%0 Journal Article %1 Stavoe2019 %A Stavoe, Andrea K H %A Holzbaur, Erika L F %D 2019 %J Annu. Rev. Cell Dev. Biol %K ER aggrephagy autophagy homeostasis mitophagy neuro neurodegeneration phagy %P 477--500 %R 10.1146/annurev-cellbio-100818 %T Cellular Logistics: Unraveling the Interplay Between Microtubule Organization and Intracellular Transport %U https://doi.org/10.1146/annurev-cellbio-100818- %V 35 %X Autophagy is the major cellular pathway to degrade dysfunctional organelles and protein aggregates. Autophagy is particularly important in neurons, which are terminally differentiated cells that must last the lifetime of the organism. There are both constitutive and stress-induced pathways for au-tophagy in neurons, which catalyze the turnover of aged or damaged mito-chondria, endoplasmic reticulum, other cellular organelles, and aggregated proteins. These pathways are required in neurodevelopment as well as in the maintenance of neuronal homeostasis. Here we review the core components of the pathway for autophagosome biogenesis, as well as the cell biology of bulk and selective autophagy in neurons. Finally, we discuss the role of autophagy in neuronal development, homeostasis, and aging and the links between deficits in autophagy and neurodegeneration.

@article{Stavoe2019, abstract = {Autophagy is the major cellular pathway to degrade dysfunctional organelles and protein aggregates. Autophagy is particularly important in neurons, which are terminally differentiated cells that must last the lifetime of the organism. There are both constitutive and stress-induced pathways for au-tophagy in neurons, which catalyze the turnover of aged or damaged mito-chondria, endoplasmic reticulum, other cellular organelles, and aggregated proteins. These pathways are required in neurodevelopment as well as in the maintenance of neuronal homeostasis. Here we review the core components of the pathway for autophagosome biogenesis, as well as the cell biology of bulk and selective autophagy in neurons. Finally, we discuss the role of autophagy in neuronal development, homeostasis, and aging and the links between deficits in autophagy and neurodegeneration.}, added-at = {2020-03-23T21:12:34.000+0100}, author = {Stavoe, Andrea K H and Holzbaur, Erika L F}, biburl = {https://www.bibsonomy.org/bibtex/283b8a2e193e317ff7c85e456a4d2343a/kfriedl}, doi = {10.1146/annurev-cellbio-100818}, file = {:C$\backslash$:/Users/Karoline/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Burute, Kapitein - 2019 - Annual Review of Cell and Developmental Biology Cellular Logistics Unraveling the Interplay Between Microtubul.pdf:pdf}, interhash = {dfc31bfefaf5a98e182d6d233c08597c}, intrahash = {83b8a2e193e317ff7c85e456a4d2343a}, journal = {Annu. Rev. Cell Dev. Biol}, keywords = {ER aggrephagy autophagy homeostasis mitophagy neuro neurodegeneration phagy}, pages = {477--500}, timestamp = {2020-04-07T12:28:47.000+0200}, title = {Cellular Logistics: Unraveling the Interplay Between Microtubule Organization and Intracellular Transport}, url = {https://doi.org/10.1146/annurev-cellbio-100818-}, volume = 35, year = 2019 }