Ampakines capable of improving cognition by enhancing brain activity under normal circumstances may also have the potential to reduce the harmful or unwanted effects of sleep deprivation. (CX717 by Cortex Pharmaceuticals)
Armodafinil (Nuvigil®) is an eugeroic drug made by Cephalon, FDA-approved 6/15/2007. Clinical trials for its use in bipolar disorder, cognition in schizophrenia, excessive fatigue in Parkinson's & cancer, begin. Patent expires 2023.
Armodafinil From Wikipedia, the free encyclopedia Jump to: navigation, search Armodafinil Systematic (IUPAC) name (-)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide Identifiers CAS number 68693-11-8 ATC code N06BA07 PubChem ? Chemical data Formu
Modafinil induces wakefulness, but its dopamine-releasing action in the nucleus accumbens is weak and dose-dependent; no likelihood of euphoric response ('abuse potential').
For narcolepsy, or off-label for depression, night-shift work, ADHD/ADD...a prodrug, metabolizes to modafinil (Provigil®), resulting in nearly identical pharmacological effects, takes 45-60 minutes to reach active levels in bloodstream.
In patients with depression who experience sedation as a side effect of antidepressants, adjunctive modafinil improved wakefulness & reduced fatigue. Modafinil plus SSRIs improved mood & quality of life.
In patients with depression who experience sedation as a side effect of antidepressants, adjunctive modafinil improved wakefulness & reduced fatigue. Modafinil plus SSRIs improved mood & quality of life.
In 10 to 20 years we'll be able to pharmacologically turn sleep off. It's already being quelled with Modafinil, a stimulant with a near-mythical reputation for keeping you awake without the jitters, excessive euphoria, and eventual crash that come after