%0 Journal Article %1 Henderson1995 %A Henderson, R. C. %A Lin, P. P. %A Greene, W. B. %D 1995 %J J Bone Joint Surg Am %K Adolescent; Analysis of Variance; Body Mass Index; Bone Density; Diseases, Metabolic; Calcitriol; Calcium, Dietary; Case-Control Studies; Cerebral Palsy; Child; Child, Preschool; Female; Femur; Humans; Lumbar Vertebrae; Male; Multivariate Analysis; Nutrition Assessment; Disorders; Regression Skinfold Thickness; Statistics, Nonparametric; Walking %N 11 %P 1671--1681 %T Bone-mineral density in children and adolescents who have spastic cerebral palsy. %V 77 %X Bone-mineral density was studied in a heterogeneous group of 139 children (mean age, nine years; range, three to fifteen years) who had spastic cerebral palsy. The evaluation included serum analyses and a nutritional assessment based on a dietary history and anthropometric measurements. The bone-mineral density of the proximal parts of the femora and the lumbar spine was measured with dual-energy x-ray absorptiometry and was normalized for age against a series of ninety-five normal children and adolescents who served as controls. Bone-mineral density varied greatly but averaged nearly one standard deviation below the age-matched normal means for both the proximal parts of the femora (-0.92 standard deviation) and the lumbar spine (-0.80 standard deviation). Ambulatory status was the factor that best correlated with bone-mineral density. Nutritional status, assessed on the basis of caloric intake, skinfolds, and body-mass index, was the second most significant variable. The pattern of involvement, durations of immobilization in a cast, and a calcium intake of less than 500 milligrams per day were additional factors of less significance. The age when the child first walked, previous fractures, use of anticonvulsants, and serum vitamin-D levels did not correlate with bone-mineral density after adjustment for covariance with the ambulatory status and the nutritional status. Serum levels of calcium, phosphate, alkaline phosphatase, and osteocalcin were not reliable indicators of low bone-mineral density.

@article{Henderson1995, abstract = {Bone-mineral density was studied in a heterogeneous group of 139 children (mean age, nine years; range, three to fifteen years) who had spastic cerebral palsy. The evaluation included serum analyses and a nutritional assessment based on a dietary history and anthropometric measurements. The bone-mineral density of the proximal parts of the femora and the lumbar spine was measured with dual-energy x-ray absorptiometry and was normalized for age against a series of ninety-five normal children and adolescents who served as controls. Bone-mineral density varied greatly but averaged nearly one standard deviation below the age-matched normal means for both the proximal parts of the femora (-0.92 standard deviation) and the lumbar spine (-0.80 standard deviation). Ambulatory status was the factor that best correlated with bone-mineral density. Nutritional status, assessed on the basis of caloric intake, skinfolds, and body-mass index, was the second most significant variable. The pattern of involvement, durations of immobilization in a cast, and a calcium intake of less than 500 milligrams per day were additional factors of less significance. The age when the child first walked, previous fractures, use of anticonvulsants, and serum vitamin-D levels did not correlate with bone-mineral density after adjustment for covariance with the ambulatory status and the nutritional status. Serum levels of calcium, phosphate, alkaline phosphatase, and osteocalcin were not reliable indicators of low bone-mineral density.}, added-at = {2014-07-19T20:20:51.000+0200}, author = {Henderson, R. C. and Lin, P. P. and Greene, W. B.}, biburl = {https://www.bibsonomy.org/bibtex/2e5388682f6e0f5233a9eae2ff9c0fa58/ar0berts}, groups = {public}, interhash = {97afbac0885580e9eb434d34ad365138}, intrahash = {e5388682f6e0f5233a9eae2ff9c0fa58}, journal = {J Bone Joint Surg Am}, keywords = {Adolescent; Analysis of Variance; Body Mass Index; Bone Density; Diseases, Metabolic; Calcitriol; Calcium, Dietary; Case-Control Studies; Cerebral Palsy; Child; Child, Preschool; Female; Femur; Humans; Lumbar Vertebrae; Male; Multivariate Analysis; Nutrition Assessment; Disorders; Regression Skinfold Thickness; Statistics, Nonparametric; Walking}, month = Nov, number = 11, pages = {1671--1681}, pmid = {7593076}, timestamp = {2014-07-19T20:20:51.000+0200}, title = {Bone-mineral density in children and adolescents who have spastic cerebral palsy.}, username = {ar0berts}, volume = 77, year = 1995 }