Pro-inflammatory eicosanoids and cytokines are produced from arachidonic acid, and omega-3s have been shown to inhibit arachidonic acid metabolism, hence less pro-inflammatory synthesis. Understand how to use fish oils to prevent chronic disease.
JPEN: Journal of Parenteral and Enteral Nutrition: Synergistic Anti-Inflammatory Activity of [omega]-3 Lipid and Rofecoxib Pretreatment on Macrophage Proinflammatory Cytokine Production Occurs via Divergent NF-[kappa]B Activation/Discussant/Author's Reply