To examine the association between hearing aids (HAs) and time to diagnosis of Alzheimer disease (AD) or dementia, anxiety or depression, and injurious falls among adults, aged 66 years and older, within 3 years of hearing loss (HL) diagnosis.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
To investigate the presence of cerebral amyloidopathy and its associations with performances on neurocognitive tests and clinical features in depressed elders with mild cognitive impairment (MCI).. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Implications for research and practice:
> Active pain treatment improves sleep in people with dementia and depression.
> This study paves the way for improved methods; these results should be used as the basis for further exploration of this important issue.
> Future studies should include subjective evaluation of the benefits of pain treatment on sleep and explore improvements in related areas such as day-time functioning and falls. To read the full article, log in using your NHS OpenAthens details
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Systematic review and meta‐analysis to determine the effectiveness of interventions in reducing depressive symptoms in ethnic minority carers of people with dementia.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Commentary on: Osler M, Rozing MP, Christensen GT, et al. Electroconvulsive therapy and risk of dementia in patients with affective disorders: a cohort study. Lancet Psychiatry 2018;5:348–56.. To read the full article, log in using your NHS OpenAthens details.
We've added 10 new Be Aware updates following your suggestions:
Musculoskeletal ; Osteoporosis ; Nutrition and obesity ; Falls ; HR ; Research Methods ; Information Governance ; Bladder, bowel and pelvic healthcare ; Rheumatology ; Medicines and healthcare products regulatory agency (circulated email)
People should look out for signs of depression and dementia among older family members and friends over Christmas, NHS England expert Professor Alistair Burns urged today.
Problems that may have been hidden can come to the surface or be easier to spot as families or friends get together over the festive season, Prof Burns said.
Depression should not be written off as inevitable in old age and can be treated effectively. Emotional changes can also be the first indication that someone has dementia.
We'd like to hear your suggestions for new book alert topics. Simply reply to this email with 'Book Alert Topic' and your suggestions. You can also view and sign-up to our current new book alerts here: http://library.sssft.nhs.uk/librarykeepuptodate
Implications for research and practice:
> Active pain treatment improves sleep in people with dementia and depression.
> This study paves the way for improved methods; these results should be used as the basis for further exploration of this important issue.
> Future studies should include subjective evaluation of the benefits of pain treatment on sleep and explore improvements in related areas such as day-time functioning and falls. To read the full article, log in using your NHS OpenAthens details
Electroconvulsive therapy (ECT) is an effective treatment for severe depressive disorders, with older age being predictive of a better outcome. Two earlier small studies have suggested an increased prevalence of dementia in patients having received ECT, but were flawed by major methodological shortcomings. Recent data on both short-term and long-term impact of ECT on cognitive function in older patients are reassuring,1 even in the presence of age-related brain changes.2. To read the full article, log in using your NHS OpenAthens details.
Depression and cardiometabolic abnormalities are independently associated with a high risk of dementia. This study aimed to examine the association of comorbid depressive symptoms and cardiometabolic abnormalities with risk of dementia.. To read the full article, log in using your MPFT NHS OpenAthens details.
The aetiology of dementia is not yet fully understood. Stress can have a damaging effect on brain health. The prognostic effect of anxiety is still unclear regarding Alzheimer's disease as well as vascular dementia.. To read the full article, log in using your MPFT NHS OpenAthens details.
To evaluate whether clinically significant anxiety is an independent risk factor for dementia, taking into account both depression among potentially confounding factors and the competing risk of death.. To read the full article, log in using your MPFT NHS OpenAthens details.
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Letter. Login at top right hand side of page using your MPFT NHS OpenAthens for full text. SSOTP (legacy account)- Please contact the library to receive a copy of this article - http://bit.ly/1Xyazai
The classification of mild cognitive impairment (MCI) continues to be debated though it has recently been subtyped into late (LMCI) versus early (EMCI) stages. Older adults presenting with both a depressive disorder (DEP) and cognitive impairment (CI) represent a unique, understudied population. Our aim was to examine baseline characteristics of DEP‐CI patients in the DOTCODE trial, a randomized controlled trial of open antidepressant treatment for 16 weeks followed by add‐on donepezil or placebo for 62 weeks.. To read the full article, log in using your MPFT NHS OpenAthens details. SSOTP (legacy account) - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
We're expanding our Be Aware updates and want to know what physical health topics you'd like to keep updated on. Let us know your ideas by replying to this email with 'physical health topics' followed by your suggestions
To investigate the association between chronic subsyndromal symptoms of depression (SSD), cerebrospinal fluid (CSF) biomarkers, and neuropsychological performance in individuals with mild cognitive impairment (MCI).. To read the full article, log in using your MPFT NHS OpenAthens details. SSOTP (legacy account) - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Anxiety is an increasingly recognised predictor of cognitive deterioration in older adults and in those with mild cognitive impairment. Often believed to be a prodromal feature of neurodegenerative disease, anxiety may also be an independent risk factor for dementia, operationally defined here as preceding dementia diagnosis by ≥10 years.
Open Access Article
This study found that anticholinergic drugs were linked with about a 10% increase in the chances of dementia. However, not all anticholinergic drugs showed this effect. People who'd taken anticholinergic antidepressants, drugs for Parkinson's disease, and drugs used for urinary incontinence were more likely to have developed dementia. Those who'd taken anticholinergic drugs for cardiovascular or gastrointestinal conditions did not have an increased risk.
This type of study cannot show that anticholinergic drugs cause dementia.
Merete Osler and colleagues' Article on Electroconvulsive therapy and risk of dementia in patients with affective disorders comes, as do all Lancet Psychiatry papers, with a Research in Context panel. In this case, the cultural context, as well as the clinical background, is essential to understand the significance of the paper and to interpret its reception.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Electroconvulsive therapy (ECT) is the most effective treatment for severe episodes of mood disorders. Temporary memory loss is a common side-effect, but ongoing discussions exist regarding potential long-term adverse cognitive outcomes. Only a few studies have examined the frequency of dementia in patients after ECT. The aim of this study was to examine the association between ECT and risk of subsequent dementia in patients with a first-time hospital diagnosis of affective disorder.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
[Comment] Electroconvulsive therapy (ECT) remains a treatment that raises controversy despite its endorsement for specific indications by clinical guidelines such as those from the UK National Institute for Health and Care Excellence.1 Central to the controversy is disagreement over the balance between the potential benefits and harms of ECT, especially in a patient group whose severity of illness arguably makes them particularly vulnerable. In The Lancet Psychiatry, Merete Osler and colleagues2 report the findings from their cohort study of patients in Denmark with a first hospital contact for an affective disorder from 2005 to end of 2015, comparing the incidence of dementia in those who had received ECT with those who had not.
Letter. . To read the full article, log in using your SSSFT NHS OpenAthens details. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Depressive symptoms are common among people with dementia, impacting quality of life and cognitive and functional decline. Currently, little is known about the acceptability and feasibility of psychological interventions for people with mild dementia, with recent reviews identifying the need for further evidence. Developing and evaluating psychological interventions to prevent and treat these symptoms is, therefore, an important clinical and research priority. This protocol describes a study testing the acceptability and feasibility of a manual-based behavioural activation (BA) intervention for preventing and treating depressive symptoms in people with mild dementia. The aim of this study is to explore the feasibility of conducting a pragmatic multicentre randomised controlled trial of clinical effectiveness of an eight-session intervention. The Intervention to prevent Depressive symptoms and promote well-being in EArly-stage dementia (IDEA) programme supports people with dementia and their family carers in identifying and scheduling enjoyable and meaningful activities.
Open Access Article
To understand the role of depressive symptoms in preclinical Alzheimer’s disease, it is essential to define their temporal relationship to Alzheimer’s proteinopathies in cognitively normal older adults. The study objective was to examine associations of brain amyloid beta and longitudinal measures of depression and depressive symptom clusters in a cognitively normal sample of older adults. . Login at top right hand side of page using your SSSFT NHS OpenAthens for full text. SSOTP- Please contact the library to receive a copy of this article - http://bit.ly/1Xyazai
Does playing high school football have a statistically and clinically significant adverse association with cognitive impairment and depression at 65 years of age? Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Previous studies have indicated that dementia and depression have a considerable impact on the functional capacity of older adults, also influencing awareness about ability. The purpose of the current study was to investigate the impact of dementia, depression and awareness on activities of daily living (ADL) in a sample from a middle-income country. To read the full article, log in using your SSSFT NHS OpenAthens details.
Depressive and anxiety symptoms are common in older adults, significantly affect quality of life, and are risk factors for Alzheimer's disease. We sought to identify the determinants of predominant trajectories of depressive and anxiety symptoms in cognitively normal older adults. To read the full article, log in using your SSSFT NHS OpenAthens details.
The primary aim of this study is to describe depression and physical function in nursing home residents with dementia, as well as to examine the associations between depression and balance function, lower limb muscle strength, mobility and activities of daily living. The secondary aim is to examine the differences in physical function between the groups classified as depressed and not depressed.
Open Access Article
To characterize the trajectory of depressive symptoms over 28 years prior to dementia diagnosis to determine whether depressive symptoms carry risk for dementia. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Depression and dementia in elderly individuals have a complicated relationship. Cognitive changes are common in the context of depression, and mood symptoms frequently accompany cognitive disorders. This comorbidity represents a challenge for clinicians assessing older, functionally impaired patients with signs and symptoms of mood and cognitive disorders. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
We’ve just heard that SSOTP will not be renewing their agreement with SSSFT LKS for library services for this financial year. Because of this we will be reviewing our Be Aware bulletins. Sadly we won’t be accepting any new sign-ups from SSOTP staff and will be withdrawing some of the physical healthcare bulletins that we…
The Live Well Community Cafés will provide, fun, entertainment, advice and guidance to anyone living in south Staffordshire that has been diagnosed with or cares for someone with an illness or condition that has changed the way they live, whether that be diabetes, heart disease, dementia, Parkinson disease, fibromyalgia, arthritis, depression & anxiety, …… the list is endless.
Alzheimer's disease (AD) is a neurodegenerative disease, manifesting in clinically observable deficits in memory, thinking, and behavior that disproportionately affects older adults. Susceptibility genes, such as apolipoprotein ε4, have long been associated with an increased risk of AD diagnosis. Studies have shown associations between depression and increased risk of AD development. Furthermore, findings from previous investigations suggest mixed effects in the use of psychotropic medication in older adults. The hypothesis for this study is that antidepressant use modifies the increased hazard of depression or such that a non-significant hazard will result with respect to eventual AD development. Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Research News. Depression does not seem to increase the risk for dementia, but depressive symptoms in later life could be a feature of dementia’s preclinical phase, a 28 year follow-up study in the UK has found.
To read the full article, log in using your NHS OpenAthens details
Befriending is an emotional supportive relationship in which one-to-one companionship is provided on a regular basis by a volunteer. It is commonly and increasingly offered by the voluntary sector for individuals with distressing physical and mental conditions. However, the effectiveness of this intervention on health outcomes is largely unknown. We aim to conduct a systematic review of the benefits of befriending.
Open Access Article
Editorial. : Login at top right hand side of page using your SSSFT NHS Athens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Inflammation of the central nervous system is increasingly regarded as having a role in cognitive disorders such as dementia and depression, but it is not clear how such inflammation relates to other aspects of neuropathology, structural and functional changes in the brain and symptoms (as assessed via clinical and neuropsychological assessment and MRI). This study will explore these pathophysiological mechanisms using positron emission tomography (PET) which allows in vivo imaging of inflammation, amyloid and τ deposition, together with neuropsychological profiling, MRI and peripheral biomarker analysis. Open Access Article
Open access. We studied neuroinflammation in individuals with late-life depression, as a risk factor for dementia, using [11C]PK11195 positron emission tomography (PET).
Nearly a third of people with mild cognitive impairment also have depression, a systematic review and meta-analysis has shown.1
Depression has previously been thought to be common in people with mild cognitive impairment, who show greater decline in cognitive function than expected with normal ageing but not to the level of cognitive loss in dementia. Evidence has shown a link between having depression and increased progression to dementia, so the researchers sought to understand this more fully. To read the full article, log in using your NHS OpenAthens details
Figures released today by NHS Digital provide information on the prevalence of 21 conditions, including heart disease, hypertension, dementia, diabetes, and depression.
To investigate whether depressive symptoms influence global cognitive function in patients with mild cognitive impairment (MCI) and mild Alzheimer's disease (AD) by impeding specific neuropsychological abilities and under what conditions this effect might occur. To read the full article, log in using your NHS OpenAthens details.
Hippocampal volume is commonly decreased in late-life depression. According to the depression-as-late-life-neuropsychiatric-disorder model, lower hippocampal volume in late-life depression is associated with neurodegenerative changes. The purpose of this prospective study was to examine whether lower hippocampal volume in late-life depression is associated with Alzheimer’s disease pathology. Login at top right hand side of page using your SSSFT NHS Athens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Come and visit our first pop-up library at Severn Fields, Shrewsbury 19th July 11.00am-3.00pm. Join the library, borrow and return books, get help finding information and evidence, set up an Athens account, find out what the library can do for you and your team.
A recent study by Mirza et al (2016) published in The Lancet Psychiatry with an accompany editorial (Reppermund, 2016) suggests that older people whose depression symptoms increase over time are at increased risk of developing dementia. According to the authors of this study, they come closer to establishing whether depression is a risk factor for dementia, or vice versa, because they follow a group of people with depressive symptoms over time, rather than assessing them at one time point.
The Hospital Anxiety and Depression Scale (HADS) is a well-validated, self-report measure of both anxiety and depression. It is frequently used with people with dementia. However, its structural validity has never been examined in this population. The current study used confirmatory factor analysis (CFA) to assess this. Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Late-life depressive symptoms have been extensively studied for their relationship with incident dementia, but have been typically assessed at a single timepoint. Such an approach neglects the course of depression, which, given its remitting and relapsing nature, might provide further insights into the complex association of depression with dementia. We therefore repeatedly measured depressive symptoms in a population of adults over a decade to study the subsequent risk of dementia. Please contact the library to receive a copy of this article - http://bit.ly/1Xyazai
A better understanding of the link between depression and dementia is essential, given the rapid growth of the elderly population, with an anticipated doubling of global dementia prevalence every 20 years.1 In the Lancet Psychiatry, the findings presented from the study by Saira Mirza and colleagues2 have brought us one step closer to answering whether depression is a risk factor for dementia or vice versa. They assessed different trajectories of depressive symptoms and their association with subsequent dementia in a large community sample of older adults over the course of 10 years. Please contact the library to receive a copy of this article - http://bit.ly/1Xyazai
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Neuropsychology 30.2 (Feb 2016): 135-142.
Objective: To test the hypothesis that late-life depression is associated with dementia-related pathology. To read the full article, log in using your NHS OpenAthens details
The prevalence of neuropsychiatric symptoms in cognitively impaired nursing home residents is known to be very high, with depression and agitation being the most common symptoms. The possible effects of a 12-week intervention with animal-assisted activities (AAA) in nursing homes were studied. The primary outcomes related to depression, agitation and quality of life (QoL). Login using your SSSFT NHS OpenAthens for full text. SSOTP - request a copy of the article from the library - www.sssft.nhs.uk/library
The aim of this study is to evaluate the effect of a high-intensity functional exercise program on depressive symptoms among older care facility residents with dementia. Login using your SSSFT NHS OpenAthens for full text. SSOTP - request a copy of the article from the library - www.sssft.nhs.uk/library
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Armodafinil From Wikipedia, the free encyclopedia Jump to: navigation, search Armodafinil Systematic (IUPAC) name (-)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide Identifiers CAS number 68693-11-8 ATC code N06BA07 PubChem ? Chemical data Formu
Full-text, online textbook discussing various pharmaceutical, neutraceutical, and lifestyle interventions for enhancing life by facilitating our efforts to reach our fullest potential.