%0 Journal Article %1 Bottcher2006dk %A Böttcher, J %A Pfeil, A %A Rosholm, A %A Sörös, P %A Petrovitch, A %A Schaefer, ML %A Seidl, BE %A Malich, A %A Hansch, A %A Wolf, G %A Kaiser, WA %D 2006 %J Invest Radiol %K Severity and Adolescent Middle Aged, Rheumatoid/pathology Disease Bone Illness Demineralization, Radiographic 80 neuroscience Densitometry, Joint/pathology Arthritis, Non-U.S. Support, Software Aged Adult Index of Gov't Male AND Linear Image X-Ray/*methods Pathologic/pathology Female Models Nonparametric over Research Humans Enhancement/*methods Statistics, Progression Metacarpophalangeal %N 1 %P 36-44 %T Computerized quantification of joint space narrowing and periarticular demineralization in patients with rheumatoid arthritis based on digital x-ray radiogrammetry. %V 41 %X OBJECTIVES: The aim of our work was to evaluate digital x-ray radiogrammetry (DXR) for the quantification of disease-related periarticular demineralization and computerized analysis of joint space distances (JSDA) for the measurement of joint space narrowing as a new diagnostic method for the early detection of joint-associated alterations and for monitoring disease progression in patients with rheumatoid arthritis (RA). MATERIALS AND METHODS: Digital radiographs in 313 patients with varying severity of RA were performed annually and assessed by 2 radiologists using modified Larsen and also the Sharp scores within an observation period of 3 years. The hand radiographs underwent measurements of bone mineral density (BMD) and metacarpal index (MCI) by DXR, as well as computerized JSDA at the metacarpal-phalangeal articulation (JSD-MCP) for a cross-sectional and longitudinal study design. RESULTS: Both DXR-BMD (-29.6%; P < 0.01) and DXR-MCI (-31.0%; P < 0.01) revealed a notable reduction dependent on the severity of RA (from grade 1 to grade 5 of the modified Larsen score); the severity dependent decrease of mean JSD-MCP ranged from -31.9% (P < 0.01; Sharp erosion part) to -39.1% (P < 0.01) for the modified Larsen score. Over an observation period of 3 years, a significant decrease of DXR-BMD (-22.3%) and DXR-MCI (-23.3%) as well as JSD-MCP mean (-17.5%) was observed (P < 0.05), whereas an accentuated decline of DXR and JSDA parameters was verified for patients without disease-modifying antirheumatic drugs or methotrexate therapy. CONCLUSION: Computerized analysis of hand radiographs by DXR and JSDA is a promising approach to assess the severity and to monitor the progression of RA because DXR and JSDA are timely able to measure periarticular demineralization and also narrowing of JSD-MCP dependent on the severity, the medical treatment and the course of RA.

@article{Bottcher2006dk, abstract = {OBJECTIVES: The aim of our work was to evaluate digital x-ray radiogrammetry (DXR) for the quantification of disease-related periarticular demineralization and computerized analysis of joint space distances (JSDA) for the measurement of joint space narrowing as a new diagnostic method for the early detection of joint-associated alterations and for monitoring disease progression in patients with rheumatoid arthritis (RA). MATERIALS AND METHODS: Digital radiographs in 313 patients with varying severity of RA were performed annually and assessed by 2 radiologists using modified Larsen and also the Sharp scores within an observation period of 3 years. The hand radiographs underwent measurements of bone mineral density (BMD) and metacarpal index (MCI) by DXR, as well as computerized JSDA at the metacarpal-phalangeal articulation (JSD-MCP) for a cross-sectional and longitudinal study design. RESULTS: Both DXR-BMD (-29.6%; P < 0.01) and DXR-MCI (-31.0%; P < 0.01) revealed a notable reduction dependent on the severity of RA (from grade 1 to grade 5 of the modified Larsen score); the severity dependent decrease of mean JSD-MCP ranged from -31.9% (P < 0.01; Sharp erosion part) to -39.1% (P < 0.01) for the modified Larsen score. Over an observation period of 3 years, a significant decrease of DXR-BMD (-22.3%) and DXR-MCI (-23.3%) as well as JSD-MCP mean (-17.5%) was observed (P < 0.05), whereas an accentuated decline of DXR and JSDA parameters was verified for patients without disease-modifying antirheumatic drugs or methotrexate therapy. CONCLUSION: Computerized analysis of hand radiographs by DXR and JSDA is a promising approach to assess the severity and to monitor the progression of RA because DXR and JSDA are timely able to measure periarticular demineralization and also narrowing of JSD-MCP dependent on the severity, the medical treatment and the course of RA.}, added-at = {2006-05-30T01:06:19.000+0200}, affiliation = {Institute of Diagnostic and Interventional Radiology; Friedrich-Schiller-University Jena, Germany. joachim.boettcher@med.uni-jena.de}, au = {B{\"o}ttcher, J}, author = {B{\"o}ttcher, J and Pfeil, A and Rosholm, A and S{\"o}r{\"o}s, P and Petrovitch, A and Schaefer, ML and Seidl, BE and Malich, A and Hansch, A and Wolf, G and Kaiser, WA}, biburl = {https://www.bibsonomy.org/bibtex/2f2000f94121d667b4ed4c808556ca645/asterix}, da = {20051215}, date-added = {2006-05-29 18:55:11 -0400}, date-modified = {2006-05-29 18:55:12 -0400}, dcom = {20060323}, description = {neuroscience literature}, edat = {2005/12/16 09:00}, interhash = {e439c1c4371fe7febe6b52e0d0457abc}, intrahash = {f2000f94121d667b4ed4c808556ca645}, issn = {0020-9996}, jid = {0045377}, journal = {Invest Radiol}, keywords = {Severity and Adolescent Middle Aged, Rheumatoid/pathology Disease Bone Illness Demineralization, Radiographic 80 neuroscience Densitometry, Joint/pathology Arthritis, Non-U.S. Support, Software Aged Adult Index of Gov't Male AND Linear Image X-Ray/*methods Pathologic/pathology Female Models Nonparametric over Research Humans Enhancement/*methods Statistics, Progression Metacarpophalangeal}, language = {eng}, mhda = {2006/03/24 09:00}, month = Jan, number = 1, own = {NLM}, pages = {36-44}, pmid = {16355038}, pst = {ppublish}, pt = {Journal Article}, pubm = {Print}, so = {Invest Radiol 2006 Jan;41(1):36-44.}, stat = {MEDLINE}, timestamp = {2006-05-30T01:06:19.000+0200}, title = {Computerized quantification of joint space narrowing and periarticular demineralization in patients with rheumatoid arthritis based on digital x-ray radiogrammetry.}, volume = 41, year = 2006 }