Extracellular vesicles (EVs) carry protein cargo inherited from originating cells and may be useful for defining differences in key proteins related to hepatic drug metabolism and the treatment of metabolic-associated fatty liver disease (MAFLD). We sought to quantify these proteins in liver-derived EVs and establish the profile relative to paired tissue. Open access article - no login required
A cross-disciplinary symposium was held in December 2023, whereby experts from different scientific disciplines engaged in a high-level discussion on the opportunities and challenges of mathematical models in different fields, possible future developments and decision making. Open access article - no login required
This study aimed to describe the use of recommendations as a guide for healthcare providers to support patients experiencing medication self-management problems and to evaluate their feasibility, user-friendliness and usefulness. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
To characterize pharmacokinetic and pharmacodynamic profiles of nedosiran in patients with primary hyperoxaluria type 1 (PH1), identify influential covariates and confirm therapeutic doses. Open access article - no login required
In this study, we leveraged modelling and simulation approaches to predict and compare the free IgE reduction and forced expiratory volume in 1 second (FEV1) improvement with omalizumab dosing based on the US and EU asthma dosing tables. Open access article - no login required
In this systematic review, we report on the effects of diuretic deprescribing compared to continued diuretic use. Open access article - no login required
This study assessed mitiperstat pharmacokinetics, safety and tolerability in participants with severe renal impairment and normal renal function, to inform inclusion of participants with estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m2 in phase 3. Open access article - no login required
This study aimed to develop a population pharmacokinetic (popPK) model to describe the pharmacokinetics of sertraline during the perinatal period and explain interindividual variability. Open access article - no login required
While medication adherence (MA) is a key prerequisite for achieving optimal clinical and economic outcomes, nonadherence is highly prevalent. Assessing how healthcare professionals (HCPs) in Europe manage MA, focusing on measurement, reporting and interventions, is the subject of this study. Open access article - no login required
Dried blood volumetric absorptive microsamples (VAMS) may facilitate home-based sampling to enhance therapeutic drug monitoring after transplantation. This study aimed to clinically validate a liquid chromatography–tandem mass spectrometry assay using 2 VAMS devices with different sampling locations (Tasso-M20 for the upper arm and Mitra for the finger). Patient preferences were also evaluated. Open access article - no login required
Transgender persons face a greater burden of HIV compared to cisgender counterparts. Concerns around drug–drug interactions (DDIs) have been cited as reasons for lower engagement in HIV care and lower pre-exposure prophylaxis (PrEP) uptake among transgender populations. It is therefore imperative for hormone therapy, PrEP and antiretroviral therapy providers to understand the DDI potential between these therapies. Open access article - no login required
This study investigated the safety and effects on regional cerebral blood flow (rCBF) of the oral, brain-penetrant β2-AR agonist, clenbuterol, in healthy volunteers (HV) and patients with mild cognitive impairment (MCI) or Parkinson's disease (PD). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The aims of this study were to develop a population pharmacokinetic (PK) model for risperidone ISM® and to investigate the relationships between active moiety exposure, as described by apparent clearance (CL40), and several covariates using all data from five clinical studies. Open access article - no login required
This study aimed to determine whether the integration of a clozapine clinic within an early intervention for psychosis service resulted in a change in the rate and time to initiation of clozapine, the number of trials of different antipsychotic medications prior to clozapine, community initiation and discontinuation rates. Open access article - no login required.
The aims of this study are: (i) to validate the predictive performance of existing IFX PopPK models using a cohort of children with IBD; and (ii) to perform a Bayesian estimation of the most suitable model to predict the next IFX concentrations. Open access article - no login required
We aimed to characterize the cardiovascular AEs of BTKIs reported in the US Food and Drug Administration (FDA) Adverse Event Reporting System, and to compare the cardiovascular risks of BTKIs. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
In this article, we propose a strategy of patient-controlled, home-based, self-TDM of the immunosuppressant tacrolimus after transplantation. Open access article - no login required.
The aims of this study were to measure the prevalence of polypharmacy and describe the prescribing of selected medications known for overuse in older people with polypharmacy in primary care. Open access article - no login required.
Community pharmacists’ knowledge deficits about frailty must be addressed and their communication skills enhanced so they may confidently initiate conversations about frailty and medicines use with older adults.
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This study uses habit formation models to investigate the dynamic interplay between psychosis, clozapine dose and obsessive–compulsive symptoms (OCS). Open access article - no login required.
We investigated the extent to which trials of drugs and biologics represented transgender people across therapeutic areas on ClinicalTrials... Open access article - no login required
In this controlled pilot, we examined the safety (i.e., side-effect profile) of lithium in a sample of young people identified at ultra-high risk (UHR) for psychosis. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This review explores the possible role of psychedelics in the management of chronic pain and opioid use disorder. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
In this narrative review we describe innovative methods in pharmacovigilance studies of medicines in older people that leverage the increasing availability of digital health technologies, electronic health records and real-world health data to identify and quantify medication related harms in older people. Open access article - no login required.
This article summarizes existing national-level approaches to assessing prescribing competence, provides a systematic review of current literature, indicates the frequency of various methodologies, and make recommendations to promote and extend existing practice. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study aimed to assess the frequency of dosing inconsistencies in prescription data and the effect of four dosing assumption strategies on adherence estimates for antipsychotic treatment. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study evaluates the time course of pain and craving and objective experience of pain as a function of the last methadone dose. Preliminary findings highlight the potential for increased risks after even a short delay in receiving a methadone dose. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Despite efforts, in-hospital prescribing errors and related harm still occur, necessitating an innovative approach. We therefore propose a novel approach, in-hospital pharmacotherapeutic stewardship (IPS). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The objective of this meta-analysis was to determine whether maternal exposure to folate antagonists is associated with increased rates of congenital heart disease in offspring. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The aim of this study was to systematically review whether concurrent treatment with an SSRI and low-dose ASA increases the risk of bleeding compared with treatment with an SSRI alone or ASA alone. Open access article - no login required.
This editorial looks at therapeutic drugs for gout. Although various therapies are available for gout treatment, the target of healing gout is often not achieved. Gout treatment often requires long-term medication, drug safety requires special attention. Open access article - no login required.
The aim of this study was to assess the correlation between adherence assessed with a Medication Event Monitoring System (MEMS) versus pill count, MTX-polyglutamate (PG) concentration and Compliance-Questionnaire-Rheumatology (CQR) in patients with established rheumatoid arthritis. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Our study investigated the association between patients’ willingness to have medications deprescribed and medication adherence. This longitudinal sub-study took place in Swiss primary care settings. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The aim of this study was to analyse sex-specific differences in ADR-drug combinations which required hospitalisation based on two different datasets. Open access article - no login required.
This review serves as an introduction to AI for the clinical pharmacologist, highlighting current applications, aspects of model development and issues surrounding evaluation and deployment. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The present work aims to provide a descriptive and comprehensive overview of the currently utilized PIs documentation and classification tools contributing to increased evidence systematization. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The United Kingdom (UK) Prescribing Safety Assessment (PSA) is a 2-hour online assessment of prescribing competence. This study describes the academic characteristics and performance of the assessment; longitudinal performance of candidates and schools; stakeholder feedback; and surrogate markers of prescribing safety in UK healthcare practice. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Why you should read this article:
To recognise how comorbidities in older people, including frailty, increase the risk of polypharmacy.
To increase your awareness of the burden of polypharmacy for patients and healthcare services.
To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The aim of this umbrella review was to identify tools and guidelines to aid the deprescribing process of potentially inappropriate medications (PIM), evaluate development and validation methods, and describe evidence levels for medication inclusion. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This article evaluates the performance of chat generative pre-trained transformer (ChatGPT) in key domains of clinical pharmacy practice, including prescription review, patient medication education, adverse drug reaction (ADR) recognition, ADR causality assessment, and drug counselling. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This systematic literature review investigated how often the unintended impact of regulatory interventions was considered in publications of studies investigating pharmacovigilance regulatory interventions in Europe. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study suggests that ADEs post hospital discharge can be linked with identifiable medication clusters. This information may help clinicians and researchers better understand patient populations that are more or less likely to benefit from peri-hospital discharge interventions aimed at reducing ADEs. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Old age and glucocorticoid (GC) use increase the susceptibility to infection in patients with rheumatoid arthritis (RA). Accordingly, we investigated whether GC discontinuation reduces the incidence of infection in older adults with RA and analyzed factors associated with GC discontinuation. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Deprescribing aims to address the problem of medication overuse in older adults. We aimed to describe the categories of trials included in recent systematic reviews, and to make recommendations for future research. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Aripiprazole is recommended for routine use in schizophrenia patients. However, the biological mechanism for the adverse drug reactions (ADRs) among schizophrenia patients with the antipsychotic drug aripiprazole is far from clear. To explore the potential genetic factors that may cause movement-related adverse antipsychotic effects in patients, we conducted an association analysis between movement-related ADRs and SNPs in schizophrenia patients receiving aripiprazole monotherapy.
To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
We describe the approach to biosimilar adoption at a single hospital and compare its efficiency against the English average. The approach we describe resulted in a faster and more complete switch to biosimilars, which saved an additional £380,000 on drug costs in 2021/22. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Results of this study suggest that people aged≥85 living at home with disability, visual and/or cognitive impairment will have difficulty taking their medications, regardless of how many they are prescribed. Therefore, healthcare professionals should routinely ask about, assess and address problems that these patient groups may have with taking their medicines, independent of the number of drugs taken. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This article investigates the potential association of chronic use of omeprazole with the occurrence of osteoporotic fractures (OF) in community-dwelling elderly subjects. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Drug shortages make it difficult or impossible to meet the therapeutic needs of individual patients or populations. Here we discuss causes and possible solutions. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
In the first part of this two-part review we discuss definitions of drug shortages and so-called stock-outs, which are localized shortages, and the harms that they can cause. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.