jepcastel > EndpointDetermination

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1A concise display of multiple end points for benefit-risk assessment.
B. Levitan. Clinical pharmacology and therapeutics, 89 (1): 56-9 (Januar 2011)5920<m:linebreak></m:linebreak>JID: 0372741; 0 (Antipsychotic Agents); 2010/11/24 aheadofprint; ppublish;<m:linebreak></m:linebreak>Presentació de dades; Gràfics; Relació benefici/risc.
vor 2 Jahren von @jepcastel
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RiskAssessment
Humans
Clinical
Schizophrenia
AntipsychoticAgents
Pharmacology
DataInterpretation
Computer-Assisted
AntipsychoticAgents:adverseeffects
DecisionMaking
AntipsychoticAgents:therapeuticuse
PatientDropouts:statistics&numericaldata
Clinical:methods
Schizophrenia:drugtherapy
ComputerGraphics
PatientDropouts
Statistical
RiskAssessment:methods
Software
StatisticsasTopic
EndpointDetermination
Clinical:trends
RiskAssessmentHumansClinicalSchizophreniaAntipsychoticAgentsPharmacologyDataInterpretationComputer-AssistedAntipsychoticAgents:adverseeffectsDecisionMakingAntipsychoticAgents:therapeuticusePatientDropouts:statistics&numericaldataClinical:methodsSchizophrenia:drugtherapyComputerGraphicsPatientDropoutsStatisticalRiskAssessment:methodsSoftwareStatisticsasTopicEndpointDeterminationClinical:trends
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1An introduction to competing risks analysis.
M. Pintilie. Revista española de cardiología, 64 (7): 599-605 (Juli 2011)6208<m:linebreak></m:linebreak>CI: Copyright (c) 2011; JID: 0404277; 2011/01/18 received; 2011/03/23 accepted; 2011/05/31 aheadofprint; ppublish;<m:linebreak></m:linebreak>Anàlisi de supervivència; Competing risks; Introductori.
vor 2 Jahren von @jepcastel
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RiskAssessment
Humans
Probability
HeartDiseases:epidemiology
ReproducibilityofResults
Algorithms
Statistical
Models
RiskAssessment:statistics&numericaldata
HeartDiseases
Software
HeartDiseases:diagnosis
TreatmentOutcome
EndpointDetermination
Kaplan-MeierEstimate
RiskAssessmentHumansProbabilityHeartDiseases:epidemiologyReproducibilityofResultsAlgorithmsStatisticalModelsRiskAssessment:statistics&numericaldataHeartDiseasesSoftwareHeartDiseases:diagnosisTreatmentOutcomeEndpointDeterminationKaplan-MeierEstimate
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1Assessment of futility in clinical trials.
S. Snapinn, M. Chen, Q. Jiang, und T. Koutsoukos. Pharmaceutical statistics, 5 (4): 273-81 (2006)7401<m:linebreak></m:linebreak>LR: 20071115; JID: 101201192; ppublish;<m:linebreak></m:linebreak>Mesures de contrast; RCT.
vor 2 Jahren von @jepcastel
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EvaluationStudiesasTopic
RCT
ResearchDesign
Humans
StochasticProcesses
Probability
MyocardialInfarction
DataInterpretation
Ethics
TimeFactors
MyocardialInfarction:drugtherapy
SampleSize
Statistical
Models
MulticenterStudiesasTopic
ClinicalTrialsasTopic
Medical
EndpointDetermination
ClinicalTrialsasTopic:methods
EvaluationStudiesasTopicRCTResearchDesignHumansStochasticProcessesProbabilityMyocardialInfarctionDataInterpretationEthicsTimeFactorsMyocardialInfarction:drugtherapySampleSizeStatisticalModelsMulticenterStudiesasTopicClinicalTrialsasTopicMedicalEndpointDeterminationClinicalTrialsasTopic:methods
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1Benefits, challenges and obstacles of adaptive clinical trial designs.
S. Chow, und R. Corey. Orphanet journal of rare diseases, (Januar 2011)6593<m:linebreak></m:linebreak>GR: 2P30 AI064518/AI/NIAID NIH HHS/United States; JID: 101266602; OID: NLM: PMC3248853; 2011/08/22 received; 2011/11/30 accepted; 2011/11/30 aheadofprint; epublish;<m:linebreak></m:linebreak>Tipus d'estudis; Dissenys adaptatius.
vor 2 Jahren von @jepcastel
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ResearchDesign
Humans
DrugIndustry:standards
Dose-ResponseRelationship
UnitedStatesFoodandDrugAdministration
DataInterpretation
DrugIndustry
SampleSize
ClinicalTrialsasTopic:standards
Statistical
ClinicalTrialsasTopic
TreatmentOutcome
EndpointDetermination
ClinicalTrialsasTopic:methods
UnitedStates
Drug
ResearchDesignHumansDrugIndustry:standardsDose-ResponseRelationshipUnitedStatesFoodandDrugAdministrationDataInterpretationDrugIndustrySampleSizeClinicalTrialsasTopic:standardsStatisticalClinicalTrialsasTopicTreatmentOutcomeEndpointDeterminationClinicalTrialsasTopic:methodsUnitedStatesDrug
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1Biomarkers and surrogate endpoints in clinical trials.
T. Fleming, und J. Powers. Statistics in medicine, 31 (25): 2973-84 (November 2012)6717<m:linebreak></m:linebreak>Mesures de resultats; Surrogate endpoints; RCT.
vor 2 Jahren von @jepcastel
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ReproducibilityofResults
OutcomeandProcessAssessment(HealthCare)
ResearchDesign
Humans
BiologicalMarkers
ClinicalTrialsasTopic
EndpointDetermination
ReproducibilityofResultsOutcomeandProcessAssessment(HealthCare)ResearchDesignHumansBiologicalMarkersClinicalTrialsasTopicEndpointDetermination
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1Blinded sample size reestimation with count data: methods and applications in multiple sclerosis.
T. Friede, und H. Schmidli. Statistics in medicine, 29 (10): 1145-56 (Mai 2010)5506<m:linebreak></m:linebreak>JID: 8215016; aheadofprint;<m:linebreak></m:linebreak>Sample size; Count data.
vor 2 Jahren von @jepcastel
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PoissonDistribution
Relapsing-Remitting
Humans
Relapsing-Remitting:pathology
PilotProjects
EpidemiologicResearchDesign
Relapsing-Remitting:drugtherapy
DataInterpretation
EndpointDetermination:methods
MultipleSclerosis
TimeFactors
Double-BlindMethod
SampleSize
Single-BlindMethod
Statistical
ClinicalTrialsasTopic
BinomialDistribution
EndpointDetermination
ClinicalTrialsasTopic:methods
PoissonDistributionRelapsing-RemittingHumansRelapsing-Remitting:pathologyPilotProjectsEpidemiologicResearchDesignRelapsing-Remitting:drugtherapyDataInterpretationEndpointDetermination:methodsMultipleSclerosisTimeFactorsDouble-BlindMethodSampleSizeSingle-BlindMethodStatisticalClinicalTrialsasTopicBinomialDistributionEndpointDeterminationClinicalTrialsasTopic:methods
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1Challenges to multiple testing in clinical trials.
H. Hung, und S. Wang. Biometrical journal. Biometrische Zeitschrift, 52 (6): 747-56 (Dezember 2010)5861<m:linebreak></m:linebreak>Comparacions múltiples.
vor 2 Jahren von @jepcastel
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SocialControl
TimeFactors
ResearchDesign
Humans
Statistical
Formal
ClinicalTrialsasTopic
DataInterpretation
TreatmentOutcome
EndpointDetermination
ClinicalTrialsasTopic:methods
SocialControlTimeFactorsResearchDesignHumansStatisticalFormalClinicalTrialsasTopicDataInterpretationTreatmentOutcomeEndpointDeterminationClinicalTrialsasTopic:methods
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1Clinical effectiveness in cardiovascular trials in relation to the importance to the patient of the end-points measured.
R. Bowater, und R. Lilford. Journal of evaluation in clinical practice, 17 (4): 547-53 (August 2011)6317<m:linebreak></m:linebreak>CI: (c) 2010; JID: 9609066; 2010/07/13 aheadofprint; ppublish;<m:linebreak></m:linebreak>Comparacions múltiples; Composite endpoints; CV.
vor 2 Jahren von @jepcastel
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RCT
CardiovascularDiseases:prevention&control
Humans
RandomizedControlledTrialsasTopic:statistics
DatabasesasTopic
BiologicalMarkers
CardiovascularDiseases:therapy
TreatmentOutcome
EndpointDetermination
CardiovascularDiseases
RCTCardiovascularDiseases:prevention&controlHumansRandomizedControlledTrialsasTopic:statisticsDatabasesasTopicBiologicalMarkersCardiovascularDiseases:therapyTreatmentOutcomeEndpointDeterminationCardiovascularDiseases
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1Evaluating patient-centered outcomes in the randomized controlled trial and beyond: informing the future with lessons from the past.
C. Booth. Clinical cancer research : an official journal of the American Association for Cancer Research, 16 (24): 5963-71 (Dezember 2010)6080<m:linebreak></m:linebreak>CI: (c)2010; JID: 9502500; ppublish;.
vor 2 Jahren von @jepcastel
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RCT
ResearchDesign
Humans
ProfessionalPractice:trends
Investigational:trends
MedicalOncology
ResearchDesign:standards
ResearchDesign:trends
Investigational:methods
Patient-CenteredCare
OutcomeAssessment(HealthCare)
Therapies
ProfessionalPractice
MedicalOncology:methods
MedicalOncology:trends
Patient-CenteredCare:trends
TreatmentOutcome
Investigational
EndpointDetermination
Patient-CenteredCare:methods
RandomizedControlledTrialsasTopic:trends
RCTResearchDesignHumansProfessionalPractice:trendsInvestigational:trendsMedicalOncologyResearchDesign:standardsResearchDesign:trendsInvestigational:methodsPatient-CenteredCareOutcomeAssessment(HealthCare)TherapiesProfessionalPracticeMedicalOncology:methodsMedicalOncology:trendsPatient-CenteredCare:trendsTreatmentOutcomeInvestigationalEndpointDeterminationPatient-CenteredCare:methodsRandomizedControlledTrialsasTopic:trends
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1Individual and composite study endpoints: separating the wheat from the chaff.
R. Goldberg, J. Gore, B. Barton, und J. Gurwitz. The American journal of medicine, 127 (5): 379-84 (Mai 2014)Comparacions múltiples; Composite endpoints; Introductori.
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Cost-BenefitAnalysis
SampleSize
ResearchDesign
Humans
ClinicalTrialsasTopic:standards
ClinicalTrialsasTopic:trends
OutcomeAssessment(HealthCare)
ClinicalTrialsasTopic
ProspectiveStudies
TreatmentOutcome
EndpointDetermination
Cost-BenefitAnalysisSampleSizeResearchDesignHumansClinicalTrialsasTopic:standardsClinicalTrialsasTopic:trendsOutcomeAssessment(HealthCare)ClinicalTrialsasTopicProspectiveStudiesTreatmentOutcomeEndpointDetermination
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1Making sense of noninferiority: a clinical and statistical perspective on its application to cardiovascular clinical trials.
S. Kaul, und G. Diamond. Progress in cardiovascular diseases, 49 (4): 284-99 (2007)5396<m:linebreak></m:linebreak>LR: 20071115; JID: 0376442; 0 (Anticoagulants); 0 (Platelet Aggregation Inhibitors); RF: 39; ppublish;<m:linebreak></m:linebreak>Tests d'equivalència.
vor 2 Jahren von @jepcastel
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Anticoagulants
LikelihoodFunctions
RCT
ResearchDesign
Humans
RandomizedControlledTrialsasTopic:statistics
Anticoagulants:therapeuticuse
BayesTheorem
DataInterpretation
PlateletAggregationInhibitors
CardiovascularDiseases:drugtherapy
OddsRatio
Statistical
TreatmentOutcome
EndpointDetermination
PlateletAggregationInhibitors:therapeuticuse
CardiovascularDiseases
AnticoagulantsLikelihoodFunctionsRCTResearchDesignHumansRandomizedControlledTrialsasTopic:statisticsAnticoagulants:therapeuticuseBayesTheoremDataInterpretationPlateletAggregationInhibitorsCardiovascularDiseases:drugtherapyOddsRatioStatisticalTreatmentOutcomeEndpointDeterminationPlateletAggregationInhibitors:therapeuticuseCardiovascularDiseases
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1Managing the resource demands of a large sample size in clinical trials: can you succeed with fewer subjects?
A. Keech, und V. Gebski. The Medical journal of Australia, 177 (8): 445-7 (Oktober 2002)5110<m:linebreak></m:linebreak>LR: 20071115; JID: 0400714; CIN: Med J Aust. 2003 Apr 7;178(7):356-7; author reply 357-8. PMID: 12670287; 2002/09/23 received; 2002/09/24 accepted; ppublish;.
vor 2 Jahren von @jepcastel
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SampleSize
PatientSelection
Humans
PatientCompliance
ClinicalTrialsasTopic
EndpointDetermination
ClinicalTrialsasTopic:methods
SampleSizePatientSelectionHumansPatientComplianceClinicalTrialsasTopicEndpointDeterminationClinicalTrialsasTopic:methods
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1Mediators, moderators, and modulators of causal effects in clinical trials--Dynamically Modified Outcomes (DYNAMO) in health-related quality of life.
G. Donaldson, Y. Nakamura, und C. Moinpour. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 18 (2): 137-45 (März 2009)5144<m:linebreak></m:linebreak>JID: 9210257; 2008/04/21 received; 2008/12/21 accepted; 2009/01/20 aheadofprint; ppublish;.
vor 2 Jahren von @jepcastel
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QualityofLife
RCT
Humans
Statistical
Bias(Epidemiology)
DataInterpretation
EndpointDetermination
QualityofLifeRCTHumansStatisticalBias(Epidemiology)DataInterpretationEndpointDetermination
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1Minimizing bias in randomized trials: the importance of blinding.
B. Psaty, und R. Prentice. JAMA : the journal of the American Medical Association, 304 (7): 793-4 (August 2010)5720<m:linebreak></m:linebreak>GR: CA53996/CA/NCI NIH HHS/United States; GR: HL078888/HL/NHLBI NIH HHS/United States; GR: HL080295/HL/NHLBI NIH HHS/United States; GR: HL085251/HL/NHLBI NIH HHS/United States; GR: HL087652/HL/NHLBI NIH HHS/United States; JID: 7501160; ppublish;<m:linebreak></m:linebreak>Emmascarament.
vor 2 Jahren von @jepcastel
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Double-BlindMethod
RCT
RandomizedControlledTrialsasTopic:statistics
Single-BlindMethod
Bias(Epidemiology)
TreatmentOutcome
EndpointDetermination
Double-BlindMethodRCTRandomizedControlledTrialsasTopic:statisticsSingle-BlindMethodBias(Epidemiology)TreatmentOutcomeEndpointDetermination
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1Multiplicity in randomised trials I: endpoints and treatments.
K. Schulz, und D. Grimes. Lancet, 365 (9470): 1591-5 (2005)3818<m:linebreak></m:linebreak>Comparacions múltiples.
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RCT
ResearchDesign
Statistical
DataInterpretation
EndpointDetermination
RCTResearchDesignStatisticalDataInterpretationEndpointDetermination
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1Non-inferiority randomized trials, an issue between science and ethics: the case of the SYNTAX study.
V. Mantovani, V. Lepore, A. Mira, und E. Berglin. Scandinavian cardiovascular journal : SCJ, 44 (6): 321-4 (Dezember 2010)6316<m:linebreak></m:linebreak>JID: 9708377; 2010/10/07 aheadofprint; ppublish;<m:linebreak></m:linebreak>Tests d'equivalència.
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CoronaryArteryDisease:surgery
RCT
Angioplasty
ResearchDesign
Europe
Humans
Balloon
RandomizedControlledTrialsasTopic:ethics
Research
DataInterpretation
Ethics
CoronaryArteryDisease:therapy
CoronaryArteryDisease
Coronary
Statistical
CoronaryArteryBypass
EndpointDetermination
CoronaryArteryDisease:surgeryRCTAngioplastyResearchDesignEuropeHumansBalloonRandomizedControlledTrialsasTopic:ethicsResearchDataInterpretationEthicsCoronaryArteryDisease:therapyCoronaryArteryDiseaseCoronaryStatisticalCoronaryArteryBypassEndpointDetermination
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1Noninferiority hypotheses and choice of noninferiority margin.
T. Ng. Statistics in medicine, 27 (26): 5392-406 (November 2008)4579<m:linebreak></m:linebreak>PUBM: Print; JID: 8215016; ppublish;<m:linebreak></m:linebreak>Tests d'equivalència.
vor 2 Jahren von @jepcastel
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ResearchDesign
Humans
Statistical
ClinicalTrialsasTopic
DataInterpretation
ComputerSimulation
EndpointDetermination
EndpointDetermination:methods
ClinicalTrialsasTopic:methods
ProportionalHazardsModels
ResearchDesignHumansStatisticalClinicalTrialsasTopicDataInterpretationComputerSimulationEndpointDeterminationEndpointDetermination:methodsClinicalTrialsasTopic:methodsProportionalHazardsModels
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1Optimal Use of the Non-Inferiority Trial Design
F. Angeli, P. Verdecchia, G. Vaudo, S. Masnaghetti, und G. Reboldi. Pharmaceutical Medicine, 34 (3): 159-165 (Juni 2020)Tests d'equivalència; Introductori; Critical appraisal.
vor 2 Jahren von @jepcastel
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EquivalenceTrialsasTopic*
NationalLibraryofMedicine
Review
PubMedAbstract
pmid:32277352
Humans
GianpaoloReboldi
DataInterpretation
NIH
NLM
doi:10.1007/s40290-020-00334-z
FabioAngeli
NationalInstitutesofHealth
Statistical
DataAccuracy
TreatmentOutcome
PaoloVerdecchia
EndpointDetermination
NationalCenterforBiotechnologyInformation
MEDLINE
NCBI
ResearchDesign*
EquivalenceTrialsasTopic*NationalLibraryofMedicineReviewPubMedAbstractpmid:32277352HumansGianpaoloReboldiDataInterpretationNIHNLMdoi:10.1007/s40290-020-00334-zFabioAngeliNationalInstitutesofHealthStatisticalDataAccuracyTreatmentOutcomePaoloVerdecchiaEndpointDeterminationNationalCenterforBiotechnologyInformationMEDLINENCBIResearchDesign*
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1Patient reported outcomes as endpoints in medical research.
D. Fairclough. Statistical methods in medical research, 13 (2): 115-38 (April 2004)4067<m:linebreak></m:linebreak>Mesures de resultats.
vor 2 Jahren von @jepcastel
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MigraineDisorders
BiomedicalResearch
Double-BlindMethod
SelfDisclosure
Humans
EndpointDetermination:statistics&numericaldat
LongitudinalStudies
MigraineDisorders:prevention&control
TreatmentOutcome
EndpointDetermination
UnitedStates
MigraineDisordersBiomedicalResearchDouble-BlindMethodSelfDisclosureHumansEndpointDetermination:statistics&numericaldatLongitudinalStudiesMigraineDisorders:prevention&controlTreatmentOutcomeEndpointDeterminationUnitedStates
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1Pitfalls of using composite primary end points in the presence of competing risks.
L. Mell, und J. Jeong. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 28 (28): 4297-9 (Oktober 2010)Comparacions múltiples.
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Neoplasms:mortality
RCT
ResearchDesign
Humans
SurvivalAnalysis
Neoplasms:therapy
Risk
Probability
ComparativeEffectivenessResearch
Neoplasms
EndpointDetermination
Neoplasms:mortalityRCTResearchDesignHumansSurvivalAnalysisNeoplasms:therapyRiskProbabilityComparativeEffectivenessResearchNeoplasmsEndpointDetermination
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1A concise display of multiple end points for benefit-risk assessment.

1An introduction to competing risks analysis.

1Assessment of futility in clinical trials.

1Benefits, challenges and obstacles of adaptive clinical trial designs.

1Biomarkers and surrogate endpoints in clinical trials.

1Blinded sample size reestimation with count data: methods and applications in multiple sclerosis.

1Challenges to multiple testing in clinical trials.

1Clinical effectiveness in cardiovascular trials in relation to the importance to the patient of the end-points measured.

1Evaluating patient-centered outcomes in the randomized controlled trial and beyond: informing the future with lessons from the past.

1Individual and composite study endpoints: separating the wheat from the chaff.

1Making sense of noninferiority: a clinical and statistical perspective on its application to cardiovascular clinical trials.

1Managing the resource demands of a large sample size in clinical trials: can you succeed with fewer subjects?

1Mediators, moderators, and modulators of causal effects in clinical trials--Dynamically Modified Outcomes (DYNAMO) in health-related quality of life.

1Minimizing bias in randomized trials: the importance of blinding.

1Multiplicity in randomised trials I: endpoints and treatments.

1Non-inferiority randomized trials, an issue between science and ethics: the case of the SYNTAX study.

1Noninferiority hypotheses and choice of noninferiority margin.

1Optimal Use of the Non-Inferiority Trial Design

1Patient reported outcomes as endpoints in medical research.

1Pitfalls of using composite primary end points in the presence of competing risks.

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