Introduction This is the manual for the Sage mathematical software system. Sage is free open source math software that supports research and teaching in algebra, geometry, number theory, cryptography, and related areas. Both the Sage development model an
Hal Varian, What econometrics can learn from machine learning and vice versa. http://www.stanford.edu/class/ee380/winter-schedule-20142015.html http://www.stanford.edu/class/ee380/Abstracts/140129.html http://ee380.stanford.edu/cgi-bin/videologger.php?target=140129-ee380-300.asx 140129-ee380-500.wmv 140129-slides-Machine-Learning-and-Econometrics.pdf
Dopamine transmission is involved in reward processing and motor control, and its impairment plays a central role in numerous neurological disorders. Despite its strong pathophysiological relevance, the molecular and structural organization of the dopaminergic synapse remains to be established. Here, we used targeted labelling and fluorescence activated sorting to purify striatal dopaminergic synaptosomes. We provide the proteome of dopaminergic synapses with 57 proteins specifically enriched. Beyond canonical markers of dopamine neurotransmission such as dopamine biosynthetic enzymes and cognate receptors, we validated 6 proteins not previously described as enriched. Moreover, our data reveal the adhesion of dopaminergic synapses to glutamatergic, GABAergic or cholinergic synapses in structures we named “dopamine hub synapses”. At glutamatergic synapses, pre- and postsynaptic markers are significantly increased upon association with dopamine synapses. Dopamine hub synapses may thus support local dopaminergic signalling, complementing volume transmission thought to be the major mechanism by which monoamines modulate network activity. The neurotransmitter dopamine is an important regulator of brain function. Here the authors describe “dopamine hub synapses”, where dopamine transmission may act in synergy with other neurotransmitters.
accessing_zotero_data_using_an_sqlite_client Whenever possible, people writing utilities that access Zotero data should use the Zotero data API from within Firefox, as it provides both a consistent interface to the data regardless of the underlying str
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