Chronic heavy alcohol use impacts all major neurotransmitter systems and is associated with multiple medical, psychiatric, and social problems. Available evidence-based medications to treat alcohol use disorder (AUD) are underutilized in clinical practice. These medications promote abstinence or reduce alcohol consumption, though there are questions regarding their optimal dosage, length of treatment, and utility in combination with one another. Pharmacogenetic approaches, which use a patient's genetic make-up to inform medication selection, have garnered great interest but have yet to yield results robust enough to incorporate them in routine clinical care. This narrative review summarizes the evidence both for medications approved by the Food and Drug Administration (disulfiram, oral naltrexone, acamprosate, and extended-release naltrexone) and those commonly used off-label (e.g., gabapentin, baclofen, and topiramate) for AUD treatment. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Although clozapine is the most efficacious medication for treatment-refractory schizophrenia, not all patients will have an adequate response. Optimising clozapine dose using therapeutic drug monitoring could therefore maximise response. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
A manager’s skills in responding to a mistake can encourage a culture of safety and openness
Effective leadership can improve reporting, risk identification and safer practice (Lappalainen et al 2020). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The aim of this systematic review and meta-analysis was to evaluate whether use of misoprostol decreases the risk of NSAID-induced kidney injury. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study evaluates predictors for successful biologic tapering among patients with inflammatory arthritis (IA) using baseline characteristics from the BIODOPT trial. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This scoping review aimed to assess the extent and nature of gabapentinoid deprescribing interventions in adults, either in reducing dosages, or prescribing of, gabapentinoids. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
To provide post-hoc analyses of a clinical trial that reported beneficial effects of medication reviews on health-related quality of life. Specifically, to describe the medication changes with a focus on deprescribing, and to explore patient- and medication-related factors that may identify patients most likely to benefit from medication reviews. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Aim: To conduct an overview of systematic reviews examining interventions to stimulate spontaneous reporting of suspected adverse drug reactions (ADRs) by HCPs and/or patients/carers. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The objectives of this work are to a) discuss this rare phenomenon through a series of ten patients and a relevant literature review, b) conceptualise its neurobiological underpinnings, and c) explore the preliminary treatment approaches for its management. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Antiseizure medications (ASMs) are the second most widely prescribed psychotropic for people with intellectual disabilities in England. Multiple psychotropic prescribing is prevalent in almost half of people with intellectual disabilities on ASMs. This analysis identifies limited evidence of ASM benefit in challenging behaviour management and suggests improvements needed to inform clinical practice. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
To minimise infection during COVID-19, the clozapine haematological monitoring interval was extended from 4-weekly to 12-weekly intervals in South London and Maudsley NHS Foundation Trust. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The authors investigated transitions to schizophrenia spectrum or bipolar disorder following different types of substance-induced psychosis and the impact of gender, age, number of emergency admissions related to substance-induced psychosis, and type of substance-induced psychosis on such transitions. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
CYP2C19 is a hepatic enzyme involved in the metabolism of antidepressants associated with increased gastrointestinal bleed (GIB) risk. The aim of our study is to explore a possible association between loss of function CYP2C19 genotypes and GIB in South-Asian ancestry participants prescribed antidepressants. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study aims to explore the views and experiences of pharmacist independent prescribing (IPs) regarding prescribing errors and strategies to mitigate errors in practice. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
In the United Kingdom (UK) anti-seizure medications (ASMs) are the second most widely prescribed psychotropic agent for PwID. However, it is unclear what the current evidence and patterns is on current prescribing of ASMs including when and how a case is made to withdraw them. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
We aimed to systematically synthesize the current published literature on neonatal growth outcomes associated with antiseizure medications (ASMs) use during pregnancy. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This State of the Nation Report looks at product information for medicines, the needs and preferences of patients and healthcare professionals, and how people engage with this information.
Opinion piece. The upcoming workforce plan from NHS England is expected to set out a future where there are not only more health care staff, but also different types of staff, which could encompass new skills or new professions. If it is not simply 'more of the same’, what could this different future look like? We already have one example well in train.
This study aimed to establish a prediction model of quetiapine concentration in patients with schizophrenia and depression, based on real-world data via machine learning techniques to assist clinical regimen decisions. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study utilized physiologically based pharmacokinetic (PBPK) and pharmacodynamic (PD) modeling to further examine the underlying mechanisms of anxiety treatment and addiction. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.