Letter. The concept of “treatment resistance” has become all the rage in depression research. It is used to define populations in research studies and in treatment algorithms as a rationale for moving on from standard antidepressants to other therapies. In such algorithms, electroconvulsive therapy (ECT) is often bundled improperly with less effective neurostimulation‐methods and experimental pharmacotherapies.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
It's important to note that this is experimental, early-stage research. The study lacked a control group, so it's hard to know whether the improvement in mood, or the changes seen on MRI scans, can be attributed to the drug.
Late-life depressive symptoms have been extensively studied for their relationship with incident dementia, but have been typically assessed at a single timepoint. Such an approach neglects the course of depression, which, given its remitting and relapsing nature, might provide further insights into the complex association of depression with dementia. We therefore repeatedly measured depressive symptoms in a population of adults over a decade to study the subsequent risk of dementia. Please contact the library to receive a copy of this article - http://bit.ly/1Xyazai
Seasonal affective disorder (SAD) is common and debilitating. The standard of care includes light therapy provided by a light box; however, this treatment is restrictive and only moderately effective. Advances in LED technology enable lighting solutions that emit vastly more light than traditional light boxes. Here, we assess the feasibility of BROAD (Bright, whole-ROom, All-Day) light therapy and get a first estimate for its potential effectiveness.
A range of free courses to support people who are dealing with anxiety, stress and depression are being offered throughout Herefordshire.
Let’s Talk is an Improving Access to Psychological Therapy (IAPT) service and is part of 2gether NHS Foundation Trust. The courses provide education on topics related to stress, anxiety and depression, and cover practical techniques and tips to help people learn to manage their mood.
The courses run for four to eight weeks, are run by friendly and professional staff, and are open to anyone who wishes to use them. Some courses are only available for people registered with a Herefordshire GP.
Blog post about this recent systematic review by Woody et al. (2017) aimed to give an up-to-date summary of the prevalence and incidence of perinatal depression. In their review, Woody et al. also examined factors which might explain the difference in depression prevalence estimates between studies, such as whether the study was conducted during pregnancy or the postnatal period, and where the study was conducted.
Psychostimulant augmentation is considered a potential treatment strategy for individuals with major depressive disorder who do not adequately respond to antidepressant monotherapy. The primary objective of this 12-month open-label extension study was to evaluate the safety and tolerability of lisdexamfetamine dimesylate (LDX) as augmentation therapy to an antidepressant in adults with major depressive disorder.. MPFT staff can use the OVID link, or you can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
There are many effective psychological therapies to help teenagers with depression, anxiety or other mental health problems. Unfortunately, for various reasons, most teenagers never get access to a professional therapist. To overcome this problem, some researchers are exploring the potential of brief, “single-session” interventions that can be delivered cheaply and easily to many at-risk teenagers outside of a clinical context. In The Journal of Child Psychology and Psychiatry, Jessica Schleider and John Weisz at Harvard University present extremely promising results from their trial of a 30-minute computer session teaching depressed and anxious teenagers that personality is malleable.
The Treatment-Resistant Depression Registry investigated whether adjunctive vagus nerve stimulation (VNS) with treatment as usual in depression has superior long-term outcomes compared with treatment as usual only. Login at top right hand side of page using your SSSFT NHS Athens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Accessible summary:
Older people with learning disabilities who develop memory problems are likely to feel sad.
There is much information showing how people with learning disabilities can learn new behaviours which help them to think differently and feel better.
This is the story of how I helped one older man with learning disabilities and memory problems to change how he was behaving and feel happier. Login using your SSSFT NHS Athens for full text. SSOTP - request a copy of the article from the library http://www.sssft.nhs.uk/library
Commentary on:
Rentala S, Fong TC, Nattala P, et al. Effectiveness of body-mind-spirit intervention on well-being, functional impairment and quality of life among depressive patients—a randomized controlled trial. J Adv Nurs 2015;71:2153–63.
Implications for practice and research
A body-mind-spirit (BMS) intervention with pharmacotherapy for depression can help patients manage their condition and increase their quality of life and well-being.
Nurses trained to deliver a BMS intervention to patients can play a critical role in providing integrated clinical care in a hospital setting.
Research on this intervention can make use of existing methods to further refine the efficiency and quality of the intervention programme being developed.
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A disturbed sense of self is a core feature of depression. The medial prefrontal cortex, which has a central role in self-appraisal processes, is often implicated in the illness, although it remains unclear how functional alterations of the region contribute to the observed disturbances. The aim of this study was to clarify the role of the medial prefrontal cortex in self-appraisal processes in depression. Login at top right hand side of page using your SSSFT NHS Athens for full text.
The authors sought to determine whether symptoms experienced by formerly depressed patients after at least 8 weeks of remission can be used to identify their risk for relapse during the next 6 months. Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Depression and anxiety are common, with one in six people experiencing symptoms in any given week. Of these people, 8.32 million are prescribed antidepressants. People living with HIV are likely to experience psychiatric disorder, with one in three experiencing depression and anxiety, and being at greater risk of developing post-traumatic stress disorder... This article seeks to raise awareness of sexual side-effects of psychotropic medications and draw attention to ethical issues related to post selective serotonin reuptake inhibitor sexual dysfunction (PSSD)
To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Impaired ability to recall specific autobiographical memories is characteristic of depression, which when reversed, may have therapeutic benefits. This cluster-randomized controlled pilot trial investigated efficacy and aspects of acceptability, and feasibility of MEmory Specificity Training (MEST) relative to Psychoeducation and Supportive Counselling (PSC) for Major Depressive Disorder (N = 62).. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Open access. People with a family history of major depressive disorder (MDD) or bipolar disorder (BD) report specific psychoeducational needs that are unmet by existing online interventions. This trial aimed to test whether an interactive website for people at familial risk for depression (intervention) would improve intention to adopt, or actual adoption of, depression prevention strategies (primary outcome) and a range of secondary outcome measures.
This review and consensus statement provides a general overview of the data on the use of ketamine for the treatment of mood disorders and highlights the limitations of the existing knowledge. While ketamine may be beneficial to some patients with mood disorders, it is important to consider the limitations of the available data and the potential risk associated with the drug when considering the treatment option. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
A disturbed circadian rhythm seems to be a causal factor in the occurrence of depressive disorders in patients with Parkinson’s disease (PD). The circadian rhythm can be restored with light. Therefore, Bright Light Therapy (BLT) might be a new treatment option for depression in PD patients.
Ketamine, an N-methyl-d-aspartate glutamate receptor antagonist, has demonstrated a rapid-onset antidepressant effect in patients with treatment-resistant depression. This study evaluated the efficacy of twice- and thrice-weekly intravenous administration of ketamine in sustaining initial antidepressant effects in patients with treatment-resistant depression. Login at top right hand side of page using your SSSFT NHS Athens for full text. SSOTP - request a copy of the article from the library http://bit.ly/1Xyazai
Psychiatric Rehabilitation Journal (May 14, 2018): No Pagination Specified
Objective: This study investigated the effects of manual-based Phenomenological Art Therapy for individuals living with depression in addition to treatment as usual (PATd/TAU) compared with only treatment as usual (TAU) for individuals diagnosed with moderate to severe depression.. To read the full article, log in using your NHS OpenAthens details.
Editorial. Login at top right hand side of page using your SSSFT NHS Athens for full text. SSOTP - request a copy of the article from the library http://bit.ly/1Xyazai
The aim of this study is to review the effectiveness of third wave mindfulness-based cognitive behavioral therapies (CBTs) for depressive or anxiety symptomatology in older adults across a wide range of physical and psychological conditions. Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Psychological Bulletin (Aug 8, 2016).
This meta-analysis evaluated the relation between social support and depression in youth and compared the cumulative evidence for 2 theories that have been proposed to explain this association: the general benefits (GB; also known as main effects) and stress-buffering (SB) models. To read the full article, log in using your NHS OpenAthens details.
To quantify the effect of laughter and humor interventions on depression, anxiety and sleep quality in adults.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Fear of negative evaluation (FNE) is a hallmark feature of social anxiety disorder (SAD). There is also evidence that people with SAD fear receiving positive evaluation, and that fear of positive evaluation (FPE) is distinct from FNE. However, researchers have speculated that concerns related to negative evaluation may actually underlie FPE. This study sought to advance our understanding of FPE by employing both quantitative and qualitative methods to assess the reasons underlying participants’ endorsement of FPE on the Fear of Positive Evaluation Scale (FPES; Weeks, Heimberg, & Rodebaugh, 2008) and the extent to which these reasons reflect FNE versus FPE in a sample of individuals with SAD (n = 47) and a nonclinical comparison group (n = 49). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Journal of Consulting and Clinical Psychology Vol. 86, Iss. 6, (Jun 2018): 493-504.
Objective: Internet-based cognitive–behavioral treatments (ICBT) have shown promise for various mental disorders, including social anxiety disorder (SAD). Most of these treatments have been delivered on desktop computers. However, the use of smartphones is becoming ubiquitous and could extend the reach of ICBT into users’ everyday life. Only a few studies have empirically examined the efficacy of ICBT delivered through a smartphone app and there is no published study on mobile app delivered ICBT for SAD. This three-arm randomized-controlled trial (RCT) is the first to compare the efficacy of guided ICBT for smartphones (app) and conventional computers (PC) with a wait list control group (WL).. To read the full article, log in using your NHS OpenAthens details.
A growing literature indicates that unipolar depression and bipolar depression are associated with alterations in grey matter volume. However, it is unclear to what degree these patterns of morphometric change reflect symptom dimensions. Here, we aimed to predict depressive symptoms and hypomanic symptoms based on patterns of grey matter volume using machine learning.. To read the full article, log in using your SSSFT NHS OpenAthens details. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Journal of Consulting and Clinical Psychology (Dec 20, 2018). DOI:10.1037/ccp0000364
Objective: Screening protocols that rely on a single informant are inadequate in predicting pediatric depression. Multi-informant and risk factor screening approaches are potentially more sensitive methods for identifying depression risk, but the incremental validity of these protocols has not been adequately tested.. To read the full article, log in using your NHS OpenAthens details.
This paper details a case study which explains how a woman with a mild learning disability was helped to confront overwhelming anxiety which she referred to as “the gremlin.” The client described how “the gremlin” was having an influence over her ability to manage in stressful situations and cope with change. A narrative approach was utilised which focussed on reducing the influence of “the gremlin.” . To read the full article, log in using your SSSFT NHS OpenAthens details. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
The evidence from multiple open-label trials documents the efficacy and safety of Deep brain stimulation (DBS) in the treatment of refractory depression (TRD).1 Nonetheless, randomised sham-control trials are required to determine whether the effect is directly related to active electrical stimulation or to the non-stimulation effects. To read the full article, log in using your NHS OpenAthens details
Chronic Fatigue Syndrome (CFS) is a debilitating condition that affects 0.2–0.4% of the population. First-line treatments are Cognitive Behaviour Therapy or graded exercise therapy; however, these treatments yield only moderate effect sizes. Emerging research suggests that anxiety about health may be common in CFS. Health anxiety treatment models demonstrate good therapeutic outcomes; however, these models have yet to be applied to CFS. This paper describes the application of a novel cognitive behavioural approach to the treatment of both physical and anxiety related symptoms in a patient with CFS and, furthermore, presents a conceptual hypothesis regarding the mutually maintaining relationship between these two co-occurring conditions. Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
The randomized phase (phase 2) of the Prolonging Remission in Depressed Elderly (PRIDE) study evaluated the efficacy and tolerability of continuation ECT plus medication compared with medication alone in depressed geriatric patients after a successful course of ECT (phase 1). Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Because of concerns about potential associations between high doses of citalopram and QTc prolongation in adults, this study examined whether such associations are operant in children. We hypothesized that therapeutic doses of nontricyclic antidepressant medications (non-TCAs) prescribed to children would be cardiovascularly safe. SSSFT staff can use the OVID link, or you can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
The process of worry has been associated with reductions in working memory capacity and availability of resources necessary for efficient attentional control. This, in turn, can lead to escalating worry. Recent investigations into working memory training have shown improvements in attentional control and cognitive performance in high trait-anxious individuals and individuals with sub-clinical depression. The current randomised controlled trial investigated the effects of 15 days of adaptive n-back working memory training, or an active control task, on working memory capacity, attentional control and worry in a sample of high worriers.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
To compare the efficacy of two antidepressant treatment strategies in severely depressed in-patients, that is, imipramine vs. venlafaxine, both with subsequent lithium addition in non-responders.Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Journal of Consulting and Clinical Psychology85.6 (Jun 2017): 596-610.
Objective: Anxiety sensitivity (AS) is a well-established transdiagnostic risk factor for anxiety and mood psychopathology including suicide. A variety of interventions using cognitive–behavioral skills as well as cognitive bias modification (CBM) suggest that AS can be quickly and effectively reduced in nonclinical and nontreatment seeking samples. However, it is unclear whether AS reduction protocols will have efficacy for more severe clinical samples. Moreover, the combination of cognitive–behavioral techniques with CBM focused on changing interpretation bias (CBM-I) related to AS has not been evaluated. To read the full article, log in using your NHS OpenAthens details.
Highlights: Attention bias modification (ABM) training for social anxiety was tested; 120 adolescents with social anxiety were treated with ABM or placebo training; ABM training did not alter attention bias to threat or social anxiety; Questions about the efficacy of ABMT as an intervention are raised. To read the full article, log in using your NHS OpenAthens details.
Clinical depression in children as young as age 3 has been validated, and prevalence rates are similar to the school-age disorder. Homotypic continuity between early and later childhood depression has been observed, with alterations in brain function and structure similar to those reported in depressed adults. These findings highlight the importance of identifying and treating depression as early as developmentally possible, given the relative treatment resistance and small effect sizes for treatments later in life. The authors conducted a randomized controlled trial of a dyadic parent-child psychotherapy for early childhood depression that focuses on enhancing the child’s emotional competence and emotion regulation.. Login at top right hand side of page using your MPFT NHS OpenAthens for full text. SSOTP (legacy account)- Please contact the library to receive a copy of this article - http://bit.ly/1Xyazai
A growing body of evidence suggests that internet-based cognitive behavioural treatments (ICBT) are effective to treat social anxiety disorder (SAD). Whereas the efficacy of clinician-guided ICBT has been established, ICBT in a group format has not yet been systematically investigated. This three-arm RCT compared the efficacy of clinician-guided group ICBT (GT) with clinician guided individual ICBT (IT) and a wait-list (WL). To read the full article, log in using your NHS OpenAthens details.
While mental health professionals have focused on concerns about whether antidepressants work on a neurochemical level it is important to understand the meaning this medication holds in the lives of people who use it. This study explores diversity in the experience of antidepressant users.
This article explores men's experiences of using peer support groups for coping with mental distress. To read the full article, log in using your NHS OpenAthens details.
Encouraging women and their partners to take time for self at least once a week in the first 6 months postpartum may promote positive parental mental health.
Future research examining the relationship between co-parenting and time for selfholds potential in the effort to prevent postpartum depression. To read the full article, log in using your NHS OpenAthens details
No studies have explored the acceptability of Behavioural Activation and Guided Self‐Help interventions for depression with people who have intellectual disabilities.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
The purpose of this essay is to introduce a threat‐based beliefs model of treatment‐seeking for depression through the discussion of facilitative threats (i.e. beliefs regarding the negative impact of depression on personal functioning that may facilitate treatment engagement) and to propose potential treatment strategies that mental health and psychiatric nurses can utilize to encourage their patients to receive treatment for depression. Considering mental health and psychiatric nurses play an important role in maintaining the mental health of their patients, this information could prove invaluable to assist nurses in helping their patients to not only receive treatment for their depression, but also to maintain their treatment‐seeking motivations. This essay will begin by discussing the staggering lack of treatment‐seeking for depression.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Anxiety is a common condition usually managed in general practice (GP) in the UK. GP patient records can be used for epidemiological studies of anxiety as well as clinical audit and service planning. However, it is not clear how general practitioners (GPs) conceptualise, diagnose and document anxiety in these records. We sought to understand these factors through an interview study with GPs. Open Access Article