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Open access. Psychological treatment is recommended for depression and anxiety in those with epilepsy. This review used standardised criteria to evaluate, for the first time, the clinical relevance of any symptom change these treatments afford patients.
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Open access. Epilepsy is a serious condition which can profoundly affect an individual’s life. While there is some evidence to suggest an association between antidepressant use and epilepsy and seizures it is conflicting and not conclusive. Antidepressant prescribing is rising in the UK so it is important to quantify absolute risks with individual antidepressants to enable shared decision making with patients. In this study we assess and quantify the association between antidepressant treatment and the risk of epilepsy and seizures in a large cohort of patients diagnosed with depression aged between 20 and 64 years.
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A disturbed circadian rhythm seems to be a causal factor in the occurrence of depressive disorders in patients with Parkinson’s disease (PD). The circadian rhythm can be restored with light. Therefore, Bright Light Therapy (BLT) might be a new treatment option for depression in PD patients.
Anxiety is a common neuropsychiatric symptom in Parkinson’s disease (PD), yet the neural mechanisms have been scarcely investigated. Disturbances in dopaminergic and serotonergic signalling may play a role in its pathophysiology. To read the full article, log in using your NHS OpenAthens details.
Advancements in the management of FND emphasise a ‘rule-in’ diagnosis and roles for cognitive behavioural therapy (CBT)1 and physical therapy (PT).2 Neuroimaging studies have also started delineating the neuropathophysiology of FND.3 In the same cohort as this present study, we previously identified that impaired mental health and increased trait anxiety correlated with individual differences in amygdalar volume in patients with FND, while diminished physical functioning was associated with reduced anterior insular volume.4 In FND, the magnitude of adverse life event burden also correlated with decreased insular and hippocampal volumes.5. To read the full article, log in using your NHS OpenAthens details.
Open access. Our study shows that the Dutch ADAMS is a reliable and valid instrument for adults aged between 18 and 49 years with intellectual disabilities (and comorbid epilepsy).
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Depression is among the most common and debilitating non‐motor complaints in Parkinson's disease (PD), yet there is a paucity of controlled research to guide treatment. Little research has focused on the extent to which specific depressive symptom profiles may dictate unique clinical recommendations to ultimately improve treatment outcomes. The current study examined the impact of Cognitive‐Behavioral Therapy (CBT) on different types of depressive symptoms in PD. It was hypothesized that the cognitive (e.g., guilt, rumination, negative attitudes towards self) and behavioral (e.g., avoidance, procrastination) symptoms targeted most intensively by the treatment protocol would show the most robust response. The extent to which stabilized antidepressant use moderated specific symptom change was examined on an exploratory basis.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Question Does the severity of incident depression influence a patient’s risk of developing epilepsy?
Findings When used as a surrogate for depression severity, analyses stratified by antidepressant treatment type demonstrate a clear, statistically significant gradient in the hazard of epilepsy and the odds of seizure outcomes.
Meaning Using depression treatment as a surrogate of severity, we found that worsening depression appears to augment the risk of epilepsy and the odds of worse seizure outcomes. Future prospective studies designed to address causation between depression and epilepsy are warranted.
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Open access. In the field of Parkinson disease (PD) research, many studies have shown that deep brain stimulation (DBS) can soften side effects, which arise during long‐term medical therapy. This study focuses on the changes in depressive symptoms, quality of life (with the subdivisions physical and mental health), activities of daily living, and subjective memory functioning in PD patients testing the baseline and the outcome 1 year after DBS.
“Why should we require better ‘number needed to treat’ statistics from psychological than from pharmacological treatments?”
Reading the title of the study by Noble et al 1 in Journal of Neurology, Neurosurgery and Psychiatry, ‘Cognitive-behavioural therapy does not meaningfully reduce depression in most people with epilepsy: a systematic review with a reliable change analysis’, stakeholders in ‘Psychotherapy Incorporated’ may wonder whether they need to rush to their stockbroker and sell their cognitive-behavioural therapy (CBT) shares. They need not hurry—but they will need to read the whole paper or this comment.
The pooled findings of the meta-analysis by Noble et al of five randomised controlled studies in which at least some elements of CBT were used to treat depression or anxiety in patients with epilepsy demonstrate that the chances of reliable improvement according …..... To read the full article, log in using your NHS OpenAthens details.
To systematically review and analyze the efficacy and tolerability of different antidepressant pharmacologic treatments for depressive symptoms in Parkinson's disease (PD). To read the full article, log in using your SSSFT NHS OpenAthens details. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
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