While progress has been made in determining the molecular basis for
the circadian clock, the mechanism by which mammalian brains time
intervals measured in seconds to minutes remains a mystery. An obvious
question is whether the interval-timing mechanism shares molecular
machinery with the circadian timing mechanism. In the current study,
we trained circadian CLOCK +/− and −/− mutant male mice in a peak-interval
procedure with 10 and 20-s criteria. The mutant mice were more active
than their wild-type littermates, but there were no reliable deficits
in the accuracy or precision of their timing as compared with wild-type
littermates. This suggests that expression of the CLOCK protein is
not necessary for normal interval timing.
%0 Journal Article
%1 Cordes2008
%A Cordes, Sara
%A Gallistel, CR
%D 2008
%J Brain Research
%K chronobiology, timing
%P 120--127
%T Intact interval timing in circadian CLOCK mutants
%U http://dx.doi.org/10.1016/j.brainres.2008.06.043
%V 1227
%X While progress has been made in determining the molecular basis for
the circadian clock, the mechanism by which mammalian brains time
intervals measured in seconds to minutes remains a mystery. An obvious
question is whether the interval-timing mechanism shares molecular
machinery with the circadian timing mechanism. In the current study,
we trained circadian CLOCK +/− and −/− mutant male mice in a peak-interval
procedure with 10 and 20-s criteria. The mutant mice were more active
than their wild-type littermates, but there were no reliable deficits
in the accuracy or precision of their timing as compared with wild-type
littermates. This suggests that expression of the CLOCK protein is
not necessary for normal interval timing.
@article{Cordes2008,
__markedentry = {[freesurfer:6]},
abstract = {While progress has been made in determining the molecular basis for
the circadian clock, the mechanism by which mammalian brains time
intervals measured in seconds to minutes remains a mystery. An obvious
question is whether the interval-timing mechanism shares molecular
machinery with the circadian timing mechanism. In the current study,
we trained circadian CLOCK +/− and −/− mutant male mice in a peak-interval
procedure with 10 and 20-s criteria. The mutant mice were more active
than their wild-type littermates, but there were no reliable deficits
in the accuracy or precision of their timing as compared with wild-type
littermates. This suggests that expression of the CLOCK protein is
not necessary for normal interval timing.},
added-at = {2012-02-24T14:11:06.000+0100},
author = {Cordes, Sara and Gallistel, CR},
biburl = {https://www.bibsonomy.org/bibtex/294c85dbe443013e770d01f2e1f4f65c0/jakspa},
interhash = {490edeb13ea3b0068fe3c678191226ce},
intrahash = {94c85dbe443013e770d01f2e1f4f65c0},
issn = {00068993},
journal = {Brain Research},
keywords = {chronobiology, timing},
month = aug,
owner = {freesurfer},
pages = {120--127},
refid = {citeulike:10382050},
timestamp = {2012-02-24T14:11:07.000+0100},
title = {Intact interval timing in circadian CLOCK mutants},
url = {http://dx.doi.org/10.1016/j.brainres.2008.06.043},
volume = 1227,
year = 2008
}