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1SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials.
A. Chan, J. Tetzlaff, P. Gøtzsche, D. Altman, H. Mann, J. Berlin, K. Dickersin, A. Hróbjartsson, K. Schulz, W. Parulekar and 3 other author(s). BMJ (Clinical research ed.), (January 2013)7139<m:linebreak></m:linebreak>JID: 8900488; OID: NLM: PMC3541470; epublish;<m:linebreak></m:linebreak>Protocol; RCT.
2 years ago by @jepcastel
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Checklist
ClinicalProtocols
ClinicalProtocols:standards
ClinicalTrialsDataMonitoringCommittees
ClinicalTrialsasTopic
ClinicalTrialsasTopic:methods
ClinicalTrialsasTopic:standards
ClinicalTrialsasTopic:statistics&numericald
ComputerSecurity
DataCollection
DataCollection:methods
Ethics
Humans
Medical
MedicalAudit
PatientSelection
PracticeGuidelinesasTopic
ProfessionalRole
QualityControl
RandomAllocation
ResearchDesign
ResearchPersonnel
ResearchSupportasTopic
SampleSize
SocialResponsibility
StatisticsasTopic
TimeFactors
TreatmentOutcome
ChecklistClinicalProtocolsClinicalProtocols:standardsClinicalTrialsDataMonitoringCommitteesClinicalTrialsasTopicClinicalTrialsasTopic:methodsClinicalTrialsasTopic:standardsClinicalTrialsasTopic:statistics&numericaldComputerSecurityDataCollectionDataCollection:methodsEthicsHumansMedicalMedicalAuditPatientSelectionPracticeGuidelinesasTopicProfessionalRoleQualityControlRandomAllocationResearchDesignResearchPersonnelResearchSupportasTopicSampleSizeSocialResponsibilityStatisticsasTopicTimeFactorsTreatmentOutcome
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1Reliable assessment of the effects of treatment on mortality and major morbidity, I: clinical trials.
R. Collins, and S. MacMahon. Lancet, 357 (9253): 373-80 (February 2001)2949<m:linebreak></m:linebreak>Mesures de contrast.
2 years ago by @jepcastel
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ClinicalTrialsasTopic
ClinicalTrialsasTopic:statistics&numericald
DataInterpretation
EpidemiologicFactors
Epidemiology
Epidemiology:statistics&numericaldata
Evidence-BasedMedicine
Evidence-BasedMedicine:statistics&numericalda
Humans
ResearchDesign
Statistical
ClinicalTrialsasTopicClinicalTrialsasTopic:statistics&numericaldDataInterpretationEpidemiologicFactorsEpidemiologyEpidemiology:statistics&numericaldataEvidence-BasedMedicineEvidence-BasedMedicine:statistics&numericaldaHumansResearchDesignStatistical
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1Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: the CANNeCTIN Biostatistics and Methodological Innovation Working Group.
L. Thabane, G. Wells, R. Cook, R. Platt, J. Pogue, E. Pullenayegum, D. Matthews, T. McCready, P. Devereaux, J. Cairns and 1 other author(s). Trials, (January 2011)6243<m:linebreak></m:linebreak>GR: Canadian Institutes of Health Research/Canada; JID: 101263253; OID: NLM: PMC3049182; 2010/11/14 received; 2011/02/18 accepted; 2011/02/18 aheadofprint; epublish;<m:linebreak></m:linebreak>Recursos/Organització; Consulting.
2 years ago by @jepcastel
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BiomedicalResearch
BiomedicalResearch:organization&administration
BiomedicalResearch:statistics&numericaldata
Biostatistics
Canada
CapacityBuilding
CardiovascularDiseases
CardiovascularDiseases:therapy
ClinicalTrialsasTopic
ClinicalTrialsasTopic:statistics&numericald
CongressesasTopic
DataInterpretation
DiabetesMellitus
DiabetesMellitus:therapy
HealthServicesResearch
HealthServicesResearch:organization&administr
HealthServicesResearch:statistics&numericald
Humans
InformationDissemination
Mentors
OrganizationalObjectives
ProgramDevelopment
Statistical
TreatmentOutcome
Videoconferencing
BiomedicalResearchBiomedicalResearch:organization&administrationBiomedicalResearch:statistics&numericaldataBiostatisticsCanadaCapacityBuildingCardiovascularDiseasesCardiovascularDiseases:therapyClinicalTrialsasTopicClinicalTrialsasTopic:statistics&numericaldCongressesasTopicDataInterpretationDiabetesMellitusDiabetesMellitus:therapyHealthServicesResearchHealthServicesResearch:organization&administrHealthServicesResearch:statistics&numericaldHumansInformationDisseminationMentorsOrganizationalObjectivesProgramDevelopmentStatisticalTreatmentOutcomeVideoconferencing
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1Do multiple outcome measures require p-value adjustment?
R. Feise. BMC medical research methodology, 2 (1): 8 (June 2002)2716<m:linebreak></m:linebreak>Comparacions múltiples.
2 years ago by @jepcastel
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ClinicalTrialsasTopic
ClinicalTrialsasTopic:methods
ClinicalTrialsasTopic:statistics&numericald
ConfidenceIntervals
DataInterpretation
Humans
Statistical
TreatmentOutcome
ClinicalTrialsasTopicClinicalTrialsasTopic:methodsClinicalTrialsasTopic:statistics&numericaldConfidenceIntervalsDataInterpretationHumansStatisticalTreatmentOutcome
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1Clinical versus statistical considerations in the design and analysis of clinical research.
R. Horwitz, B. Singer, R. Makuch, and C. Viscoli. Journal of clinical epidemiology, 51 (4): 305-7 (April 1998)2897<m:linebreak></m:linebreak>Comparacions múltiples.
2 years ago by @jepcastel
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ClinicalTrialsasTopic
ClinicalTrialsasTopic:methods
ClinicalTrialsasTopic:statistics&numericald
DataInterpretation
Humans
ResearchDesign
Statistical
ClinicalTrialsasTopicClinicalTrialsasTopic:methodsClinicalTrialsasTopic:statistics&numericaldDataInterpretationHumansResearchDesignStatistical
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1ICH-E9 reflections and considerations.
F. Rockhold, and S. Ruberg. Pharmaceutical statistics, 7 (4): 233-5 (2008)4692<m:linebreak></m:linebreak>JID: 101201192; ppublish;<m:linebreak></m:linebreak>Anàlisi de dades.
2 years ago by @jepcastel
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AnniversariesandSpecialEvents
Chemistry
ClinicalTrialsasTopic
ClinicalTrialsasTopic:standards
ClinicalTrialsasTopic:statistics&numericald
Humans
Pharmaceutical
Pharmaceutical:standards
Pharmaceutical:statistics&numericaldata
ResearchDesign
ResearchDesign:standards
AnniversariesandSpecialEventsChemistryClinicalTrialsasTopicClinicalTrialsasTopic:standardsClinicalTrialsasTopic:statistics&numericaldHumansPharmaceuticalPharmaceutical:standardsPharmaceutical:statistics&numericaldataResearchDesignResearchDesign:standards
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1Meta-analyses of chronic disease trials with competing causes of death may yield biased odds ratios.
M. Koller, T. Stijnen, E. Steyerberg, and J. Lubsen. Journal of clinical epidemiology, 61 (4): 365-72 (April 2008)4586<m:linebreak></m:linebreak>PUBM: Print-Electronic; JID: 8801383; 2006/05/23 received; 2007/05/08 revised; 2007/05/10 accepted; 2007/10/15 aheadofprint; ppublish;<m:linebreak></m:linebreak>Mesures d'associació.
2 years ago by @jepcastel
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Bias(Epidemiology)
CauseofDeath
ChronicDisease
ClinicalTrialsasTopic
ClinicalTrialsasTopic:statistics&numericald
DataInterpretation
Humans
Meta-AnalysisasTopic
OddsRatio
ResearchDesign
Statistical
TreatmentOutcome
RCT
Bias(Epidemiology)CauseofDeathChronicDiseaseClinicalTrialsasTopicClinicalTrialsasTopic:statistics&numericaldDataInterpretationHumansMeta-AnalysisasTopicOddsRatioResearchDesignStatisticalTreatmentOutcomeRCT
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1Breaking up is hard to do: the heartbreak of dichotomizing continuous data.
D. Streiner. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 47 (3): 262-6 (April 2002)5206<m:linebreak></m:linebreak>LR: 20071115; JID: 7904187; CIN: Can J Psychiatry. 2002 Nov;47(9):886. PMID: 12500760; CIN: Can J Psychiatry. 2003 Jul;48(6):429-30; author reply 430. PMID: 12894624; ppublish;<m:linebreak></m:linebreak>Anàlisi de dades; Categorització.
2 years ago by @jepcastel
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Bias(Epidemiology)
ClinicalTrialsasTopic
ClinicalTrialsasTopic:statistics&numericald
DataInterpretation
Humans
OutcomeAssessment(HealthCare)
OutcomeAssessment(HealthCare):statistics&num
PsychiatricStatusRatingScales
PsychiatricStatusRatingScales:statistics&num
Psychometrics
Statistical
Bias(Epidemiology)ClinicalTrialsasTopicClinicalTrialsasTopic:statistics&numericaldDataInterpretationHumansOutcomeAssessment(HealthCare)OutcomeAssessment(HealthCare):statistics&numPsychiatricStatusRatingScalesPsychiatricStatusRatingScales:statistics&numPsychometricsStatistical
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1Statistics review 10: further nonparametric methods.
V. Bewick, L. Cheek, and J. Ball. Critical care (London, England), 8 (3): 196-9 (June 2004)15153238<m:linebreak></m:linebreak> <m:linebreak></m:linebreak>PUBM: Print-Electronic; DEP: 20040416; JID: 9801902; 2004/04/16 aheadofprint; ppublish;<m:linebreak></m:linebreak> <m:linebreak></m:linebreak>Anàlisi de dades.
2 years ago by @jepcastel
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ClinicalTrialsasTopic
ClinicalTrialsasTopic:methods
ClinicalTrialsasTopic:statistics&numericald
DataInterpretation
Humans
Nonparametric
ResearchDesign
Statistical
Statistics
ClinicalTrialsasTopicClinicalTrialsasTopic:methodsClinicalTrialsasTopic:statistics&numericaldDataInterpretationHumansNonparametricResearchDesignStatisticalStatistics
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1Mathematics. Bayes' theorem in the 21st century.
B. Efron. Science (New York, N.Y.), 340 (6137): 1177-8 (June 2013)7390<m:linebreak></m:linebreak>JID: 0404511; ppublish;<m:linebreak></m:linebreak>Mètodes bayessians; Introductori.
2 years ago by @jepcastel
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Algorithms
BayesTheorem
ClinicalTrialsasTopic
ClinicalTrialsasTopic:statistics&numericald
Humans
Male
OligonucleotideArraySequenceAnalysis
OligonucleotideArraySequenceAnalysis:statistic
ProstaticNeoplasms
ProstaticNeoplasms:genetics
AlgorithmsBayesTheoremClinicalTrialsasTopicClinicalTrialsasTopic:statistics&numericaldHumansMaleOligonucleotideArraySequenceAnalysisOligonucleotideArraySequenceAnalysis:statisticProstaticNeoplasmsProstaticNeoplasms:genetics
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1Statistical significance testing and clinical trials.
M. Krause. Psychotherapy (Chicago, Ill.), 48 (3): 217-22 (September 2011)7061<m:linebreak></m:linebreak>CI: (c) 2011; JID: 2984829R; CIN: Psychotherapy (Chic). 2011 Sep;48(3):229-30; discussion 234-6. PMID: 21875237; CIN: Psychotherapy (Chic). 2011 Sep;48(3):225-8; discussion 234-6. PMID: 21875236; CIN: Psychotherapy (Chic). 2011 Sep;48(3):223-4; discussion 234-6. PMID: 21875235; CIN: Psychotherapy (Chic). 2011 Sep;48(3):231-3; discussion 234-6. PMID: 21875238; ppublish;.
2 years ago by @jepcastel
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ClinicalTrialsasTopic
ClinicalTrialsasTopic:statistics&numericald
Humans
OutcomeAssessment(HealthCare)
OutcomeAssessment(HealthCare):methods
Psychotherapy
Psychotherapy:methods
Psychotherapy:statistics&numericaldata
RandomizedControlledTrialsasTopic:statistics
ResearchDesign
ResearchDesign:statistics&numericaldata
RCT
ClinicalTrialsasTopicClinicalTrialsasTopic:statistics&numericaldHumansOutcomeAssessment(HealthCare)OutcomeAssessment(HealthCare):methodsPsychotherapyPsychotherapy:methodsPsychotherapy:statistics&numericaldataRandomizedControlledTrialsasTopic:statisticsResearchDesignResearchDesign:statistics&numericaldataRCT
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1Are these data real? Statistical methods for the detection of data fabrication in clinical trials.
S. Al-Marzouki, S. Evans, T. Marshall, and I. Roberts. BMJ (Clinical research ed.), 331 (7511): 267-70 (July 2005)3850<m:linebreak></m:linebreak>Anàlisi de dades.
2 years ago by @jepcastel
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Adult
CardiovascularDiseases
CardiovascularDiseases:prevention&control
Chi-SquareDistribution
ClinicalTrialsasTopic
ClinicalTrialsasTopic:standards
ClinicalTrialsasTopic:statistics&numericald
DataCollection
DataCollection:standards
DataCollection:statistics&numericaldata
DataInterpretation
Diet
Humans
MiddleAged
MulticenterStudiesasTopic
RandomAllocation
RandomizedControlledTrialsasTopic:standards
ScientificMisconduct
ScientificMisconduct:statistics&numericaldata
Statistical
RCT
AdultCardiovascularDiseasesCardiovascularDiseases:prevention&controlChi-SquareDistributionClinicalTrialsasTopicClinicalTrialsasTopic:standardsClinicalTrialsasTopic:statistics&numericaldDataCollectionDataCollection:standardsDataCollection:statistics&numericaldataDataInterpretationDietHumansMiddleAgedMulticenterStudiesasTopicRandomAllocationRandomizedControlledTrialsasTopic:standardsScientificMisconductScientificMisconduct:statistics&numericaldataStatisticalRCT
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1Why ünderpowered" trials are not necessarily unethical.
S. Edwards, R. Lilford, D. Braunholtz, and J. Jackson. Lancet, 350 (9080): 804-7 (September 1997)3460<m:linebreak></m:linebreak>Mesures de contrast.
2 years ago by @jepcastel
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ClinicalTrialsasTopic
ClinicalTrialsasTopic:statistics&numericald
EthicalAnalysis
Ethics
EthicsCommittees
FalseNegativeReactions
FalsePositiveReactions
Humans
Medical
Research
ResearchSubjects
SampleSize
TherapeuticHumanExperimentation
ClinicalTrialsasTopicClinicalTrialsasTopic:statistics&numericaldEthicalAnalysisEthicsEthicsCommitteesFalseNegativeReactionsFalsePositiveReactionsHumansMedicalResearchResearchSubjectsSampleSizeTherapeuticHumanExperimentation
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1Selection bias in observational and experimental studies.
J. Ellenberg. Statistics in medicine, 13 (5-7): 557-67 (1994)2785<m:linebreak></m:linebreak>Mesures d'associació.
2 years ago by @jepcastel
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ClinicalTrialsasTopic
ClinicalTrialsasTopic:statistics&numericald
CohortStudies
Humans
PatientDropouts
PatientDropouts:statistics&numericaldata
RandomizedControlledTrialsasTopic:statistics
SelectionBias
TreatmentOutcome
RCT
ClinicalTrialsasTopicClinicalTrialsasTopic:statistics&numericaldCohortStudiesHumansPatientDropoutsPatientDropouts:statistics&numericaldataRandomizedControlledTrialsasTopic:statisticsSelectionBiasTreatmentOutcomeRCT
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1Graphical approaches to the analysis of safety data from clinical trials.
O. Amit, R. Heiberger, and P. Lane. Pharmaceutical statistics, 7 (1): 20-35 (2008)4522<m:linebreak></m:linebreak>PUBM: Print; CI: (c) 2007; JID: 101201192; ppublish;<m:linebreak></m:linebreak>Presentació de dades.
2 years ago by @jepcastel
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ClinicalTrialsasTopic
ClinicalTrialsasTopic:statistics&numericald
ComputerGraphics
DataInterpretation
DrugTherapy
DrugTherapy:adverseeffects
HeartRate
HeartRate:drugeffects
Humans
InformationDissemination
Liver
Liver:drugeffects
LiverFunctionTests
ResearchDesign
RiskAssessment
Statistical
TimeFactors
ClinicalTrialsasTopicClinicalTrialsasTopic:statistics&numericaldComputerGraphicsDataInterpretationDrugTherapyDrugTherapy:adverseeffectsHeartRateHeartRate:drugeffectsHumansInformationDisseminationLiverLiver:drugeffectsLiverFunctionTestsResearchDesignRiskAssessmentStatisticalTimeFactors
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1Planning a reproducibility study: how many subjects and how many replicates per subject for an expected width of the 95 per cent confidence interval of the intraclass correlation coefficient.
B. Giraudeau, and J. Mary. Statistics in medicine, 20 (21): 3205-14 (November 2001)5343<m:linebreak></m:linebreak>LR: 20071115; CI: Copyright 2001; JID: 8215016; ppublish;<m:linebreak></m:linebreak>Sample size; Mesures de concordància.
2 years ago by @jepcastel
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Biometry
ClinicalTrialsasTopic
ClinicalTrialsasTopic:statistics&numericald
ConfidenceIntervals
Humans
OutcomeAssessment(HealthCare)
ReproducibilityofResults
SampleSize
BiometryClinicalTrialsasTopicClinicalTrialsasTopic:statistics&numericaldConfidenceIntervalsHumansOutcomeAssessment(HealthCare)ReproducibilityofResultsSampleSize
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1Preservation of effect and the regulatory approval of new treatments on the basis of non-inferiority trials.
S. Snapinn, and Q. Jiang. Statistics in medicine, 27 (3): 382-91 (February 2008)4443<m:linebreak></m:linebreak>PUBM: Print; JID: 8215016; ppublish;<m:linebreak></m:linebreak>Tests d'equivalència.
2 years ago by @jepcastel
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ClinicalTrialsasTopic
ClinicalTrialsasTopic:methods
ClinicalTrialsasTopic:statistics&numericald
Humans
Investigational
Investigational:statistics&numericaldata
Models
Statistical
Therapies
TreatmentOutcome
UnitedStates
ClinicalTrialsasTopicClinicalTrialsasTopic:methodsClinicalTrialsasTopic:statistics&numericaldHumansInvestigationalInvestigational:statistics&numericaldataModelsStatisticalTherapiesTreatmentOutcomeUnitedStates
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1Generalisation and extrapolation.
D. Altman, and J. Bland. BMJ (Clinical research ed.), 317 (7155): 409-10 (August 1998)2776<m:linebreak></m:linebreak>Generalització.
2 years ago by @jepcastel
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AnalysisofVariance
ClinicalTrialsasTopic
ClinicalTrialsasTopic:statistics&numericald
DataInterpretation
Statistical
AnalysisofVarianceClinicalTrialsasTopicClinicalTrialsasTopic:statistics&numericaldDataInterpretationStatistical
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1Clinical trials: discerning hype from substance.
T. Fleming. Annals of internal medicine, 153 (6): 400-6 (September 2010)6152<m:linebreak></m:linebreak>GR: R37 AI 29168/AI/NIAID NIH HHS/United States; JID: 0372351; ppublish; Molt bo<m:linebreak></m:linebreak>Critical appraisal; RCT; Comparacions múltiples; Regression to the mean.
2 years ago by @jepcastel
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ClinicalTrialsasTopic
ClinicalTrialsasTopic:standards
ClinicalTrialsasTopic:statistics&numericald
DataInterpretation
Evidence-BasedMedicine
Evidence-BasedMedicine:standards
Evidence-BasedMedicine:statistics&numericalda
Goals
HealthServicesResearch
HealthServicesResearch:standards
HealthServicesResearch:statistics&numericald
Humans
Statistical
ClinicalTrialsasTopicClinicalTrialsasTopic:standardsClinicalTrialsasTopic:statistics&numericaldDataInterpretationEvidence-BasedMedicineEvidence-BasedMedicine:standardsEvidence-BasedMedicine:statistics&numericaldaGoalsHealthServicesResearchHealthServicesResearch:standardsHealthServicesResearch:statistics&numericaldHumansStatistical
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1The analysis of clinical studies: the analysis of count data, part I.
S. Debanne, and D. Rowland. Gastrointestinal endoscopy, 54 (4): 546-7 (October 2001)2846<m:linebreak></m:linebreak>Anàlisi de dades.
2 years ago by @jepcastel
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Chi-SquareDistribution
ClinicalTrialsasTopic
ClinicalTrialsasTopic:statistics&numericald
Humans
Chi-SquareDistributionClinicalTrialsasTopicClinicalTrialsasTopic:statistics&numericaldHumans
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1SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials.

1Reliable assessment of the effects of treatment on mortality and major morbidity, I: clinical trials.

1Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: the CANNeCTIN Biostatistics and Methodological Innovation Working Group.

1Do multiple outcome measures require p-value adjustment?

1Clinical versus statistical considerations in the design and analysis of clinical research.

1ICH-E9 reflections and considerations.

1Meta-analyses of chronic disease trials with competing causes of death may yield biased odds ratios.

1Breaking up is hard to do: the heartbreak of dichotomizing continuous data.

1Statistics review 10: further nonparametric methods.

1Mathematics. Bayes' theorem in the 21st century.

1Statistical significance testing and clinical trials.

1Are these data real? Statistical methods for the detection of data fabrication in clinical trials.

1Why ünderpowered" trials are not necessarily unethical.

1Selection bias in observational and experimental studies.

1Graphical approaches to the analysis of safety data from clinical trials.

1Planning a reproducibility study: how many subjects and how many replicates per subject for an expected width of the 95 per cent confidence interval of the intraclass correlation coefficient.

1Preservation of effect and the regulatory approval of new treatments on the basis of non-inferiority trials.

1Generalisation and extrapolation.

1Clinical trials: discerning hype from substance.

1The analysis of clinical studies: the analysis of count data, part I.

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