Mitogen-activated protein kinase p38 is a serin/threonine kinase originally isolated from lipopolysaccharide stimulated monocytes. There are 4 isoforms; p38-a activation has been most widely studied for inflammation...
Precise control of thedistribution of specific proteins is essential for many biological processes. An LMU team has now described a new model for intracellular pattern formation. Here, the shape of the cell itself plays a ...
Molecular Biology: Structure and Dynamics of Genomes and Proteomes illustrates the essential principles behind the transmission and expression of genetic information at the level of DNA, RNA, and proteins. This textbook emphasizes the experimental basis of discovery and the most recent advances in the field while presenting a structural, mechanistic understanding of molecular biology that is rigorous, yet concise. The text is written for advanced undergraduate or graduate-level courses in molecular biology.
Mr. Leilidyn Y Zurbano*, Mary Lynn M Mariposque, Lyka M Buenaobra, and Mr. John Christopher Marquez from the institute of the Agribusiness Department, Polytechnic University of the Philippines, Lopez Quezon, Philippines, developed a research work entitled "Growth and protein content of mud crabs (Scylla serrata) fed with different natural feeds," published by the Journal of Biodiversity and Environmental Sciences | JBES, on March issue 2021, Volume 18, under the publication of the International Network For Natural Sciences | INNSPUB.
We apply a simulational proxy of the -value analysis and perform extensive mutagenesis experiments to identify the nucleating residues in the folding “reactions” of two small lattice G polymers with different native geometries. Our findings show that for the more complex native fold (i.e., the one that is rich in nonlocal, long-range bonds), mutation of the residues that form the folding nucleus leads to a considerably larger increase in the folding time than the corresponding mutati...
Dr. Noboru Ashida, Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaramachi, Shogoin Sakyo-ku, Kyoto 606-8507, Japan. Voice +81-75-751-3465; fax: +81-75-751-3574; ash@kuhp.kyoto.u.ac.jp.
The ExPASy (Expert Protein Analysis System) proteomics server of the Swiss Institute of Bioinformatics (SIB) is dedicated to the analysis of protein sequences and structures as well as 2-D PAGE (Disclaimer / References).
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Since 1971, the Protein Data Bank archive (PDB) has served as the single repository of information about the 3D structures of proteins, nucleic acids, and complex assemblies.
The Worldwide PDB (wwPDB) organization manages the PDB archive and ensures that the PDB is freely and publicly available to the global community.
Proteins play countless roles throughout the biological world, from catalyzing chemical reactions to building the structures of all living things. Despite this wide range of functions all proteins are made out of the same twenty amino acids, but combined in different ways. The way these twenty amino acids are arranged dictates the folding of the protein into its primary, secondary, tertiary, and quaternary structure. Since protein function is based on the ability to recognize and bind to specific molecules, having the correct shape is critical for proteins to do their jobs correctly. Learn more about the relationship between protein structure and function in this video.
The anti-inflammatory potential of an oral p38 MAPK inhibitor in humans in vivo suggests that p38 MAPK inhibitors may provide a new therapeutic option in the treatment of inflammatory diseases. Boehringer Ingelheim. 2002 Branger J, et al
The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan)1. The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.
Innovative. Technically superior. Creative. Reliable. These are words researchers use to describe Pierce, a pioneer and leader in many research disciplines including protein chemistry, sample handling, immunology and chromatography.
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY. Judith Branger, Bernt van den Blink, Sebastiaan Weijer, Abhya Gupta, Sander J.H. van Deventer, C. Erik Hack, Maikel P. Peppelenbosch, and Tom van der Poll
Men older than 50 with androgen deficiency are at a greater risk for all-cause mortality than their peers with age-appropriate testosterone, reported investigators here.
T. Malinauskas, T. Peer, B. Bishop, T. Mueller, and C. Siebold. Proc Natl Acad Sci U S A, 117 (27):
15620-15631(2020)Malinauskas, Tomas
Peer, Tina V
Bishop, Benjamin
Mueller, Thomas D
Siebold, Christian
eng
26752/CRUK_/Cancer Research UK/United Kingdom
C20724/A26752/CRUK_/Cancer Research UK/United Kingdom
WT_/Wellcome Trust/United Kingdom
203852/Z/16/2/WT_/Wellcome Trust/United Kingdom
14414/CRUK_/Cancer Research UK/United Kingdom
C20724/A14414/CRUK_/Cancer Research UK/United Kingdom
Research Support, Non-U.S. Gov't
2020/06/25
Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15620-15631. doi: 10.1073/pnas.2000561117. Epub 2020 Jun 23..