Open Journal of Pediatrics (OJPed) is an international journal dedicated to the latest advancement of Pediatrics. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of Pediatrics. All manuscripts must be prepared in English, and are subject to a rigorous and fair peer-review process.
Open Journal of Internal Medicine（OJIM）is an international journal dedicated to the latest advancement of internal medicine. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of internal medicine.
Open Journal of Pediatrics (OJPed) is an international journal dedicated to the latest advancement of Pediatrics. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of Pediatrics. All manuscripts must be prepared in English, and are subject to a rigorous and fair peer-review process. Accepted papers will immediately appear online followed by printed hard copy.
We describe how innate and adaptive immune cascades trigger the release of cytokines and chemokines, resulting in the initiation and progression of atherosclerosis. We discuss how cytokines have direct and indirect effects on myocardial function.
Atherosclerosis is the predominant underlying pathology of cardiovascular disease...atherosclerotic lesions are characterized by abundance of immune cells and their effector molecules, eventually leading to unstable angina, myocardial infarction, or strok
The cellular and extracellular matrix accumulations that comprise the lesions of atherosclerosis are driven by local release of cytokines at sites of predilection for lesion formation, and by the specific attraction and activation of cells expressing rece
Researchers say circulating mononuclear cells (the largest type of white blood cell) and lymphocytes, exist in a proinflammatory state in obese persons known to be at increased risk of developing heart disease, diabetes, or both.
Exposure to secondhand smoke leads to inflammation and oxidation, representing another pathophysiologic mechanism for the development of atherosclerosis.
Statins may act on an enzyme called endothelial nitric oxide synthase, which stimulates nitric oxide production. Increased nitric oxide has anti-inflammatory and anti-clotting effects...
Over 20 large-scale prospective studies show that the inflammatory biomarker high-sensitivity C-reactive protein (hsCRP) is an independent predictor of future cardiovascular events
Researchers said today they have identified the mechanism of action of lipoic acid, a remarkable compound that in animal experiments appears to slow down the process of aging, improve blood flow, enhance immune function and perform many other functions.
Dr. Noboru Ashida, Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaramachi, Shogoin Sakyo-ku, Kyoto 606-8507, Japan. Voice +81-75-751-3465; fax: +81-75-751-3574; ash@kuhp.kyoto.u.ac.jp.
Angiographic pattern of in-stent restenosis (ISR) after drug-eluting stent (DES) implantation different to that after bare metal stent (BMS), but their subsequent TLR rate was similar to both types of DES.
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY. Judith Branger, Bernt van den Blink, Sebastiaan Weijer, Abhya Gupta, Sander J.H. van Deventer, C. Erik Hack, Maikel P. Peppelenbosch, and Tom van der Poll
The anti-inflammatory potential of an oral p38 MAPK inhibitor in humans in vivo suggests that p38 MAPK inhibitors may provide a new therapeutic option in the treatment of inflammatory diseases. Boehringer Ingelheim. 2002 Branger J, et al
Eating walnuts can reverse the impairment of endothelial function associated with eating a fatty meal. But olive oil did not have the same beneficial effect. "When we eat a fatty meal, inflammatory molecules are increased that prevent the endothelium fro
A decrease in the oxidative damage to low-density lipoprotein (LDL) cholesterol is one of the protective mechanisms in which a traditional Mediterranean diet exerts a protective effect on coronary heart disease development.
While the cause of statin-associated myopathy is controversial, a central role for coenzyme Q10 (CoQ10 or ubiquinone) is slowly gaining acceptance. Statins have been shown to create an acquired CoQ10 deficiency.
ntake of Fish Oil, Oleic Acid, Folic Acid, and Vitamins B-6 and E for 1 Year Decreases Plasma C-Reactive Protein and Reduces Coronary Heart Disease Risk Factors in Male Patients in a Cardiac Rehabilitation Program1
Statins exert their pleiotropic effects, in part, by improving endothelial function via up-regulation of endothelial nitric oxide synthase enzyme activity.
B. George, S. Seals, and I. Aban. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 21 (4):
686-94(August 2014)Anàlisi de supervivència; Introductori; SAS.
S. Deb, P. Austin, J. Tu, D. Ko, C. Mazer, A. Kiss, and S. Fremes. The Canadian journal of cardiology, 32 (2):
259-65(February 2016)Propensity score; CV; Introductori<br/><br/>Taula 1 de ATE/ATT per mètode.
S. Pocock, T. Clayton, and G. Stone. Journal of the American College of Cardiology, 66 (25):
2886-98(December 2015)Disseny; Dissenys adaptatius; Tests d'equivalència; Early stopping; RCT; Introductori; CV<br/><br/>Molts exemples i bons gràfics.
S. Pocock, J. McMurray, and T. Collier. Journal of the American College of Cardiology, 66 (23):
2648-62(December 2015)Disseny; RCT; CV; Introductori; Comparacions múltiples; Composite endpoints; Intention to treat; Anàlisi de subgrups.
