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Precision medicine as a control problem: Using simulation and deep reinforcement learning to discover adaptive, personalized multi-cytokine therapy for sepsis.

, , , , , , and . CoRR, (2018)

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A hybrid simulation model for studying acute inflammatory response., , and . SpringSim (2), page 39-46. SCS/ACM, (2007)Precision medicine as a control problem: Using simulation and deep reinforcement learning to discover adaptive, personalized multi-cytokine therapy for sepsis., , , , , , and . CoRR, (2018)Examining the dynamics of epithelial metaplasia and pouchitis in an ileal pouch with a spatially-explicit computational multi-scale gut model (MSGM)., , , , and . SpringSim (ADS), page 4. SCS/ACM, (2013)Toward mechanistic medical digital twins: some use cases in immunology., , , , , , , , , and 9 other author(s). Frontiers Digit. Health, (2024)SPARK: a framework for multi-scale agent-based biomedical modeling., , , , , , , and . SpringSim, page 3. SCS/ACM, (2010)A proposed method for dynamic knowledge representation via agent-directed composition from biomedical and simulation ontologies: an example using gut mucus layer dynamics., and . SpringSim (ADS), page 37-44. SCS/ACM, (2011)Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome, , , , , , , , , and 2 other author(s). Nature Medicine, 15 (6): 641--648 (June 2009)PMID: 19465927.A proposal for augmenting biological model construction with a semi-intelligent computational modeling assistant., and . Comput. Math. Organ. Theory, 18 (4): 380-403 (2012)Djangology: A Light-weight Web-based Tool for Distributed Collaborative Text Annotation., , , , and . LREC, European Language Resources Association, (2010)A multiscale modeling approach to inflammation: A case study in human endotoxemia., , , , , , , , , and . J. Comput. Phys., (2013)