muscle visual analog scale scores were low and only differed at week 2 (P=.04). Participants were highly compliant, whereas total negative work and isometric force increased over time (P=.02, P=.006, respectively). Conclusions Persons with mild to moderate \PD\ can safely and feasibly participate in high-force eccentric resistance training. The data we present provide a basis for future investigations of the efficacy of this type of training on muscle size, strength, and mobility in persons with PD.

@article{Dibble20061280, abstract = {Dibble LE, Hale T, Marcus RL, Gerber JP, LaStayo PC. The safety and feasibility of high-force eccentric resistance in persons with Parkinson’s disease. Objective To examine the effect of high-force eccentric resistance exercise on measures of muscle damage and injury in persons with mild to moderate Parkinson’s disease (PD). Design Before-after trial. Setting Tertiary care center clinical laboratory. Participants Ten persons with \{PD\} (Hoehn and Yahr Staging Scale, stage 1–3). Intervention Participants trained 3 days a week for 12 weeks on an eccentric ergometer, performing high-force eccentric resistance exercise with bilateral lower extremities. Main Outcome Measures Serum creatine kinase (CK) concentrations, muscle pain scores, and isometric force production were measured before, during, and after training. Results Mean \{CK\} levels did not differ and did not exceed the threshold of muscle damage at any time point (P=.17). Muscle visual analog scale scores were low and only differed at week 2 (P=.04). Participants were highly compliant, whereas total negative work and isometric force increased over time (P=.02, P=.006, respectively). Conclusions Persons with mild to moderate \{PD\} can safely and feasibly participate in high-force eccentric resistance training. The data we present provide a basis for future investigations of the efficacy of this type of training on muscle size, strength, and mobility in persons with PD. }, added-at = {2015-05-29T11:21:02.000+0200}, author = {Dibble, Leland E. and Hale, Tessa and Marcus, Robin L. and Gerber, J. Parry and LaStayo, Paul C.}, biburl = {https://www.bibsonomy.org/bibtex/27408f7c5c1ea3469698d7cf94f4af1cc/nrzlit}, doi = {http://dx.doi.org/10.1016/j.apmr.2006.05.016}, interhash = {825f8f55709a54cac33ed89990ac1d4e}, intrahash = {7408f7c5c1ea3469698d7cf94f4af1cc}, issn = {0003-9993}, journal = {Archives of Physical Medicine and Rehabilitation }, keywords = {Parkinson}, number = 9, pages = {1280-1282}, timestamp = {2015-05-29T11:21:02.000+0200}, title = {The Safety and Feasibility of High-Force Eccentric Resistance Exercise in Persons With Parkinson’s Disease }, url = {http://www.sciencedirect.com/science/article/pii/S0003999306004680}, volume = 87, year = 2006 }