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1The implications of biomarker evidence for systematic reviews.
M. Choong, and G. Tsafnat. BMC medical research methodology, 12 (1): 176 (January 2012)JID: 100968545; 2012/08/07 received; 2012/11/22 accepted; 2012/11/22 aheadofprint; aheadofprint;.
2 years ago by @jepcastel
show all tags
BiologicalMarkers
ClinicalTrialsasTopic
DecisionMaking
Evidence-BasedMedicine
Evidence-BasedMedicine:methods
Humans
Physician'sPracticePatterns
Prognosis
ReviewLiteratureasTopic
TreatmentOutcome
RCT
BiologicalMarkersClinicalTrialsasTopicDecisionMakingEvidence-BasedMedicineEvidence-BasedMedicine:methodsHumansPhysician'sPracticePatternsPrognosisReviewLiteratureasTopicTreatmentOutcomeRCT
(0)
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1Treatment effects on patient-important outcomes can be small, even with large effects on surrogate markers.
S. Walter, X. Sun, D. Heels-Ansdell, and G. Guyatt. Journal of clinical epidemiology, 65 (9): 940-5 (September 2012)6788<m:linebreak></m:linebreak>CI: Copyright (c) 2012; JID: 8801383; 2011/08/25 received; 2012/02/15 revised; 2012/02/19 accepted; 2012/05/18 aheadofprint; ppublish;<m:linebreak></m:linebreak>Tamaño del efecto; Surrogate endpoints.
2 years ago by @jepcastel
show all tags
BiologicalMarkers
BiologicalMarkers:analysis
HepatitisB
HepatitisB:therapy
HepatitisBeAntigens
HepatitisBeAntigens:analysis
Humans
ImmunologicFactors
ImmunologicFactors:therapeuticuse
Interferon-alpha
Interferon-alpha:therapeuticuse
Lamivudine
Lamivudine:therapeuticuse
LiverCirrhosis
LiverCirrhosis:etiology
LiverNeoplasms
LiverNeoplasms:etiology
OutcomeAssessment(HealthCare)
OutcomeAssessment(HealthCare):methods
RandomizedControlledTrialsasTopic:standards
ReverseTranscriptaseInhibitors
ReverseTranscriptaseInhibitors:therapeuticuse
RCT
BiologicalMarkersBiologicalMarkers:analysisHepatitisBHepatitisB:therapyHepatitisBeAntigensHepatitisBeAntigens:analysisHumansImmunologicFactorsImmunologicFactors:therapeuticuseInterferon-alphaInterferon-alpha:therapeuticuseLamivudineLamivudine:therapeuticuseLiverCirrhosisLiverCirrhosis:etiologyLiverNeoplasmsLiverNeoplasms:etiologyOutcomeAssessment(HealthCare)OutcomeAssessment(HealthCare):methodsRandomizedControlledTrialsasTopic:standardsReverseTranscriptaseInhibitorsReverseTranscriptaseInhibitors:therapeuticuseRCT
(0)
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1Comments on methodological problems related to the use of biomarkers in clinical practice and research.
D. Longrois, M. Agavriloaia, Y. Devaux, and P. Mertes. Annales françaises d'anesthèsie et de rèanimation, 28 (5): 473-81 (May 2009)5311<m:linebreak></m:linebreak>JID: 8213275; 0 (Biological Markers); RF: 36; 2009/02/09 received; 2009/02/23 accepted; 2009/05/01 aheadofprint; ppublish;<m:linebreak></m:linebreak>Proves diagnòstiques.
2 years ago by @jepcastel
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Animals
BiologicalMarkers
BiomedicalResearch
BiomedicalResearch:methods
BiomedicalResearch:trends
DataInterpretation
Humans
Research
Research:trends
ResearchDesign
Statistical
AnimalsBiologicalMarkersBiomedicalResearchBiomedicalResearch:methodsBiomedicalResearch:trendsDataInterpretationHumansResearchResearch:trendsResearchDesignStatistical
(0)
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1Surrogate end points in secondary analyses of cardiovascular trials.
K. Buhr. Progress in cardiovascular diseases, 54 (4): 343-50 (2012)7059<m:linebreak></m:linebreak>CI: Copyright (c) 2012; JID: 0376442; 0 (Biological Markers); ppublish;.
2 years ago by @jepcastel
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BiologicalMarkers
CardiovascularDiseases
CardiovascularDiseases:therapy
ClinicalTrialsasTopic
ClinicalTrialsasTopic:standards
Humans
ResearchDesign
StatisticsasTopic
StatisticsasTopic:standards
ValidationStudiesasTopic
BiologicalMarkersCardiovascularDiseasesCardiovascularDiseases:therapyClinicalTrialsasTopicClinicalTrialsasTopic:standardsHumansResearchDesignStatisticsasTopicStatisticsasTopic:standardsValidationStudiesasTopic
(0)
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1Clinical effectiveness in cardiovascular trials in relation to the importance to the patient of the end-points measured.
R. Bowater, and R. Lilford. Journal of evaluation in clinical practice, 17 (4): 547-53 (August 2011)6317<m:linebreak></m:linebreak>CI: (c) 2010; JID: 9609066; 2010/07/13 aheadofprint; ppublish;<m:linebreak></m:linebreak>Comparacions múltiples; Composite endpoints; CV.
2 years ago by @jepcastel
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BiologicalMarkers
CardiovascularDiseases
CardiovascularDiseases:prevention&control
CardiovascularDiseases:therapy
DatabasesasTopic
EndpointDetermination
Humans
RandomizedControlledTrialsasTopic:statistics
TreatmentOutcome
RCT
BiologicalMarkersCardiovascularDiseasesCardiovascularDiseases:prevention&controlCardiovascularDiseases:therapyDatabasesasTopicEndpointDeterminationHumansRandomizedControlledTrialsasTopic:statisticsTreatmentOutcomeRCT
(0)
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1Performance measures for prediction models and markers: evaluation of predictions and classifications.
E. Steyerberg, B. Calster, and M. Pencina. Revista española de cardiología, 64 (9): 788-94 (September 2011)6490<br/>CI: Copyright (c) 2011; JID: 0404277; 0 (Biological Markers); 0 (Cholesterol, HDL); 2011/04/25 received; 2011/04/26 accepted; 2011/07/16 aheadofprint; ppublish;<br/>Models predictius; Proves diagnòstiques; Introductori.
2 years ago by @jepcastel
show all tags
AreaUnderCurve
BiologicalMarkers
Calibration
Cardiology
Cardiology:methods
Cardiology:statistics&numericaldata
Cholesterol
DataInterpretation
DecisionSupportTechniques
Forecasting
Forecasting:methods
HDL
HDL:blood
HeartDiseases
HeartDiseases:classification
Humans
Models
ProportionalHazardsModels
ROCCurve
Statistical
AreaUnderCurveBiologicalMarkersCalibrationCardiologyCardiology:methodsCardiology:statistics&numericaldataCholesterolDataInterpretationDecisionSupportTechniquesForecastingForecasting:methodsHDLHDL:bloodHeartDiseasesHeartDiseases:classificationHumansModelsProportionalHazardsModelsROCCurveStatistical
(0)
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1Testing the incremental predictive accuracy of new markers.
C. Begg, M. Gonen, and V. Seshan. Clinical trials (London, England), 10 (5): 690-2 (October 2013)Models predictius; Proves diagnòstiques; ROC.
2 years ago by @jepcastel
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BiologicalMarkers
ClinicalTrialsasTopic
ClinicalTrialsasTopic:methods
Humans
PredictiveValueofTests
ROCCurve
ReproducibilityofResults
RiskAssessment
BiologicalMarkersClinicalTrialsasTopicClinicalTrialsasTopic:methodsHumansPredictiveValueofTestsROCCurveReproducibilityofResultsRiskAssessment
(0)
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1ROC curve inference for best linear combination of two biomarkers subject to limits of detection.
N. Perkins, E. Schisterman, and A. Vexler. Biometrical journal. Biometrische Zeitschrift, 53 (3): 464-76 (May 2011)6649<m:linebreak></m:linebreak>CI: Copyright (c) 2011; JID: 7708048; 0 (Biological Markers); 0 (Environmental Pollutants); 0 (Polychlorinated Biphenyls); ppublish;<m:linebreak></m:linebreak>Online; Proves diagnòstiques; ROC; LoD; R.
2 years ago by @jepcastel
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BiologicalMarkers
BiologicalMarkers:analysis
DataInterpretation
Endometriosis
Endometriosis:chemicallyinduced
EnvironmentalPollutants
EnvironmentalPollutants:poisoning
Female
Humans
LimitofDetection
Models
PolychlorinatedBiphenyls
PolychlorinatedBiphenyls:poisoning
ROCCurve
Statistical
BiologicalMarkersBiologicalMarkers:analysisDataInterpretationEndometriosisEndometriosis:chemicallyinducedEnvironmentalPollutantsEnvironmentalPollutants:poisoningFemaleHumansLimitofDetectionModelsPolychlorinatedBiphenylsPolychlorinatedBiphenyls:poisoningROCCurveStatistical
(0)
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1Assessing new biomarkers and predictive models for use in clinical practice: a clinician's guide.
K. McGeechan, P. Macaskill, L. Irwig, G. Liew, and T. Wong. Archives of internal medicine, 168 (21): 2304-10 (November 2008)4871<br/>JID: 0372440; 0 (Biological Markers); ppublish;<br/>Models predictius; Avaluació de riscs.
2 years ago by @jepcastel
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BiologicalMarkers
BiologicalMarkers:analysis
CardiovascularDiseases
CardiovascularDiseases:classification
CardiovascularDiseases:diagnosis
CardiovascularDiseases:epidemiology
Female
Humans
Male
Models
Prognosis
RiskAssessment
Statistical
BiologicalMarkersBiologicalMarkers:analysisCardiovascularDiseasesCardiovascularDiseases:classificationCardiovascularDiseases:diagnosisCardiovascularDiseases:epidemiologyFemaleHumansMaleModelsPrognosisRiskAssessmentStatistical
(0)
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2Extensions to decision curve analysis, a novel method for evaluating diagnostic tests, prediction models and molecular markers.
A. Vickers, A. Cronin, E. Elkin, and M. Gonen. BMC medical informatics and decision making, (January 2008)4678<m:linebreak></m:linebreak>JID: 101088682; 2008/06/03 received; 2008/11/26 accepted; 2008/11/26 aheadofprint; epublish;<m:linebreak></m:linebreak>Proves diagnòstiques.
2 years ago by @jepcastel
show all tags
BiologicalMarkers
BiologicalMarkers:analysis
Clinical
ComputerSimulation
ConfidenceIntervals
DecisionSupportSystems
DecisionSupportTechniques
DiagnosticTests
Humans
LogisticModels
Male
MolecularBiology
PredictiveValueofTests
Probability
ProstaticNeoplasms
ProstaticNeoplasms:diagnosis
Routine
BiologicalMarkersBiologicalMarkers:analysisClinicalComputerSimulationConfidenceIntervalsDecisionSupportSystemsDecisionSupportTechniquesDiagnosticTestsHumansLogisticModelsMaleMolecularBiologyPredictiveValueofTestsProbabilityProstaticNeoplasmsProstaticNeoplasms:diagnosisRoutine
(0)
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1Measuring molecular biomarkers in epidemiologic studies: laboratory techniques and biospecimen considerations.
H. Erickson. Statistics in medicine, 31 (22): 2400-13 (September 2012)6669<m:linebreak></m:linebreak>CI: Copyright (c) 2012; JID: 8215016; aheadofprint;<m:linebreak></m:linebreak>Epidemiologia genètica.
2 years ago by @jepcastel
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BiologicalMarkers
BiologicalMarkers:analysis
ClinicalLaboratoryTechniques
ClinicalLaboratoryTechniques:instrumentation
ClinicalLaboratoryTechniques:methods
EpidemiologicMethods
Humans
SpecimenHandling
SpecimenHandling:instrumentation
SpecimenHandling:methods
BiologicalMarkersBiologicalMarkers:analysisClinicalLaboratoryTechniquesClinicalLaboratoryTechniques:instrumentationClinicalLaboratoryTechniques:methodsEpidemiologicMethodsHumansSpecimenHandlingSpecimenHandling:instrumentationSpecimenHandling:methods
(0)
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1Expectations, validity, and reality in gene expression profiling.
K. Kim, S. Zakharkin, and D. Allison. Journal of clinical epidemiology, 63 (9): 950-9 (September 2010)7117<m:linebreak></m:linebreak>LR: 20110913; GR: P01 AG025532-02/AG/NIA NIH HHS/United States; GR: P01 AG025532-03/AG/NIA NIH HHS/United States; GR: P01AG025532/AG/NIA NIH HHS/United States; GR: P30 DK056336-05/DK/NIDDK NIH HHS/United States; GR: P30DK056336/DK/NIDDK NIH HHS/United States; JID: 8801383; 0 (Biological Markers); NIHMS199602; OID: NLM: NIHMS199602; OID: NLM: PMC2910173; 2009/06/11 received; 2010/02/09 revised; 2010/02/11 accepted; 2010/06/25 aheadofprint; ppublish;<m:linebreak></m:linebreak>Epidemiologia genètica.
2 years ago by @jepcastel
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BiologicalMarkers
ClinicalTrialsasTopic
Databases
GeneExpressionProfiling
GeneExpressionProfiling:instrumentation
GeneExpressionProfiling:methods
Genetic
Genetic:genetics
Humans
InformationStorageandRetrieval
InformationStorageandRetrieval:methods
MicroarrayAnalysis
MicroarrayAnalysis:methods
Neoplasms
Neoplasms:diagnosis
Neoplasms:genetics
ReproducibilityofResults
Transcription
BiologicalMarkersClinicalTrialsasTopicDatabasesGeneExpressionProfilingGeneExpressionProfiling:instrumentationGeneExpressionProfiling:methodsGeneticGenetic:geneticsHumansInformationStorageandRetrievalInformationStorageandRetrieval:methodsMicroarrayAnalysisMicroarrayAnalysis:methodsNeoplasmsNeoplasms:diagnosisNeoplasms:geneticsReproducibilityofResultsTranscription
(0)
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1Surrogate end points as a clinical and public health problem. The cerivastatin case.
J. Gérvas, and M. Fernández. Medicina clínica, 119 (7): 254-9 (September 2002)4311<m:linebreak></m:linebreak>LR: 20071115; PUBM: Print; JID: 0376377; 0 (Biological Markers); 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors); 0 (Pyridines); 0 (cerivastatin); ppublish;<m:linebreak></m:linebreak>Anàlisi de dades.
2 years ago by @jepcastel
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BiologicalMarkers
ClinicalTrialsasTopic
Humans
Hydroxymethylglutaryl-CoAReductaseInhibitors
Hydroxymethylglutaryl-CoAReductaseInhibitors:ad
Hydroxymethylglutaryl-CoAReductaseInhibitors:th
Pyridines
Pyridines:adverseeffects
Pyridines:therapeuticuse
Risk
TreatmentOutcome
BiologicalMarkersClinicalTrialsasTopicHumansHydroxymethylglutaryl-CoAReductaseInhibitorsHydroxymethylglutaryl-CoAReductaseInhibitors:adHydroxymethylglutaryl-CoAReductaseInhibitors:thPyridinesPyridines:adverseeffectsPyridines:therapeuticuseRiskTreatmentOutcome
(0)
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1Comparison of effect sizes associated with biomarkers reported in highly cited individual articles and in subsequent meta-analyses.
J. Ioannidis, and O. Panagiotou. JAMA : the journal of the American Medical Association, 305 (21): 2200-10 (June 2011)6172<m:linebreak></m:linebreak>JID: 7501160; 0 (Biological Markers); CIN: JAMA. 2011 Jun 1;305(21):2229-30. PMID: 21632488; ppublish;.
2 years ago by @jepcastel
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BiologicalMarkers
BiologicalMarkers:analysis
DataInterpretation
EffectModifier
Epidemiologic
Humans
Meta-AnalysisasTopic
RiskAssessment
SampleSize
Statistical
BiologicalMarkersBiologicalMarkers:analysisDataInterpretationEffectModifierEpidemiologicHumansMeta-AnalysisasTopicRiskAssessmentSampleSizeStatistical
(0)
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1Biomarkers and surrogate endpoints in clinical trials.
T. Fleming, and J. Powers. Statistics in medicine, 31 (25): 2973-84 (November 2012)6717<m:linebreak></m:linebreak>Mesures de resultats; Surrogate endpoints; RCT.
2 years ago by @jepcastel
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BiologicalMarkers
ClinicalTrialsasTopic
EndpointDetermination
Humans
OutcomeandProcessAssessment(HealthCare)
ReproducibilityofResults
ResearchDesign
BiologicalMarkersClinicalTrialsasTopicEndpointDeterminationHumansOutcomeandProcessAssessment(HealthCare)ReproducibilityofResultsResearchDesign
(0)
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1A statistician's perspective on biomarkers in drug development.
M. Jenkins, A. Flynn, T. Smart, C. Harbron, T. Sabin, J. Ratnayake, P. Delmar, A. Herath, P. Jarvis, and J. Matcham. Pharmaceutical statistics, 10 (6): 494-507 (2011)6456<m:linebreak></m:linebreak>Mesures de resultats; Surrogate endpoints.
2 years ago by @jepcastel
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BiologicalMarkers
BiologicalMarkers:analysis
DrugDiscovery
DrugDiscovery:statistics&numericaldata
Humans
IndividualizedMedicine
IndividualizedMedicine:methods
IndividualizedMedicine:statistics&numericalda
ResearchDesign
ResearchDesign:statistics&numericaldata
ToxicityTests
ToxicityTests:statistics&numericaldata
BiologicalMarkersBiologicalMarkers:analysisDrugDiscoveryDrugDiscovery:statistics&numericaldataHumansIndividualizedMedicineIndividualizedMedicine:methodsIndividualizedMedicine:statistics&numericaldaResearchDesignResearchDesign:statistics&numericaldataToxicityTestsToxicityTests:statistics&numericaldata
(0)
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1Weak associations between prognostic biomarkers and disease in preliminary studies illustrates the breach between statistical significance and diagnostic discrimination.
S. Levinson. Clinica chimica acta; international journal of clinical chemistry, 411 (7-8): 467-73 (April 2010)5593<m:linebreak></m:linebreak>CI: 2010; JID: 1302422; 0 (Biological Markers); RF: 64; 2009/11/19 received; 2010/01/08 revised; 2010/01/11 accepted; 2010/01/18 aheadofprint; ppublish;<m:linebreak></m:linebreak>Proves diagnòstiques.
2 years ago by @jepcastel
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BiologicalMarkers
BiologicalMarkers:analysis
DataInterpretation
Disease
Humans
OddsRatio
Prognosis
RiskFactors
SensitivityandSpecificity
Statistical
BiologicalMarkersBiologicalMarkers:analysisDataInterpretationDiseaseHumansOddsRatioPrognosisRiskFactorsSensitivityandSpecificityStatistical
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1Sample size for biomarker studies: more subjects or more measurements per subject?
D. Lai, T. King, L. Moyé, and Q. Wei. Annals of epidemiology, 13 (3): 204-8 (March 2003)3153<m:linebreak></m:linebreak>Sample size; Surrogate endpoints; Dades longitudinals.
2 years ago by @jepcastel
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Adult
Aged
Aging
BasalCell
BasalCell:epidemiology
BasalCell:genetics
BiologicalMarkers
BiologicalMarkers:analysis
Carcinoma
CostControl
DNARepair
EpidemiologicStudies
Humans
MiddleAged
ReproducibilityofResults
ResearchDesign
SampleSize
AdultAgedAgingBasalCellBasalCell:epidemiologyBasalCell:geneticsBiologicalMarkersBiologicalMarkers:analysisCarcinomaCostControlDNARepairEpidemiologicStudiesHumansMiddleAgedReproducibilityofResultsResearchDesignSampleSize
(0)
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1Tips for learners of evidence-based medicine: 5. The effect of spectrum of disease on the performance of diagnostic tests.
V. Montori, P. Wyer, T. Newman, S. Keitz, and G. Guyatt. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 173 (4): 385-90 (August 2005)3902<m:linebreak></m:linebreak>Proves diagnòstiques.
2 years ago by @jepcastel
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BiologicalMarkers
BiologicalMarkers:analysis
ClinicalMedicine
ClinicalMedicine:standards
Diagnosis
DiagnosticTests
Differential
Evidence-BasedMedicine
Humans
Prevalence
RiskFactors
Routine
SensitivityandSpecificity
BiologicalMarkersBiologicalMarkers:analysisClinicalMedicineClinicalMedicine:standardsDiagnosisDiagnosticTestsDifferentialEvidence-BasedMedicineHumansPrevalenceRiskFactorsRoutineSensitivityandSpecificity
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1Representation of exposures in regression analysis and interpretation of regression coefficients: basic concepts and pitfalls.
K. Leffondré, K. Jager, J. Boucquemont, V. Stel, and G. Heinze. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 29 (10): 1806-14 (October 2014)Anàlisi de dades; Nefrologia; Introductori.
2 years ago by @jepcastel
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80andover
Adult
AgeFactors
Aged
BiologicalMarkers
BiologicalMarkers:metabolism
BodyMassIndex
Chronic
Chronic:epidemiology
Chronic:metabolism
CohortStudies
DataInterpretation
Female
GlomerularFiltrationRate
Humans
LinearModels
LogisticModels
Male
MiddleAged
MultivariateAnalysis
ProportionalHazardsModels
RegressionAnalysis
RenalInsufficiency
SexFactors
Statistical
80andoverAdultAgeFactorsAgedBiologicalMarkersBiologicalMarkers:metabolismBodyMassIndexChronicChronic:epidemiologyChronic:metabolismCohortStudiesDataInterpretationFemaleGlomerularFiltrationRateHumansLinearModelsLogisticModelsMaleMiddleAgedMultivariateAnalysisProportionalHazardsModelsRegressionAnalysisRenalInsufficiencySexFactorsStatistical
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1The implications of biomarker evidence for systematic reviews.

1Treatment effects on patient-important outcomes can be small, even with large effects on surrogate markers.

1Comments on methodological problems related to the use of biomarkers in clinical practice and research.

1Surrogate end points in secondary analyses of cardiovascular trials.

1Clinical effectiveness in cardiovascular trials in relation to the importance to the patient of the end-points measured.

1Performance measures for prediction models and markers: evaluation of predictions and classifications.

1Testing the incremental predictive accuracy of new markers.

1ROC curve inference for best linear combination of two biomarkers subject to limits of detection.

1Assessing new biomarkers and predictive models for use in clinical practice: a clinician's guide.

2Extensions to decision curve analysis, a novel method for evaluating diagnostic tests, prediction models and molecular markers.

1Measuring molecular biomarkers in epidemiologic studies: laboratory techniques and biospecimen considerations.

1Expectations, validity, and reality in gene expression profiling.

1Surrogate end points as a clinical and public health problem. The cerivastatin case.

1Comparison of effect sizes associated with biomarkers reported in highly cited individual articles and in subsequent meta-analyses.

1Biomarkers and surrogate endpoints in clinical trials.

1A statistician's perspective on biomarkers in drug development.

1Weak associations between prognostic biomarkers and disease in preliminary studies illustrates the breach between statistical significance and diagnostic discrimination.

1Sample size for biomarker studies: more subjects or more measurements per subject?

1Tips for learners of evidence-based medicine: 5. The effect of spectrum of disease on the performance of diagnostic tests.

1Representation of exposures in regression analysis and interpretation of regression coefficients: basic concepts and pitfalls.

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