The Empirica™ Signal application is a web-based analysis environment for generating statistical scores for combinations of drugs and events in a drug safety database, and for detecting signals (unexpected associations of drugs and events). The source data may be public data, such as the data in the Adverse Event Reporting System (AERS); Vaccine Adverse Event Reporting System (VAERS); WHO Vigibase ADR (Adverse Drug Reaction) databases; or your organization's proprietary drug safety database.