tag :: Cell factors receptor mice

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4Real-time monitoring of somatostatin receptor-cAMP signaling in live pituitary
S. Jacobs, D. Calebiro, V. Nikolaev, M. Lohse, и S. Schulz. Endocrinology, 151 (9): 4560-5 (сентября 2010)Jacobs, Stefan Calebiro, Davide Nikolaev, Viacheslav O Lohse, Martin J Schulz, Stefan United States Endocrinology Endocrinology. 2010 Sep;151(9):4560-5. Epub 2010 Jul 7..
14 лет назад , @pharmawuerz
AMP/*metabolism
Animals
Cultured
Cyclic
Dynamics
Energy
Exchange
Factors
Factors/genetics/metabolism
Female
Fluorescence
G-Protein-Coupled/genetics/metabolism
Gland/cytology/*metabolism
Guanine
Knockout
Luminescent
Male
Mice
Molecular
Nucleotide
Pituitary
Proteins/genetics/metabolism
Resonance
Signal
Simulation
Somatostatin/genetics/*metabolism
Time
Transduction
Transfer/methods
Transgenic
Receptor
Cell
AMP/*metabolismAnimalsCulturedCyclicDynamicsEnergyExchangeFactorsFactors/genetics/metabolismFemaleFluorescenceG-Protein-Coupled/genetics/metabolismGland/cytology/*metabolismGuanineKnockoutLuminescentMaleMiceMolecularNucleotidePituitaryProteins/genetics/metabolismResonanceSignalSimulationSomatostatin/genetics/*metabolismTimeTransductionTransfer/methodsTransgenicReceptorCell
(0)
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2Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells
K. von Hayn, R. Werthmann, V. Nikolaev, L. Hommers, M. Lohse, и M. Bunemann. Am J Physiol Cell Physiol, 298 (2): C324-32 (февраля 2010)von Hayn, Kathrin Werthmann, Ruth C Nikolaev, Viacheslav O Hommers, Leif G Lohse, Martin J Bunemann, Moritz Research Support, Non-U.S. Gov't United States American journal of physiology. Cell physiology Am J Physiol Cell Physiol. 2010 Feb;298(2):C324-32. Epub 2009 Nov 4..
14 лет назад , @pharmawuerz
&
*Calcium
1/antagonists
AMP/*metabolism
Adenylate
Adrenergic
Animals
Aorta/enzymology
Biosensing
Cultured
Cyclase/antagonists
Cyclic
Dose-Response
Drug
Energy
Factors
Fluorescence
GTP-Binding
Gq-G11/*metabolism
Humans
Inhibitors/pharmacology
Interference
Isoenzymes/antagonists
Isoproterenol/pharmacology
Mice
Muscle,
Muscle/drug
Myocytes,
Nucleotide
Phosphodiesterase
Phosphodiesterases,
Protein
Purinergic/metabolism
RNA
Relationship,
Resonance
Signaling/drug
Smooth
Smooth,
Subunits,
Techniques
Time
Transfection
Transfer
Triphosphate/metabolism
Type
Uridine
Vascular/drug
Vasoconstriction
Vasodilation
Xanthines/pharmacology
alpha
beta-Agonists/pharmacology
effects
effects/*enzymology
inhibitors/genetics/*metabolism
inhibitors/metabolism
Receptor
Cell
&*Calcium1/antagonistsAMP/*metabolismAdenylateAdrenergicAnimalsAorta/enzymologyBiosensingCulturedCyclase/antagonistsCyclicDose-ResponseDrugEnergyFactorsFluorescenceGTP-BindingGq-G11/*metabolismHumansInhibitors/pharmacologyInterferenceIsoenzymes/antagonistsIsoproterenol/pharmacologyMiceMuscle,Muscle/drugMyocytes,NucleotidePhosphodiesterasePhosphodiesterases,ProteinPurinergic/metabolismRNARelationship,ResonanceSignaling/drugSmoothSmooth,Subunits,TechniquesTimeTransfectionTransferTriphosphate/metabolismTypeUridineVascular/drugVasoconstrictionVasodilationXanthines/pharmacologyalphabeta-Agonists/pharmacologyeffectseffects/*enzymologyinhibitors/genetics/*metabolisminhibitors/metabolismReceptorCell
(0)
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2Activation and deactivation kinetics of alpha 2A- and alpha 2C-adrenergic receptor-activated G protein-activated inwardly rectifying K+ channel currents
M. Bunemann, M. Bucheler, M. Philipp, M. Lohse, и L. Hein. J Biol Chem, 276 (50): 47512-7 (декабря 2001)Bunemann, M Bucheler, M M Philipp, M Lohse, M J Hein, L Research Support, Non-U.S. Gov't United States The Journal of biological chemistry J Biol Chem. 2001 Dec 14;276(50):47512-7. Epub 2001 Oct 8..
14 лет назад , @pharmawuerz
*Potassium
Action
Activation
Animals
Assay
Binding
Calcium
Cell
Channels
Channels,
Channels/*chemistry/metabolism
Channels/metabolism
Dose-Response
Drug
Electrophysiology
Enzyme
Factors
Fluorescence
G
GTP-Binding
Humans
Inwardly
Inwardly-Rectifying
Kinetics
Knockout
Line
Mice
Microscopy,
Norepinephrine/metabolism/pharmacology
Potassium
Potentials
Protein
Protein-Coupled
Proteins/metabolism
Radioligand
Rectifying
Relationship,
Signal
Time
Transduction
Transfection
alpha-2/*chemistry/*metabolism
alpha/metabolism
Receptor
Adrenergic
*PotassiumActionActivationAnimalsAssayBindingCalciumCellChannelsChannels,Channels/*chemistry/metabolismChannels/metabolismDose-ResponseDrugElectrophysiologyEnzymeFactorsFluorescenceGGTP-BindingHumansInwardlyInwardly-RectifyingKineticsKnockoutLineMiceMicroscopy,Norepinephrine/metabolism/pharmacologyPotassiumPotentialsProteinProtein-CoupledProteins/metabolismRadioligandRectifyingRelationship,SignalTimeTransductionTransfectionalpha-2/*chemistry/*metabolismalpha/metabolismReceptorAdrenergic
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1Cardiovascular failure in mouse embryos deficient in VEGF receptor-3
D. Dumont, L. Jussila, J. Taipale, A. Lymboussaki, T. Mustonen, K. Pajusola, M. Breitman, и K. Alitalo. Science, 282 (5390): 946-949 (1998)
15 лет назад , @kanefendt
Adult
Animals
Antigens
Blood
C
CD31
Cardiovascular
Cell
Chemistry
Development
Embryo
Embryonic
Endothelial
Endothelium
Factor
Factors
Fetal
Gene
Growth
Hematopoiesis
Heterozygote
Homozygote
Hybridization
Immunohistochemistry
In
Kinase
Kinases
Ligands
Lymphatic
Mammalian
Mice
Neovascularization
Physiologic
Protein-Tyrosine
Receptor
Receptor-3
Receptors
Research
Signal
Situ
Surface
System
Targeting
Transduction
Vascular
Vessels
analysis
and
blood
embryology
genetics
physiology
supply
AdultAnimalsAntigensBloodCCD31CardiovascularCellChemistryDevelopmentEmbryoEmbryonicEndothelialEndotheliumFactorFactorsFetalGeneGrowthHematopoiesisHeterozygoteHomozygoteHybridizationImmunohistochemistryInKinaseKinasesLigandsLymphaticMammalianMiceNeovascularizationPhysiologicProtein-TyrosineReceptorReceptor-3ReceptorsResearchSignalSituSurfaceSystemTargetingTransductionVascularVesselsanalysisandbloodembryologygeneticsphysiologysupply
(0)
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1Differential binding characteristics and cellular inhibition by soluble VEGF receptors 1 and 2
W. Roeckl, D. Hecht, H. Sztajer, J. Waltenberger, A. Yayon, и H. Weich. Exp.Cell Res., 241 (1): 161-170 (1998)
15 лет назад , @kanefendt
&
A
Agents
Animals
BALB
Binding
C
Cell
Cells
Cloning
Competitive
Cross-Linking
Dimerization
Endothelial
Expression
Factor
Factors
Fibrinolytic
Gene
Growth
Heparin
Human
Humans
Inbred
Kinase
Kinases
Ligands
Lymphokines
Mice
Mitogens
Molecular
Plastics
Proliferation
Protein
Protein-Tyrosine
Proteins
Proto-Oncogene
Reagents
Receptor
Receptor-1
Receptors
Research
Solubility
Tyrosine
Vascular
antagonists
cells
drug
effects
genetics
inhibitors
isolation
metabolism
pharmacology
protein
purification
&AAgentsAnimalsBALBBindingCCellCellsCloningCompetitiveCross-LinkingDimerizationEndothelialExpressionFactorFactorsFibrinolyticGeneGrowthHeparinHumanHumansInbredKinaseKinasesLigandsLymphokinesMiceMitogensMolecularPlasticsProliferationProteinProtein-TyrosineProteinsProto-OncogeneReagentsReceptorReceptor-1ReceptorsResearchSolubilityTyrosineVascularantagonistscellsdrugeffectsgeneticsinhibitorsisolationmetabolismpharmacologyproteinpurification
(0)
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1Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema
M. Karkkainen, R. Ferrell, E. Lawrence, M. Kimak, K. Levinson, M. McTigue, K. Alitalo, и D. Finegold. Nat.Genet., 25 (2): 153-159 (2000)
15 лет назад , @kanefendt
5
Activation
Alleles
Animals
C
Cell
Chemistry
Chromosomes
Data
Dominant
Endothelial
Enzyme
Factor
Factors
Female
Fusion
Genes
Growth
Half-Life
Human
Humans
Infant
Kinase
Kinases
Laboratories
Line
Lymphedema
Male
Mice
Missense
Models
Molecular
Mutation
Newborn
Pair
Pedigree
Phosphorylation
Protein
Protein-Tyrosine
Proteins
Receptor
Receptor-3
Receptors
Recombinant
Research
Sequence
Signal
Stability
Structure
Surface
Transcriptional
Transduction
Tyrosine
Vascular
congenital
drug
effects
genetics
metabolism
pharmacology
protein
secondary
5ActivationAllelesAnimalsCCellChemistryChromosomesDataDominantEndothelialEnzymeFactorFactorsFemaleFusionGenesGrowthHalf-LifeHumanHumansInfantKinaseKinasesLaboratoriesLineLymphedemaMaleMiceMissenseModelsMolecularMutationNewbornPairPedigreePhosphorylationProteinProtein-TyrosineProteinsReceptorReceptor-3ReceptorsRecombinantResearchSequenceSignalStabilityStructureSurfaceTranscriptionalTransductionTyrosineVascularcongenitaldrugeffectsgeneticsmetabolismpharmacologyproteinsecondary
(0)
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1Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors
A. Petit, J. Rak, M. Hung, P. Rockwell, N. Goldstein, B. Fendly, и R. Kerbel. Am.J.Pathol., 151 (6): 1523-1530 (1997)
15 лет назад , @kanefendt
A
Adenocarcinoma
Animals
Antibodies
Breast
Carcinoma
Cell
Cells
Cultured
Dose-Response
Down-Regulation
Drug
Endothelial
Epidermal
Expression
Factor
Factors
Gene
Growth
Human
Humans
Immunoenzyme
Lymphokines
Mice
Monoclonal
Neoplasm
Neoplasms
Neoplastic
Neovascularization
Neutralization
Nude
Oncogenes
Pathologic
Proliferation
Receptor
Regulation
Relationship
Research
Signal
Squamous
Survival
Techniques
Tests
Transduction
Transplantation
Tumor
Tyrosine
Vascular
blood
cells
drug
effects
erbB-2
immunology
metabolism
pathology
pharmacology
physiology
protein
therapy
AAdenocarcinomaAnimalsAntibodiesBreastCarcinomaCellCellsCulturedDose-ResponseDown-RegulationDrugEndothelialEpidermalExpressionFactorFactorsGeneGrowthHumanHumansImmunoenzymeLymphokinesMiceMonoclonalNeoplasmNeoplasmsNeoplasticNeovascularizationNeutralizationNudeOncogenesPathologicProliferationReceptorRegulationRelationshipResearchSignalSquamousSurvivalTechniquesTestsTransductionTransplantationTumorTyrosineVascularbloodcellsdrugeffectserbB-2immunologymetabolismpathologypharmacologyphysiologyproteintherapy
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1Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis
Y. Shaked, F. Bertolini, S. Man, M. Rogers, D. Cervi, T. Foutz, K. Rawn, D. Voskas, D. Dumont, Y. Ben-David и 6 other автор(ы). Cancer Cell, 7 (1): 101-111 (2005)
15 лет назад , @kanefendt
A
Angiogenesis
Animals
Antibodies
Assay
Biological
Cell
Cells
Cytometry
Dose-Response
Drug
Endothelial
Factor
Factors
Fibroblast
Flow
Growth
Humans
Inbred
Inhibitors
Male
Markers
Mice
Neovascularization
Pathologic
Phenotype
Receptor
Receptor-2
Relationship
Research
Stem
Strains
Survival
TIE-2
Transgenic
Vascular
analysis
blood
cells
drug
effects
genetics
metabolism
methods
pharmacology
physiology
therapy
AAngiogenesisAnimalsAntibodiesAssayBiologicalCellCellsCytometryDose-ResponseDrugEndothelialFactorFactorsFibroblastFlowGrowthHumansInbredInhibitorsMaleMarkersMiceNeovascularizationPathologicPhenotypeReceptorReceptor-2RelationshipResearchStemStrainsSurvivalTIE-2TransgenicVascularanalysisbloodcellsdrugeffectsgeneticsmetabolismmethodspharmacologyphysiologytherapy
(0)
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1Prediction of active drug plasma concentrations achieved in cancer patients by pharmacodynamic biomarkers identified from the geo human colon carcinoma xenograft model
F. Luo, Z. Yang, H. Dong, A. Camuso, K. McGlinchey, K. Fager, C. Flefleh, D. Kan, I. Inigo, S. Castaneda и 4 other автор(ы). Clin.Cancer Res., 11 (15): 5558-5565 (2005)
15 лет назад , @kanefendt
Agents
Animals
Antibodies
Antigen
Antineoplastic
Antitumor
Assay
Assays
Biological
Carcinoma
Cell
Chemistry
Colonic
Enzyme-Linked
Epidermal
Factor
Factors
Female
G
Growth
Human
Humans
Immunoglobulin
Immunohistochemistry
Immunosorbent
Ki-67
Kinase
Line
MAP
Markers
Mice
Model
Monoclonal
Neoplasm
Neoplasms
Nude
Pharmacokinetics
Phosphorylation
Receptor
Research
Signaling
System
Time
Transplantation
Tumor
Tyrosine
Xenograft
analysis
biosynthesis
drug
metabolism
methods
pathology
pharmacology
protein
response
therapy
AgentsAnimalsAntibodiesAntigenAntineoplasticAntitumorAssayAssaysBiologicalCarcinomaCellChemistryColonicEnzyme-LinkedEpidermalFactorFactorsFemaleGGrowthHumanHumansImmunoglobulinImmunohistochemistryImmunosorbentKi-67KinaseLineMAPMarkersMiceModelMonoclonalNeoplasmNeoplasmsNudePharmacokineticsPhosphorylationReceptorResearchSignalingSystemTimeTransplantationTumorTyrosineXenograftanalysisbiosynthesisdrugmetabolismmethodspathologypharmacologyproteinresponsetherapy
(0)
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1Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth
T. Karpanen, M. Egeblad, M. Karkkainen, H. Kubo, S. Yla-Herttuala, M. Jaattela, и K. Alitalo. Cancer Res., 61 (5): 1786-1790 (2001)
15 лет назад , @kanefendt
&
Animals
Blood
Breast
C
Carcinoma
Cell
Division
Endothelial
Factor
Factors
Female
Fusion
Growth
Heterologous
Human
Humans
Immunoglobulins
Kinase
Kinases
Laboratories
Lymphangiogenesis
Lymphatic
Mice
Neoplasm
Neoplasms
Neovascularization
Pathologic
Protein-Tyrosine
Proteins
Receptor
Receptor-3
Receptors
Recombinant
Research
Scid
System
Transfection
Transplantation
Vascular
Vessels
antagonists
biosynthesis
blood
cells
genetics
inhibitors
metabolism
pathology
physiology
physiopathology
protein
supply
&AnimalsBloodBreastCCarcinomaCellDivisionEndothelialFactorFactorsFemaleFusionGrowthHeterologousHumanHumansImmunoglobulinsKinaseKinasesLaboratoriesLymphangiogenesisLymphaticMiceNeoplasmNeoplasmsNeovascularizationPathologicProtein-TyrosineProteinsReceptorReceptor-3ReceptorsRecombinantResearchScidSystemTransfectionTransplantationVascularVesselsantagonistsbiosynthesisbloodcellsgeneticsinhibitorsmetabolismpathologyphysiologyphysiopathologyproteinsupply
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1Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3
T. Makinen, L. Jussila, T. Veikkola, T. Karpanen, M. Kettunen, K. Pulkkanen, R. Kauppinen, D. Jackson, H. Kubo, S. Nishikawa и 2 other автор(ы). Nat.Med., 7 (2): 199-205 (2001)
15 лет назад , @kanefendt
Animals
C
Cell
D
Endothelial
Factor
Factors
Growth
Human
Humans
Kinase
Kinases
Laboratories
Line
Lymph
Lymphangiogenesis
Lymphatic
Lymphedema
Mice
Neovascularization
Nodes
Pathologic
Phenotype
Protein-Tyrosine
Receptor
Receptor-3
Receptors
Research
Signal
Solubility
Transduction
Transgenic
Vascular
Vessels
blood
cells
genetics
metabolism
pathology
supply
AnimalsCCellDEndothelialFactorFactorsGrowthHumanHumansKinaseKinasesLaboratoriesLineLymphLymphangiogenesisLymphaticLymphedemaMiceNeovascularizationNodesPathologicPhenotypeProtein-TyrosineReceptorReceptor-3ReceptorsResearchSignalSolubilityTransductionTransgenicVascularVesselsbloodcellsgeneticsmetabolismpathologysupply
(0)
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1A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells
S. Koyanagi, Y. Kuramoto, H. Nakagawa, H. Aramaki, S. Ohdo, S. Soeda, и H. Shimeno. Cancer Res., 63 (21): 7277-7283 (2003)
15 лет назад , @kanefendt
&
(Genetics)
1
A
Angiogenesis
Animals
Aryl
Cell
Circadian
Cycle
DNA-Binding
Drosophila
Endothelial
Expression
Eye
Factor
Factors
Flavoproteins
G-Protein-Coupled
Gene
Genetic
Growth
Hydrocarbon
Hypoxia
Hypoxia-Inducible
ICR
Inbred
Inhibitors
Invertebrate
Japan
Male
Messenger
Mice
Neoplastic
Nuclear
Photoreceptors
Promoter
Proteins
RNA
Receptor
Receptors
Regions
Regulation
Research
Rhythm
Subunit
Transcription
Transfection
Translocator
Vascular
alpha
analysis
antagonists
biosynthesis
cells
genetics
inhibitors
metabolism
pharmacology
physiology
protein
response
therapy
&(Genetics)1AAngiogenesisAnimalsArylCellCircadianCycleDNA-BindingDrosophilaEndothelialExpressionEyeFactorFactorsFlavoproteinsG-Protein-CoupledGeneGeneticGrowthHydrocarbonHypoxiaHypoxia-InducibleICRInbredInhibitorsInvertebrateJapanMaleMessengerMiceNeoplasticNuclearPhotoreceptorsPromoterProteinsRNAReceptorReceptorsRegionsRegulationResearchRhythmSubunitTranscriptionTransfectionTranslocatorVascularalphaanalysisantagonistsbiosynthesiscellsgeneticsinhibitorsmetabolismpharmacologyphysiologyproteinresponsetherapy
(0)
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1Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
Y. He, K. Kozaki, T. Karpanen, K. Koshikawa, S. Yla-Herttuala, T. Takahashi, и K. Alitalo. J.Natl.Cancer Inst., 94 (11): 819-825 (2002)
15 лет назад , @kanefendt
&
Animals
Antibodies
Blotting
C
Cell
Cells
Cultured
D
Division
Endothelial
Expression
Factor
Factors
Female
Gene
Growth
Human
Humans
Kinase
Kinases
Laboratories
Line
Lung
Lymph
Lymphangiogenesis
Lymphatic
Metastasis
Mice
Neoplasm
Neoplasms
Neoplastic
Nodes
Protein-Tyrosine
RNA
Receptor
Receptor-3
Receptors
Regulation
Research
Scid
Signal
Time
Transduction
Transfection
Transplantation
Tumor
Vascular
Vessels
Western
antagonists
blood
cells
control
genetics
immunology
inhibitors
metabolism
methods
pathology
prevention
protein
secondary
supply
&AnimalsAntibodiesBlottingCCellCellsCulturedDDivisionEndothelialExpressionFactorFactorsFemaleGeneGrowthHumanHumansKinaseKinasesLaboratoriesLineLungLymphLymphangiogenesisLymphaticMetastasisMiceNeoplasmNeoplasmsNeoplasticNodesProtein-TyrosineRNAReceptorReceptor-3ReceptorsRegulationResearchScidSignalTimeTransductionTransfectionTransplantationTumorVascularVesselsWesternantagonistsbloodcellscontrolgeneticsimmunologyinhibitorsmetabolismmethodspathologypreventionproteinsecondarysupply
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4Real-time monitoring of somatostatin receptor-cAMP signaling in live pituitary

2Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells

2Activation and deactivation kinetics of alpha 2A- and alpha 2C-adrenergic receptor-activated G protein-activated inwardly rectifying K+ channel currents

1Cardiovascular failure in mouse embryos deficient in VEGF receptor-3

1Differential binding characteristics and cellular inhibition by soluble VEGF receptors 1 and 2

1Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema

1Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors

1Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis

1Prediction of active drug plasma concentrations achieved in cancer patients by pharmacodynamic biomarkers identified from the geo human colon carcinoma xenograft model

1Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth

1Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3

1A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells

1Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling

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