The cellular and extracellular matrix accumulations that comprise the lesions of atherosclerosis are driven by local release of cytokines at sites of predilection for lesion formation, and by the specific attraction and activation of cells expressing rece
Exposure to secondhand smoke leads to inflammation and oxidation, representing another pathophysiologic mechanism for the development of atherosclerosis.
Researchers say circulating mononuclear cells (the largest type of white blood cell) and lymphocytes, exist in a proinflammatory state in obese persons known to be at increased risk of developing heart disease, diabetes, or both.
Angiographic pattern of in-stent restenosis (ISR) after drug-eluting stent (DES) implantation different to that after bare metal stent (BMS), but their subsequent TLR rate was similar to both types of DES.
Anti-Inflammatory Effects of Pioglitazone and/or Simvastatin in High Cardiovascular Risk Patients With Elevated High Sensitivity C-Reactive Protein The PIOSTAT Study
While the cause of statin-associated myopathy is controversial, a central role for coenzyme Q10 (CoQ10 or ubiquinone) is slowly gaining acceptance. Statins have been shown to create an acquired CoQ10 deficiency.
Eating walnuts can reverse the impairment of endothelial function associated with eating a fatty meal. But olive oil did not have the same beneficial effect. "When we eat a fatty meal, inflammatory molecules are increased that prevent the endothelium fro
ntake of Fish Oil, Oleic Acid, Folic Acid, and Vitamins B-6 and E for 1 Year Decreases Plasma C-Reactive Protein and Reduces Coronary Heart Disease Risk Factors in Male Patients in a Cardiac Rehabilitation Program1
Drug-eluting stents (DES) have gained widespread adoption being implanted in over 6 million patients worldwide demonstrating significant improvements in clinical efficacy combined with comparable safety to bare metal stents.
Modern cardiology has given up on curing heart disease. Its aggressive interventions-- coronary artery bypass graft, atherectomy, angioplasty, and stenting--do not reduce the frequency of new heart attacks or prolong survival except in small subsets of pa
it may no longer be enough to measure just HDL levels without determining levels of paroxonase and platelet-activating acetylhydrolase; levels of these enzymes may determine whether HDL is proinflammatory or protective. Likewise, measuring Lp(a) and small
For "traditional" cardiologists, CAD is a blockage or blockages in the coronary arteries, and the treatment is stents. For "nontraditional" cardiologists, CAD is a more systemic, diffuse condition, and the treatment is systemic.
Techniques for penetrating chronic total occlusion (CTO) to ensure complete revascularization using percutaneous coronary techniques. Success is only 50–75%, even in the best hands. How to improve?
We must optimize stent deployment & maintain a registry of how well (or poorly) we use drug-eluting stents. Instead of asking “Which stent?” or “How much anti-platelet therapy?” we must ask “How effectively are we deploying our stents?”
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We describe how innate and adaptive immune cascades trigger the release of cytokines and chemokines, resulting in the initiation and progression of atherosclerosis. We discuss how cytokines have direct and indirect effects on myocardial function.
Atherosclerosis is the predominant underlying pathology of cardiovascular disease...atherosclerotic lesions are characterized by abundance of immune cells and their effector molecules, eventually leading to unstable angina, myocardial infarction, or strok
Statins may act on an enzyme called endothelial nitric oxide synthase, which stimulates nitric oxide production. Increased nitric oxide has anti-inflammatory and anti-clotting effects...
Women and Heart Disease The Role of Diabetes and Hyperglycemia Elizabeth Barrett-Connor, MD; Elsa-Grace V. Giardina, MD; Anselm K. Gitt, MD; Uwe Gudat, MD; Helmut O. Steinberg, MD; Diethelm Tschoepe, MD Arch Intern Med. 2004;164:934-942.
S. Deb, P. Austin, J. Tu, D. Ko, C. Mazer, A. Kiss, und S. Fremes. The Canadian journal of cardiology, 32 (2):
259-65(Februar 2016)Propensity score; CV; Introductori<br/><br/>Taula 1 de ATE/ATT per mètode.
B. George, S. Seals, und I. Aban. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 21 (4):
686-94(August 2014)Anàlisi de supervivència; Introductori; SAS.
S. Pocock, T. Clayton, und G. Stone. Journal of the American College of Cardiology, 66 (25):
2886-98(Dezember 2015)Disseny; Dissenys adaptatius; Tests d'equivalència; Early stopping; RCT; Introductori; CV<br/><br/>Molts exemples i bons gràfics.
S. Pocock, J. McMurray, und T. Collier. Journal of the American College of Cardiology, 66 (23):
2648-62(Dezember 2015)Disseny; RCT; CV; Introductori; Comparacions múltiples; Composite endpoints; Intention to treat; Anàlisi de subgrups.