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Molecular basis of partial agonism at the neurotransmitter alpha2A-adrenergic receptor and Gi-protein heterotrimer

, , , , and . J Biol Chem, 281 (34): 24506-11 (August 2006)Nikolaev, Viacheslav O Hoffmann, Carsten Bunemann, Moritz Lohse, Martin J Vilardaga, Jean-Pierre Research Support, Non-U.S. Gov't United States The Journal of biological chemistry J Biol Chem. 2006 Aug 25;281(34):24506-11. Epub 2006 Jun 20..

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Kinetic analysis of G protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells, , , , and . Adv Protein Chem, (2007)Lohse, Martin J Hoffmann, Carsten Nikolaev, Viacheslav O Vilardaga, Jean-Pierre Bunemann, Moritz Research Support, Non-U.S. Gov't Review United States Advances in protein chemistry Adv Protein Chem. 2007;74:167-88..GPCR and G proteins: drug efficacy and activation in live cells, , , , , , , and . Mol Endocrinol, 23 (5): 590-9 (May 2009)Vilardaga, Jean-Pierre Bunemann, Moritz Feinstein, Timothy N Lambert, Nevin Nikolaev, Viacheslav O Engelhardt, Stefan Lohse, Martin J Hoffmann, Carsten Research Support, Non-U.S. Gov't Review United States Molecular endocrinology (Baltimore, Md.) Mol Endocrinol. 2009 May;23(5):590-9. Epub 2009 Feb 5..Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism, , , , and . Proc Natl Acad Sci U S A, 102 (44): 16084-9 (November 2005)Castro, Marian Nikolaev, Viacheslav O Palm, Dieter Lohse, Martin J Vilardaga, Jean-Pierre Research Support, Non-U.S. Gov't United States Proceedings of the National Academy of Sciences of the United States of America Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16084-9. Epub 2005 Oct 18..A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells, , , , , , , , , and . Nat Methods, 2 (3): 171-6 (March 2005)Hoffmann, Carsten Gaietta, Guido Bunemann, Moritz Adams, Stephen R Oberdorff-Maass, Silke Behr, Bjorn Vilardaga, Jean-Pierre Tsien, Roger Y Ellisman, Mark H Lohse, Martin J P41RR004050/RR/NCRR NIH HHS/United States Comparative Study Evaluation Studies Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. United States Nature methods Nat Methods. 2005 Mar;2(3):171-6. Epub 2005 Feb 17..Molecular mechanisms of receptor activation: real-time analysis by fluorescence resonance energy transfer, , and . Auton Autacoid Pharmacol, 23 (4): 231-3 (August 2003)Lohse, Martin J Vilardaga, Jean-Pierre Bunemann, Moritz Lectures England Autonomic & autacoid pharmacology Auton Autacoid Pharmacol. 2003 Aug;23(4):231-3..Fluorescence resonance energy transfer analysis of alpha 2a-adrenergic receptor activation reveals distinct agonist-specific conformational changes, , , , , and . Mol Pharmacol, 75 (3): 534-41 (March 2009)Zurn, A Zabel, U Vilardaga, J-P Schindelin, H Lohse, M J Hoffmann, C Comparative Study Research Support, Non-U.S. Gov't United States Molecular pharmacology Mol Pharmacol. 2009 Mar;75(3):534-41. Epub 2008 Dec 23..Kinetics of G-protein-coupled receptor signals in intact cells, , , , , and . Br J Pharmacol, (March 2008)Lohse, M J Hein, P Hoffmann, C Nikolaev, V O Vilardaga, J-P Bunemann, M Research Support, Non-U.S. Gov't Review England British journal of pharmacology Br J Pharmacol. 2008 Mar;153 Suppl 1:S125-32. Epub 2008 Jan 14..Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors, , , , , and . Trends Pharmacol Sci, 29 (3): 159-65 (March 2008)Lohse, Martin J Nikolaev, Viacheslav O Hein, Peter Hoffmann, Carsten Vilardaga, Jean-Pierre Bunemann, Moritz Review England Trends in pharmacological sciences Trends Pharmacol Sci. 2008 Mar;29(3):159-65. Epub 2008 Feb 11..Direct optical recording of intrinsic efficacy at a G protein-coupled receptor, , and . Life Sci, 74 (2-3): 397-404 (December 2003)Lohse, Martin J Vilardaga, Jean Pierre Bunemann, Moritz Research Support, Non-U.S. Gov't England Life sciences Life Sci. 2003 Dec 5;74(2-3):397-404..Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol, , , , , and . J Clin Invest, 117 (1): 229-35 (January 2007)Rochais, Francesca Vilardaga, Jean-Pierre Nikolaev, Viacheslav O Bunemann, Moritz Lohse, Martin J Engelhardt, Stefan Research Support, Non-U.S. Gov't United States The Journal of clinical investigation J Clin Invest. 2007 Jan;117(1):229-35..