This is a valuable study that furthers our understanding of the brain changes that may occur before any symptoms of Parkinson's disease develop. However, before concluding that measuring serotonin activity is a way of detecting who's likely to develop Parkinson's, it's important to set this finding in the right context.
For the vast majority of people who develop Parkinson's, the cause is unclear. Families with gene mutations that place them at strong hereditary risk of the condition are very rare.
Many people with parkinsonism require care as the disease progresses with much provided unpaid by family and friends. Caring for someone can have a negative impact on physical and psychosocial wellbeing. Caregiver burden can impact ability to continue this role, which can precipitate hospitalisation or institutionalisation of the recipient. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This commentary is on the original article by Whitney et al. To view this paper visit https://doi.org/10.1111/dmcn.14175.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Language is a key source of cross-cultural variability, which may have both subtle and major effects on neurocognition. However, this issue has been largely overlooked in two flourishing lines of research assessing the relationship between language-related neural systems and dementia. This paper assesses the limitations of the evidence on (i) the neuroprotective effects of bilingualism in Alzheimer's disease and (ii) specific language deficits as markers of Parkinson's disease. Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
The number of people affected by Parkinson’s disease (PD) is increasing in the United Kingdom driven by population ageing. The treatment of the disease is complex, resource intensive and currently there is no known cure to PD. The National Health Service (NHS), the public organisation delivering healthcare in the UK, is under financial pressures. There is a need to find innovative ways to improve the operational and financial performance of treating PD patients. The use of community services is a new and promising way of providing treatment and care to PD patients at reduced cost than hospital care. The aim of this study is to evaluate the potential operational and financial benefits, which could be achieved through increased integration of community services in the delivery of treatment and care to PD patients in the UK without compromising care quality.
A disturbed circadian rhythm seems to be a causal factor in the occurrence of depressive disorders in patients with Parkinson’s disease (PD). The circadian rhythm can be restored with light. Therefore, Bright Light Therapy (BLT) might be a new treatment option for depression in PD patients.
What structures of the circadian system are impaired in Parkinson disease, multiple system atrophy, and progressive supranuclear palsy? . Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Technological improvements in the 1990s and 2000s first permitted the recording of large quantities of digital electroencephalography (EEG) data for subsequent analysis and review. These continuous EEG (cEEG) recordings allowed for improved characterization of electrical patterns that were abnormal but not clearly seizures (eg, on the ictal-interictal continuum), and they showed that more patients were having electrographic seizures than were exhibiting clinical features of seizure activity. . Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Objective: To evaluate fidelity, treatment enactment and the experiences of an occupational therapy intervention in Parkinson’s disease, to identify factors that affect intervention delivery and benefits. To read the full article, log in using your NHS OpenAthens details
Objective: To explore the factors perceived to affect rehabilitation assessment and referral practices for patients with stroke. To read the full article, log in using your SSSFT NHS OpenAthens details
Complementary non-pharmacological approaches, such as aerobic exercise, have been evaluated for over two decades. The heterogeneity of the interventions and outcomes used hinders the interpretation of the effect of exercise in PD.1 Several systematic reviews and meta-analyses have pooled the results, but their conclusions depend greatly on the diversity of the included exercise modalities. .....To read the full article, log in using your NHS OpenAthens details.
Parkinson’s disease (PD) is a complex neurodegenerative disorder characterised by disabling motor and non-motor signs. Current medical therapies can partially alleviate these symptoms, but are also accompanied by dose-limiting side effects. Moreover, their therapeutic window narrows with disease progression, leaving the patient with increasing disability. Complementary non-pharmacological approaches, such as aerobic exercise, have been evaluated for over two decades. The heterogeneity of the interventions and outcomes used hinders the interpretation of the effect of exercise in PD.1 Several systematic reviews and meta-analyses have pooled the results, but their conclusions depend greatly on the diversity of the included exercise modalities. Nevertheless, a beneficial effect of exercise on motor symptoms of PD as well as a general health benefit (physical fitness) seems likely from these studies.. To read the full article, log in using your NHS OpenAthens details.
Resective surgery is a safe and effective treatment of drug-resistant epilepsy. If surgery has failed reoperation after careful re-evaluation may be a reasonable option. This study was to summarise the risks and benefits of reoperation in patients with epilepsy. To read the full article, log in using your NHS OpenAthens details
To investigate whether oral administration of a standardised frankincense extract (SFE) is safe and reduces disease activity in patients with relapsing-remitting multiple sclerosis (RRMS).. To read the full article, log in using your NHS OpenAthens details.
To examine sex and age distributions in neuroleptic malignant syndrome (NMS) patients based on a systematic literature review. Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Open access. Functional cognitive disorder (FCD) describes cognitive dysfunction in the absence of an organic cause. It is increasingly prevalent in healthcare settings yet its key neuropsychological features have not been reported in large patient cohorts. We hypothesised that cognitive profiles in fibromyalgia (FM), chronic fatigue syndrome (CFS) and functional neurological disorders (FNDs) would provide a template for characterising FCD.
Open access. Functional cognitive disorder (FCD) describes cognitive dysfunction in the absence of an organic cause. It is increasingly prevalent in healthcare settings yet its key neuropsychological features have not been reported in large patient cohorts. We hypothesised that cognitive profiles in fibromyalgia (FM), chronic fatigue syndrome (CFS) and functional neurological disorders (FNDs) would provide a template for characterising FCD.
To investigate clinical and radiological outcomes of women with relapsing-remitting multiple sclerosis (RRMS) undergoing abortion. . To read the full article, log in using your NHS OpenAthens details.
Depending on patient age at onset, absence epilepsy is subdivided into childhood and juvenile forms. Absence seizures can occur several times per day (pyknoleptic course) or less frequently than daily (non-pyknoleptic course). Seizures typically terminate before adulthood, but a quarter of patients need ongoing treatment beyond adolescence. Little is known about their long-term seizure and psychosocial outcome.. To read the full article, log in using your NHS OpenAthens details.
Depending on patient age at onset, absence epilepsy is subdivided into childhood and juvenile forms. Absence seizures can occur several times per day (pyknoleptic course) or less frequently than daily (non-pyknoleptic course). Seizures typically terminate before adulthood, but a quarter of patients need ongoing treatment beyond adolescence. Little is known about their long-term seizure and psychosocial outcome.. To read the full article, log in using your NHS OpenAthens details.
Open access. Deep brain stimulation (DBS) for Parkinson's disease (PD) is currently limited by costs, partial efficacy and surgical and stimulation-related side effects. This has motivated the development of adaptive DBS (aDBS) whereby stimulation is automatically adjusted according to a neurophysiological biomarker of clinical state, such as β oscillatory activity (12–30 Hz). aDBS has been studied in parkinsonian primates and patients and has been reported to be more energy efficient and effective in alleviating motor symptoms than conventional DBS (cDBS) at matched amplitudes.1 ,2
However, these studies have not considered whether side effects can also be avoided with clinically effective stimulation. In PD, it is well recognised that a significant proportion of patients develop speech deterioration following DBS of the subthalamic nucleus (STN), which may be reversible.3
Here we test bilateral stimulation, optimising parameters for aDBS, and evaluate speech intelligibility. We hypothesised that acute aDBS would be more effective and more efficient than cDBS at matched stimulation parameters while causing less speech impairment.
To characterize the adaptive behavior profile of children with neurofibromatosis type 1 (NF1) and determine its relationship to neuropsychological functioning and non‐neoplastic T2‐weighted hyperintense brain lesions on brain magnetic resonance imaging (MRI).. To read the full article, log in using your MPFT NHS OpenAthens details.
Sexuality and intimacy are poorly researched in both people living with Parkinson's and in older people. Triggers for discussion usually centre on sexual dysfunction and hypersexuality in relation to Parkinson's. However, there are many more factors that impact on physical and emotional connectedness. Despite highlighting this unmet need there are limited tools or comprehensive assessments available to help improve quality of life. To read the full article, log in using your MPFT NHS OpenAthens details.
This systematic review aims to assess the safety profile of oxcarbazepine during pregnancy. It will help healthcare providers and guideline developers regarding the treatment of epilepsy and other neurological disorders during pregnancy. To read the full article, choose “Institutional Login” and search for “Midlands Partnership”.
Editorial commentary: Lacey and colleagues take the innovative approach of using linkage of routine-collected health and national education data to carry out a matched case–control study to assess educational attainment of children born to mothers with epilepsy1. Their main finding was in utero exposure to antiepileptic drugs (AED) in combination, or sodium valproate alone, is associated with a significant decrease in attainment in national educational tests for 7-year-old children compared with both the matched control group and the all-Wales national average. Arguably, at first glance, this may not seem like news per se but there are several points that make it highly noteworthy........ To read the full article, log in using your NHS OpenAthens details.
This study sought to: (1) determine what is known about age at referral for diagnosis and rehabilitation services for children suspected of having cerebral palsy (CP); and (2) identify factors associated with earlier referral.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Dementia with Lewy bodies (DLB) is characterised by neuroleptic hypersensitivity. It is unclear, however, whether the neuroleptic hypersensitivity implies an increased incidence of neuroleptic malignant syndrome (NMS) or of akinetic crisis (AC), which are expressions of the same possibly lethal clinical event, and whether AC in DLB can appear independently of neuroleptic treatment. In our prospective study, we assessed the incidence of AC in a cohort of DLB as compared with that in patients with Parkinson disease (PD). To read the full article, log in using your NHS OpenAthens details
Dementia with Lewy bodies (DLB) is characterised by neuroleptic hypersensitivity. It is unclear, however, whether the neuroleptic hypersensitivity implies an increased incidence of neuroleptic malignant syndrome (NMS) or of akinetic crisis (AC), which are expressions of the same possibly lethal clinical event, and whether AC in DLB can appear independently of neuroleptic treatment. In our prospective study, we assessed the incidence of AC in a cohort of DLB as compared with that in patients with Parkinson disease (PD). To read the full article, log in using your NHS OpenAthens details.
The aim of this study was to evaluate the feasibility of implementing the Parkinson Wellness Recovery Moves intervention into the treatment of patients with Parkinson's disease, within an inpatient rehabilitation hospital. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Question Is uncomplicated childhood-onset epilepsy associated with increased brain amyloid accumulation?
Findings In this population-based case-control study of Finnish adults who had childhood epilepsy and were followed up prospectively for more than 50 years from their disease onset and a group of matched controls, individuals with childhood-onset epilepsy, and particularly APOE ε4 carriers, had an increased brain amyloid load as measured with positron emission tomography at late middle age.
Meaning Childhood-onset epilepsy is linked with a biomarker that might be associated with accelerated brain aging and can be considered as a neurobiological predisposition to later-life cognitive disorders. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
We performed a meta-analysis to synthesise current evidence on amyloid-positron emission tomography (PET) burden and presumed preferential occipital distribution in sporadic cerebral amyloid angiopathy (CAA).. To read the full article, log in using your NHS OpenAthens details.
BPS Blog post. Deep brain stimulation is a medical procedure that involves implanting electrodes permanently into the brain and using them to alter the functioning of specific neural networks. A battery inserted subcutaneously in the chest provides the device with power. One application of the technology is as a treatment for Parkinson’s Disease, a neurodegenerative condition that causes tremors and difficulties moving. While the treatment can bring about an impressive alleviation of symptoms, research suggests that Parkinson’s patients often struggle to adjust psychologically. Now a case study published in the British Journal of Health Psychology has provided some of the first insights into what it’s like for a patient to contemplate undergoing surgery for deep brain stimulation, and then to adjust in the immediate aftermath.
Editorial commentary. Over the last 30 years, disease-modifying drugs (DMDs) that target the immune system either by lymphocytoreduction or by modulating lymphocyte function have become available to treat multiple sclerosis. While all control the episodic acute inflammation of the central nervous system, disease activity ultimately breaks through inevitably resulting in progressive disabilities. It is against this background that the role of autologous haematopoietic stem cell transplantation (aHSCT) has been examined.. To read the full article, log in using your NHS OpenAthens details.
Haematopoietic stem cell transplantation is able to control multiple sclerosis in patients who have failed modern disease modifying drugs
Over the last 30 years, disease-modifying drugs (DMDs) that target the immune system either by lymphocytoreduction or by modulating lymphocyte function have become available to treat multiple sclerosis. While all control the episodic acute inflammation of the central nervous system, disease activity ultimately breaks through inevitably resulting in progressive disabilities. It is against this background that the role of autologous haematopoietic stem cell transplantation (aHSCT) has been examined.. To read the full article, log in using your NHS OpenAthens details.
Advancements in the management of FND emphasise a ‘rule-in’ diagnosis and roles for cognitive behavioural therapy (CBT)1 and physical therapy (PT).2 Neuroimaging studies have also started delineating the neuropathophysiology of FND.3 In the same cohort as this present study, we previously identified that impaired mental health and increased trait anxiety correlated with individual differences in amygdalar volume in patients with FND, while diminished physical functioning was associated with reduced anterior insular volume.4 In FND, the magnitude of adverse life event burden also correlated with decreased insular and hippocampal volumes.5. To read the full article, log in using your NHS OpenAthens details.
Advancements in the management of FND emphasise a ‘rule-in’ diagnosis and roles for cognitive behavioural therapy (CBT)1 and physical therapy (PT).2 Neuroimaging studies have also started delineating the neuropathophysiology of FND.3 In the same cohort as this present study, we previously identified that impaired mental health and increased trait anxiety correlated with individual differences in amygdalar volume in patients with FND, while diminished physical functioning was associated with reduced anterior insular volume.4 In FND, the magnitude of adverse life event burden also correlated with decreased insular and hippocampal volumes.5. To read the full article, log in using your NHS OpenAthens details.
Open access. Depression, which is common following acquired brain injury (ABI), has been shown to predict cognitive impairment, rehabilitation outcome, and quality of life. Whilst many studies have examined links between depression and cognitive–affective processing in the non‐ABI population, their applicability to this important clinical group, where cognitive difficulties can be marked, remains unknown. Here, we investigated biases in prospective cognition, which is known to be disrupted in (non‐ABI) depression yet important for well‐being.
Open access. Epilepsy is a serious condition which can profoundly affect an individual’s life. While there is some evidence to suggest an association between antidepressant use and epilepsy and seizures it is conflicting and not conclusive. Antidepressant prescribing is rising in the UK so it is important to quantify absolute risks with individual antidepressants to enable shared decision making with patients. In this study we assess and quantify the association between antidepressant treatment and the risk of epilepsy and seizures in a large cohort of patients diagnosed with depression aged between 20 and 64 years.
To compare the time to withdrawal of allocated treatment, remission and first seizure of 10 AEDs currently used as monotherapy in children and adults with partial onset seizures (simple partial, complex partial or secondary generalised) or generalised tonic-clonic seizures with or without other generalised seizure types (absence, myoclonus).
To investigate potential harm and benefits of antiepileptic drugs (AED) given prophylactically to prevent de novo brain tumour-related epilepsy after craniotomy.. To read the full article, log in using your NHS OpenAthens details.
To investigate potential harm and benefits of antiepileptic drugs (AED) given prophylactically to prevent de novo brain tumour-related epilepsy after craniotomy.. To read the full article, log in using your NHS OpenAthens details.
Editorial. The use of antiepileptic drugs (AED) is common in women of childbearing age. One study1 reported that prenatal AED exposure occurred in 2.19% of all pregnancies in the United States. In the past decade, findings have highlighted that it is no longer sufficient to only consider the association between first-trimester exposure and the risk for structural teratogenicity, because prenatal AED exposure throughout the entire pregnancy can have long-term negative consequences on neurodevelopment. The published studies are limited in scope but have consistently reported that valproate prenatal exposure is associated with lower scores on neuropsychometric batteries during early childhood,2,3 while prenatal exposure to carbamazepine and lamotrigine monotherapies is associated with relatively normal scores. Risks associated with most other AEDs have not been adequately studied, to my knowledge.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Letter. Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Among patients with inflammatory bowel disease, what is the incidence of Parkinson disease, and does earlier exposure to anti–tumor necrosis factor therapy mitigate their risk of Parkinson disease?. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Apathy is a prominent and disabling symptom in Parkinson's disease (PD) and is a multidimensional behaviour, but which dimensions are specifically affected is unclear. Therefore, the aim of this preliminary study was to determine the psychometric properties of the Dimensional Apathy Scale (DAS) and explore the multidimensional profile of apathy in PD patients. Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
This item concludes that the delivery of health services for children and young people with neurodisability should encompass the broad needs of the family as well as meeting the clinical needs of the CYP. Open access article - no login required.
Tuberous sclerosis complex (TSC) is a complex multisystem genetic disorder. Approximately 84% of people with TSC have epilepsy. However, there is little literature available regarding families' experiences with TSC and seizure management. Therefore, the aim of the current study was to explore families' positive and negative experiences, and attitudes towards TSC, epilepsy and medical management of seizures.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Rehabilitation Psychology (Mar 21, 2019). DOI:10.1037/rep0000273
Objectives: Pain has been identified as a highly prevalent and common correlate of physical and emotional dysfunction among persons with multiple sclerosis (PwMS). Yet, it remains unknown how PwMS experience the intrusiveness of pain relative to other challenges associated with living with MS. This study aimed to determine the extent to which PwMS experience pain as a particularly intrusive problem among the totality of their experience of MS-related challenges and to examine how cognitive and affective factors, including resiliency, are associated with PwMS’s pain-related illness intrusiveness.. To read the full article, log in using your NHS OpenAthens details.