The cellular and extracellular matrix accumulations that comprise the lesions of atherosclerosis are driven by local release of cytokines at sites of predilection for lesion formation, and by the specific attraction and activation of cells expressing rece
Exposure to secondhand smoke leads to inflammation and oxidation, representing another pathophysiologic mechanism for the development of atherosclerosis.
Researchers say circulating mononuclear cells (the largest type of white blood cell) and lymphocytes, exist in a proinflammatory state in obese persons known to be at increased risk of developing heart disease, diabetes, or both.
Accumulating evidence supports the hypothesis that chronic low-grade inflammation and activation of the innate immune system are closely involved in the pathogenesis of the type 2 diabetes.
In conclusion, the daily supplementary intake of 500 mg green tea polyphenols did not have clear effects on blood glucose level, Hb Alc level, insulin resistance or inflammation markers. The positive correlation between the level of polyphenol intake and
Statins have nonlipid mechanisms that modify endothelial function, inflammatory responses, plaque stability, and thrombus formation. Benefits extend to patients with normal lipid levels due to statins' pleiotropic effects.
Anti-Inflammatory Effects of Pioglitazone and/or Simvastatin in High Cardiovascular Risk Patients With Elevated High Sensitivity C-Reactive Protein The PIOSTAT Study
While the cause of statin-associated myopathy is controversial, a central role for coenzyme Q10 (CoQ10 or ubiquinone) is slowly gaining acceptance. Statins have been shown to create an acquired CoQ10 deficiency.
ntake of Fish Oil, Oleic Acid, Folic Acid, and Vitamins B-6 and E for 1 Year Decreases Plasma C-Reactive Protein and Reduces Coronary Heart Disease Risk Factors in Male Patients in a Cardiac Rehabilitation Program1
Evidence emerged from studies in mice that hepcidin, a small peptide hormone exclusively produced in the liver in response to inflammation, could completely or nearly completely shut down normal iron hemostasis.
Journal of Nutrition, Vol 128 No 2 February 1998 Muredach P Reilly, John A Lawson, and Garret A FitzGerald Center for Experimental Therapeutics, University of Pennsylvania School of Medicine Philadelphia, PA 19104
The same cytokine may have different effects in different circumstances. (This is called ' pleotropy '). See below chart for key functions of significant cytokines.
PERSISTENT LOW-GRADE INFLAMMATION, as indicated by higher circulating levels of inflammatory mediators such as C-reactive protein, interleukin-6 and tumour necrosis factor-, is a strong risk factor for several chronic diseases. There are data indicating t
Mitogen-activated protein kinase p38 is a serin/threonine kinase originally isolated from lipopolysaccharide stimulated monocytes. There are 4 isoforms; p38-a activation has been most widely studied for inflammation...
We describe how innate and adaptive immune cascades trigger the release of cytokines and chemokines, resulting in the initiation and progression of atherosclerosis. We discuss how cytokines have direct and indirect effects on myocardial function.
Atherosclerosis is the predominant underlying pathology of cardiovascular disease...atherosclerotic lesions are characterized by abundance of immune cells and their effector molecules, eventually leading to unstable angina, myocardial infarction, or strok
Inflammation: (Latin, inflammatio, to set on fire) is the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants.
Central neuropeptides, including corticotropin releasing factor and perhaps substance P as well, initiate a systemic stress mobilization response by activating the sympathetic nervous system, hypothalamic pituitary axis, and the renin angiotensin system,
Underlying the body’s healing response is a process by which tissues inflame. Chronic inflammation, if left unchecked, can devastate the body’s tissues, especially in the vascular and nervous systems. Numerous natural products help control the inflamm
This study suggests, but can't prove, that omega-3 fats reduce levels of inflammation. But it offers one more reason to eat seafood a few times a week without worrying that the soy oil in your salad dressing will cancel out the seafood's benefits.
Elevated levels of c-reactive protein (CRP) are known to be associated with insulin resistance and metabolic syndrome in adults. A substantial prevalence of hyperinsulinaemia and elevated CRP levels have been shown in Indian young adults.
Research on function & role of micronutrients, phytochemicals, and antioxidants in chronic diseases (cardiovascular, metabolic, cancer, aging, neurodegenerative).
scientists reported that a person's risk of a heart attack is doubled if he or she produces a particular version of FLAP, known more technically as 5-lipoxygenase activating protein. A troublesome variant of this protein boosts production of the inflammat
Doctors are trying to understand, for example, why some individuals suffer heart attacks even though they do not have major heart blockages - and inflammation may be the answer. In fact, many chronic cardiovascular diseases suffered by millions of America
Today we're going to discuss the anemia of inflammation -- starting with its mechanisms, then looking at a fairly new genetic link between inflammation and anemia, and including how we can apply all of this to our patients.
The roles and functions of cytokines are confusing and still being sorted out. Over three dozen have been identified with more being discovered each day.
Statins exert their pleiotropic effects, in part, by improving endothelial function via up-regulation of endothelial nitric oxide synthase enzyme activity.
