Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical course and outcome. Intravenous immunoglobulin (IVIg) and plasma exchange are proven effective treatments, but the efficacy has been demonstrated mainly on motor improvement in adults with a typical and severe form of GBS. In clinical practice, treatment dilemmas may occur in patients with a relatively mild presentation, variant forms of GBS, or when the onset of weakness was more than 2 weeks ago. Other therapeutic dilemmas may arise in patients who do not improve or even progress after initial treatment. We provide an overview of the current literature about therapeutic options in these situations, and additionally give our personal view that may serve as a basis for therapeutic decision-making. To read the full article, log in using your NHS OpenAthens details.
Zumba Gold® is a dance-based workout developed for older adults that could be beneficial for mobility and well-being in people Parkinson’s (PD). However, to date there is no evidence to support the suitability of this type of exercise in people with PD. To read the full article, log in using your NHS OpenAthens details
While the increased risk of ALS was statistically significant, the overall risk of ALS was still tiny in the exposure group. Of the 58,279 men in the study only 88 died of ALS. With figures as low as these, there is always the risk than any identified link is actually down to chance.
The diagnosis of delirium depends on eliciting its features through mental status examination and informant history. However, there is marked heterogeneity in how these features are assessed, from binary subjective clinical judgement to more comprehensive methods supported by cognitive testing. The aim of this article is to review the neuropsychological research in delirium and suggest future directions in research and clinical practice. Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Editorial. Wahid et al1 describe a boy with cerebral palsy, epilepsy and severe learning difficulties who developed major gastrointestinal problems leading to an extended period of parenteral nutrition (PN) as an inpatient. ....... An important aspect of this case is that after a very long and difficult illness (and against all expectations), gastrointestinal function improved to the extent that weaning from PN was possible. To read the full article, log in using your NHS OpenAthens details.
Surgical treatment can bring seizure remission in people with focal epilepsy but requires careful selection of candidates.
Objectives To determine which preoperative factors are associated with postoperative seizure outcome. To read the full article, log in using your NHS OpenAthens details.
Open access. Conclusion: Except for epilepsy, this research has indicated that the risks of drowning while undertaking aquatic activities are not increased in children with pre-existing medical conditions. Children with pre-existing medical conditions can enjoy aquatic activities when appropriately supervised.
Open access. To examine the baseline prevalence and longitudinal evolution in non-motor symptoms (NMS) in a prospective cohort of, at baseline, patients with de novo Parkinson’s disease (PD) compared with healthy controls (HC).
Blood-brain barrier (BBB) disruption has long been recognised as an important early feature of multiple sclerosis (MS) pathology. Traditionally, this has been seen as a by-product of the myelin-specific immune response. Here, we consider whether vascular changes instead play a central role in disease pathogenesis, rather than representing a secondary effect of neuroinflammation or neurodegeneration. To read the full article, log in using your NHS OpenAthens details.
Open access. Letter. Thank you for this excellent and concise article outlining the complexities involved in neuroleptic malignant syndrome (NMS) in association with atypical antipsychotics.1 It serves as a reminder of how guidelines and diagnostic criteria can, for all their clarity, lead to vexing and imperfect choices.
To develop an instrument (Paediatric Rehabilitation Ingredients Measure [PRISM]) for quantitative estimation of contents of interdisciplinary neurorehabilitation for use in studies of relationships between rehabilitation treatment delivered and severity-adjusted outcomes after acquired brain injury (ABI).. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
To examine the appropriateness and feasibility of cognitive rehabilitation for people with dementias associated with Parkinson's in a pilot randomised controlled study.. To read the full article, log in using your SSSFT NHS OpenAthens details. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Topiramate and carbamazepine appear to be similarly effective in inducing seizure freedom, although analyses including only people with focal (partial)-onset seizures revealed that treatment with carbamazepine resulted in a higher rate of seizure freedom at 12 months and a lower rate of treatment withdrawal.
To examine the baseline prevalence and longitudinal evolution in non-motor symptoms (NMS) in a prospective cohort of, at baseline, patients with de novo Parkinson’s disease (PD) compared with healthy controls (HC). . To read the full article, log in using your NHS OpenAthens details.
Anxiety is a common neuropsychiatric symptom in Parkinson’s disease (PD), yet the neural mechanisms have been scarcely investigated. Disturbances in dopaminergic and serotonergic signalling may play a role in its pathophysiology. . To read the full article, log in using your NHS OpenAthens details.
To investigate whether oral administration of a standardised frankincense extract (SFE) is safe and reduces disease activity in patients with relapsing-remitting multiple sclerosis (RRMS).. To read the full article, log in using your NHS OpenAthens details.
To describe behavioural and psychiatric outcomes of children within 10 years of convulsive status epilepticus (CSE). . Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
As our knowledge of amyotrophic lateral sclerosis (ALS) increases, the salient question has become: Is ALS a single disease or a group of diseases with a final common pathway? Traditionally, ALS has been defined as a rapidly progressive neurodegenerative disorder that affects the large motor neurons of the brain and spinal cord. It presents with an upper or lower motor neuron pattern of weakness but progresses to include all motor neurons (upper and lower, bulbar, cervical, thoracic, and lumbar). Cognition was thought to be affected in only a small subset of patients with ALS. The primary causation theory was that ALS was the result of a single common exposure or genetic mutation, and the primary pathologic finding was simple motor neuron degeneration. Recent studies on the genetics of ALS have changed this view. . Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
In this article, we will discuss the historical development of surgical technique and targets, as well as the technological state-of-the-art of conventional and incisionless interventions for tremor due to Parkinson’s disease, essential and dystonic tremor and tremor related to multiple sclerosis (MS) and midbrain lesions.. To read the full article, log in using your NHS OpenAthens details.
This systematic review critically assesses structural and functional neuroimaging studies of psychosis of epilepsy (POE). We integrate findings from 18 studies of adults with POE to examine the prevailing view that there is a specific relationship between temporal lobe epilepsy (TLE) and POE, and that mesial temporal lobe pathology is a biomarker for POE.. To read the full article, log in using your NHS OpenAthens details.