Editorial. The use of antiepileptic drugs (AED) is common in women of childbearing age. One study1 reported that prenatal AED exposure occurred in 2.19% of all pregnancies in the United States. In the past decade, findings have highlighted that it is no longer sufficient to only consider the association between first-trimester exposure and the risk for structural teratogenicity, because prenatal AED exposure throughout the entire pregnancy can have long-term negative consequences on neurodevelopment. The published studies are limited in scope but have consistently reported that valproate prenatal exposure is associated with lower scores on neuropsychometric batteries during early childhood,2,3 while prenatal exposure to carbamazepine and lamotrigine monotherapies is associated with relatively normal scores. Risks associated with most other AEDs have not been adequately studied, to my knowledge.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Editorial. Status epilepticus (SE) is a very common neurological emergency in children.1,2 Refractory convulsive SE (RCSE) is characterized by the persistence of convulsive seizures or evolution of the convulsive seizure to nonconvulsive seizures event after initial antiseizure treatment.3 Children presenting in RCSE account for a high percentage of morbidity and mortality.3-5 In one study, the mortality was 32% for children with RCSE.4. . Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
The Medicines and Healthcare Products Regulatory Agency (MHRA) has banned the antiepileptic drug sodium valproate in the UK in all women of childbearing potential who are not enrolled in a pregnancy prevention programme.
The regulator said that it had made the decision to protect public health and in close collaboration with professional bodies, NHS organisations, and patient and campaign groups.
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a pioneering medical team in Cornwall developed an app to allow people with epilepsy to monitor their condition and health risk. The app has already won many prestigious awards in the UK and USA, including the 2016 HSJ Patient Safety award, 2016 BMJ Neurology awards, 2015 International League Against Epilepsy (ILAE) awards and 2015 Epilepsy Foundation US.
Among patients with inflammatory bowel disease, what is the incidence of Parkinson disease, and does earlier exposure to anti–tumor necrosis factor therapy mitigate their risk of Parkinson disease?. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
What is the risk and medication contribution to cause-specific unnatural mortality in people with epilepsy?. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Surveys of patients with multiple sclerosis report that most are interested in modifying their diet and using supplements to potentially reduce the severity and symptoms of the disease. This review provides an updated overview of the current state of evidence for the role that vitamins and dietary supplements play in multiple sclerosis and its animal models, with an emphasis on recent studies, and addresses biological plausibility and safety issues.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Open access. The aim was to capture interdisciplinary expertise from a large group of clinicians, reflecting practice from across the UK and further, to inform subsequent development of a national consensus guidance for optimal management of idiopathic intracranial hypertension (IIH).
Open access. Sudden unexpected death in epilepsy (SUDEP) in children, although rare, needs critical attention given the tragic nature and devastating consequences for families and caregivers. True incidence is unknown and risk factors are not completely understood, more so in children compared with adults. A focused narrative review of available studies on paediatric SUDEP was undertaken to comprehend its risk factors and to develop strategies to recognise and where possible modify SUDEP risk and ultimately reduce incidence.
Open access. To investigate the effects of continuous intrathecal baclofen (ITB) therapy in children with cerebral palsy (CP) and other neurological conditions..
We investigated long-term (to 25 years) seizure prognosis and survival in people with newly diagnosed epilepsy in the community. We explored whether prognosis is different in those with epilepsy (>2 unprovoked seizures) and those with a single seizure at presentation. To read the full article, log in using your NHS OpenAthens details
Psychogenic non-epileptic seizures (PNES) are involuntary paroxysmal events that are unaccompanied by epileptiform EEG discharges. We hypothesised that PNES are a disorder of distributed brain networks resulting from their functional disconnection.The disconnection may underlie a dissociation mechanism that weakens the influence of unconsciously presented traumatising information but exerts maladaptive effects leading to episodic failures of behavioural control manifested by psychogenic ‘seizures’. To read the full article, log in using your NHS OpenAthens details
Conclusions The findings indicate how maximising quality in social care delivery for people with Parkinson's disease can impact on health and well-being. Long-term or short-term benefits may result in prevented events and reductions in health and social care resource. Health professionals can be instrumental in early detection of and signposting to social care.
Mindfulness-based therapy can benefit people with drug-resistant epilepsy. This article concerns 60 people, each receiving either four bi-weekly sessions of therapy or social support. They were included in randomised controlled trials to assess their quality of life in epilepsy inventory (QOLEI) score level, seizure patterns, mood levels and neurocognitive functions. Login using your SSSFT NHS OpenAthens for full text. SSOTP - request a copy of the article from the library - http://bit.ly/1Xyazai
Physical speech problems are often less of a problem for people with Parkinson’s disease than the cognitive ability to keep up with conversations. To read the full article, log in using your NHS OpenAthens details
First-time stroke survivors and family caregivers are more likely to engage with rehabilitation programmes if they are led by nurses, a new study suggests. To read the full article, log in using your NHS Athens
Objectives The study sought to describe whether psychotropic medication may have long-term side effects in patients with stroke compared with controls. Open Access Article
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Objectives: To systematically review the evidence investigating the effectiveness of resistance training on strength and physical function in people with Parkinson’s disease. Conclusion: This review demonstrates that moderate intensity progressive resistance training, 2-3 times per week over 8-10 weeks can result in significant strength, balance and motor symptoms gains in people with early to moderate Parkinson’s disease. [ABSTRACT FROM AUTHOR] To read the full article, log in using your NHS Athens
Aims: To describe the relationship between perceived swallowing difficulties in people with Parkinson's disease with disease-specific measures, carers' perceptions of swallowing problems and control participant responses. Method: In total, 119 people with Parkinson's disease, their carers and matched controls answered a specifically prepared functional swallowing changes questionnaire. People with Parkinson's completed a water-swallowing test. Motor status, cognition and mood were also assessed. Results: People with Parkinson's disease scored poorer than controls (p < 0.001) on the questionnaire. Those reporting swallowing problems scored poorer than those who did not (p < 0.01). However, of 74 people with Parkinson's who perceived no swallowing problem, 32 fell below the 50th percentile on the water-swallowing test, while 41 fell below cut-off scores on the questionnaire. There was a weak correlation between drinking speeds and questionnaire totals. Carers' evaluations correlated with their partners' (r = 0.796) but they perceived changes as less severe (p < 0.03). Conclusions: Despite reduced swallowing efficiency, some people with Parkinson's can successfully compensate. A sizeable proportion, however, remain unaware of swallowing problems when asked simply 'Do you have a problem?', but indicate difficulties with more specific questions. The present questionnaire provides a guide for gaining such insights for diagnosis, education and outcomes. To read the full article, log in using your NHS Athens
Objective: To enhance participation post stroke through a structured, community-based program. Conclusions: Community-based programs targeting participation are feasible and effective, but stroke survivors require time to achieve meaningful gains. [ABSTRACT FROM AUTHOR] To read the full article, log in using your NHS Athens
Environmental factors may play a far greater role in the onset of multiple sclerosis (MS) than previously thought, shows a study that compared rates of the condition in immigrants to east London with those of their ancestral groups. To read the full article, log in using your NHS OpenAthens details
This commentary is on the original article by Sakzewski et al.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
This commentary is on the systematic review by López‐Ortiz et al.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Dystonia is a challenging neurological symptom found in paediatric palliative care (PPC).1 While well defined as a movement disorder characterised by sustained or intermittent muscle contractions associated with abnormal movement and posturing, dystonia is less well recognised and identified by clinicians.2 A wide range of therapies exist but consensus is often lacking regarding choice of treatment. No studies to date have analysed differences in management of dystonia between palliative care and neurology services.. To read the full article, log in using your NHS OpenAthens details.
A sequential desk-top task was applied, whose performance required the spatiotemporal attention function step by step, to patients after stroke. The relationship between the sequential task and conventional assessments of cognitive function was also assessed. To read the full article, log in using your MPFT NHS OpenAthens details
In this multicentre open-label trial, we compared behavioural and neuropsychiatric symptoms in Parkinson’s disease (PD) patients with impulse control disorders (ICD) treated with dopamine agonists before and 12 weeks after substituting dopamine agonists with an equivalent dose of levodopa/carbidopa slow-release formulation.. To read the full article, log in using your NHS OpenAthens details.
Open access. Letter. Clinical syndromes associated with frontotemporal lobar degeneration (FTLD) pathology may overlap. Progressive supranuclear palsy syndrome (PSPs) may co-occur with behavioural frontotemporal dementia (bvFTD), non-fluent aphasia (nfPPA) and corticobasal syndrome.1 This is unsurprising, given each syndrome’s association with tau pathology. We describe here a less anticipated association: between PSPs and semantic dementia (SD).
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We explored factors associated with pain and its severity in a population cohort of young people with bilateral cerebral palsy, comparing parent/carer and young people self‐reports.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
To investigate potential harm and benefits of antiepileptic drugs (AED) given prophylactically to prevent de novo brain tumour-related epilepsy after craniotomy.. To read the full article, log in using your NHS OpenAthens details.
The aim of this study was to disentangle mechanisms of epileptogenesis in monogenic epilepsies in children. We reviewed paediatric monogenic epilepsies excluding brain malformation or an inborn error of metabolism, but including the gene function whether there is loss‐of‐function or gain‐of‐function, age at gene expression when available, and associated epilepsy syndrome.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
This review summarizes studies that examined the effectiveness of cannabinoids in treating spasticity, with a focus on understanding the relevance of the existing evidence to paediatric populations. MEDLINE, Embase, PsycINFO, and the Cochrane Library were searched to identify studies that examined the use of cannabinoids in spasticity. We identified 32 studies in adult and paediatric populations. Results were summarized by condition, with adult and paediatric studies considered separately. There is evidence from randomized controlled clinical trials that cannabinoids are more effective than placebo in reducing symptoms of spasticity in adults with multiple sclerosis....... To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Annual epilepsy reviews can provide substantial benefits for people living with epilepsy, and practice nurses are ideally placed to undertake them. Pamela Mantri explains how a review can be undertaken and signposts useful resources for more information. To read the full article, log in using your MPFT NHS OpenAthens details.
This commentary is on the original article by Whitney et al. To view this paper visit https://doi.org/10.1111/dmcn.14175.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Open access. To examine the relationships between upper limb impairments and independence in self‐care (ISC) in children with unilateral cerebral palsy (CP).
This commentary is on the original article by Ryan et al. To view this paper visit https://doi.org/10.1111/dmcn.14177.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
The development of a nurse‐led approach to managing epilepsy in adults with an intellectual disability (ID) offers the potential of improved outcomes and lower costs of care. We undertook a cluster randomised trial to assess the impact on costs and outcomes of the provision of ID nurses working to a designated epilepsy nurse competency framework. Here, we report the impact of the intervention on costs.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Previous studies have demonstrated a strong latitudinal gradient in multiple sclerosis (MS) prevalence. Herein, we present a meta-analysis of the latitudinal gradient of MS prevalence including studies published since our 2011 review, seeking to assess the latitudinal gradient and whether it has changed since our previous analysis.. To read the full article, log in using your NHS OpenAthens details.
Free access. Dementia is a common, debilitating feature of late Parkinson’s disease (PD). PD dementia (PDD) is associated with α-synuclein propagation, but coexistent Alzheimer’s disease (AD) pathology may coexist. Other pathologies (cerebrovascular, transactive response DNA-binding protein 43 (TDP-43)) may also influence cognition. We aimed to describe the neuropathology underlying dementia in PD.
To conduct a review of research literature on the use of dance and movement with music (rhythmic auditory stimulation [RAS]) in the neurorehabilitation of children and adults with cerebral palsy (CP).. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Psychological Services (Nov 1, 2018). DOI:10.1037/ser0000208
This study evaluated whether a history of traumatic brain injury (TBI) was associated with increased risk for recent suicidal ideation (SI) after accounting for demographics, depression, posttraumatic stress disorder (PTSD), and sleep quality. In terms of increased risk, we hypothesized that a history of lifetime TBI would be associated with increased recent SI when compared with no history of TBI; multiple injuries were also evaluated. The sample included Iraq and Afghanistan war-era veterans (n = 838) who served in the United States military since 9/2001 and completed a structured TBI interview.. To read the full article, log in using your MPFT NHS OpenAthens details.
Cerebral palsy (CP) is not a disease, but a neurological syndrome, a combination of signs and symptoms, some of which may occur in neurodegenerative or metabolic disorders, particularly those with an onset in the first 2 years of life. There are many different causes of the syndrome. All children with CP should undergo brain MRI, even with an identified antenatal or perinatal insult. Children with CP should be referred to a paediatric neurologist or a clinical geneticist, or both, if appropriate and particularly in the absence of a known perinatal cerebral insult, with brain MRI that is reported to be normal, a progression in, or new, signs or where there is a reported ‘family history of CP’. Finally, a few of the CP syndromes may be readily treatable and potentially prevent irreversible neurological and cognitive impairment.. To read the full article, log in using your NHS OpenAthens details.
The incidence of epilepsy is higher in older age than at any other period of life. Stroke, dementia, and hypertension are associated with late-onset epilepsy; however, the role of other vascular and lifestyle factors remains unclear.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
In 2017, the International Panel on Diagnosis of Multiple Sclerosis revised the McDonald 2010 criteria for the diagnosis of multiple sclerosis (MS). The new criteria are easier to apply and could lead to more and earlier diagnoses. It is important to validate these criteria globally for their accuracy in clinical practice.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Several non-motor features may individually contribute to identify prodromal Parkinson’s disease (PD), but little is known on how they interact.. To read the full article, log in using your NHS OpenAthens details.
This early study shows some promise for this new T-cell-based treatment.
This treatment has been used in people with primary or secondary progressive MS.
These forms of the condition are hard to treat, so new treatments would be very welcome.
This first stage of testing is largely about making sure the treatment is safe enough to allow further studies to be carried out in more people.
Neurogenerative diseases manifest in an abnormal build-up of proteins in the brain. These often include misfolded proteins, such as the tangles of the protein tau found in Alzheimer’s disease and the abnormal cluster of proteins that form the Lewy bodies associated with Parkinson’s disease. These changes can lead to inflammation, synaptic insufficiency and cell death. To read the full article, log in using your MPFT NHS OpenAthens details.
To identify developmental trajectories of hand function in infants aged 3 months to 12 months with unilateral cerebral palsy (CP).. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Several features of amyotrophic lateral sclerosis (ALS) impact on sexuality and intimate relationship; however, the issue has received poor attention so far. We performed a systematic literature review in order to provide an up-to-date account of sexuality in ALS.. To read the full article, log in using your NHS OpenAthens details.
Open access. Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease of motor neurons with a median survival of 2 years. Familial ALS has a younger age of onset than apparently sporadic ALS. We sought to determine whether this younger age of onset is a result of ascertainment bias or has a genetic basis.
Gait disturbances are frequent side effects occurring during chronic thalamic deep brain stimulation (DBS) in patients with essential tremor (ET). Adapting stimulation settings to shorter pulse widths has been shown to reduce side effects of subthalamic DBS. Here, we assess how a reduction of pulse width changes gait performance of affected patients.. To read the full article, log in using your NHS OpenAthens details.
Psychosis of epilepsy (POE) occurs more frequently in temporal lobe epilepsy, raising the question as to whether abnormalities of the hippocampus are aetiologically important. Despite decades of investigation, it is unclear whether hippocampal volume is reduced in POE, perhaps due to small sample sizes and methodological limitations of past research.. To read the full article, log in using your NHS OpenAthens details.
Seizures and movement disorders (MDs) are distinct neurological conditions presenting with abnormal movements. Despite sharing an overlap in phenomenology, these movements have different origins. In order to explore the overlaps and the narrow boundaries between these two conditions, we performed a review of the literature to explore the risk of seizures in MDs. We discussed the mimics and chameleons including MDs that look like seizure (eg, paroxysmal dyskinesia, status dystonicus) and seizures that look like MDs (eg, epilepsia partialis continua, nocturnal frontal lobe epilepsy). Additionally, we examined the therapeutic challenges as well as the anatomical and chemical pathways relevant in the interplay between epilepsy and MDs. Finally, we proposed an algorithm to guide clinicians towards the final diagnosis of conditions characterised by the co-occurrence of MDs and seizures.. To read the full article, log in using your NHS OpenAthens details.
Phenytoin is the current standard of care for second-line treatment of paediatric convulsive status epilepticus after failure of first-line benzodiazepines, but is only effective in 60% of cases and is associated with considerable adverse effects. A newer anticonvulsant, levetiracetam, can be given more quickly, is potentially more efficacious, and has a more tolerable adverse effect profile. We aimed to determine whether phenytoin or levetiracetam is the superior second-line treatment for paediatric convulsive status epilepticus.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
In the management of neurological diseases, the identification and quantification of axonal damage could allow for the improvement of diagnostic accuracy and prognostic assessment. Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. Its levels increase in cerebrospinal fluid (CSF) and blood proportionally to the degree of axonal damage in a variety of neurological disorders, including inflammatory, neurodegenerative, traumatic and cerebrovascular diseases. New immunoassays able to detect biomarkers at ultralow levels have allowed for the measurement of NfL in blood, thus making it possible to easily and repeatedly measure NfL for monitoring diseases’ courses. Evidence that both CSF and blood NfL may serve as diagnostic, prognostic and monitoring biomarkers in neurological diseases is progressively increasing, and NfL is one of the most promising biomarkers to be used in clinical and research setting in the next future. Here we review the most important results on CSF and blood NfL and we discuss its potential applications and future directions.. To read the full article, log in using your NHS OpenAthens details.
Open access. Non-invasive neuromodulation therapies for migraine and cluster headache are a practical and safe alternative to pharmacologics. Comparisons of these therapies are difficult because of the heterogeneity in study designs. In this systematic review of clinical trials, the scientific rigour and clinical relevance of the available data were assessed to inform clinical decisions about non-invasive neuromodulation.
Open access. The prevalence and definition of benign multiple sclerosis (BMS) remain controversial. Most definitions are based on the Expanded Disability Status Scale (EDSS), not encompassing the wider impact of disease. The explanation for favourable outcomes remains unclear. We aim to provide a detailed characterisation of patients with low EDSS scores at long disease durations.
To investigate potential harm and benefits of antiepileptic drugs (AED) given prophylactically to prevent de novo brain tumour-related epilepsy after craniotomy.. To read the full article, log in using your NHS OpenAthens details.
Open access. Functional non-epileptic attacks (FNEA) are seizure-like events occurring in the absence of epilepsy. Having had many different names over the years including dissociative convulsions and pseudo-seizures, they now fall in the borderland between neurology and psychiatry, often not accepted by either specialty. However, there is evidence that there is a high rate of psychiatric comorbidity in these patients and therefore it is likely that psychiatrists will come across patients with FNEA and they should know the broad principles of assessment and management.
Open access. Establishing the prevalence of neuropsychiatric symptoms (NPS), quality of life and psychotropic drug use in people aged ≤65 years with acquired brain injury in nursing homes.
To explore the barriers to and facilitators of physical activity for young people with cerebral palsy in specialist schools.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
To assess the role of body mass index (BMI) and of the rate of weight loss as prognostic factors in amyotrophic lateral sclerosis (ALS) and to explore the clinical correlates of weight loss in the early phases of the disease.. To read the full article, log in using your NHS OpenAthens details.
Letter. Understanding the mechanism of psychogenic non-epileptic seizures (PNES) is challenging. A recent review grouped currently hypothesised psychological models into four: (1) traumatic dissociation, (2) hard-wired anxious-arousal responses, (3) conversion defences and (4) conditioned behaviours, but concluded that determining which of these was correct, if any, went far beyond the available evidence.1 . To read the full article, log in using your NHS OpenAthens details.
Free access. Psychosis of epilepsy (POE) occurs more frequently in temporal lobe epilepsy, raising the question as to whether abnormalities of the hippocampus are aetiologically important. Despite decades of investigation, it is unclear whether hippocampal volume is reduced in POE, perhaps due to small sample sizes and methodological limitations of past research.
To develop an easily‐administered metric to quantify gait impairment in children and to assess its use in children with cerebral palsy (CP).. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.
Open access. The high degree of clinical overlap between atypical parkinsonian syndromes (APS) and Parkinson’s disease (PD) makes diagnosis challenging. We aimed to identify novel diagnostic protein biomarkers of APS using multiplex proximity extension assay (PEA) testing.
This narrative review describes a range of techniques invented by patients with Parkinson disease to mitigate gait disorders, including freezing of gait.. Please contact the library to request a copy of this article - http://bit.ly/2HjNDf3
Neuro Patience presents the findings of the 2018/19 National Neurology Patient Experience Survey. The report covers three main themes – accessible, personalised and holistic care and support (which includes social care, mental health and financial security). Overall the 2018/19 results show that people’s experiences remain poor.
Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is one of the major causes of intractable epilepsy. It may require a multidisciplinary treatment approach. Many causative factors, including perinatal hypoxia, trauma and genetic influences, have been suggested. Although autoimmunity against neuronal cells has recently been recognised to play a supportive role in its development, very few researchers or clinicians believe that immunological insults are a major cause of MTLE-HS. To read the full article, log in using your NHS OpenAthens details
Parkinson's disease (PD) presents as a progressive neurological disorder characterised by a number of motor and non-motor features.1 Muscle strength and power are reduced in people with PD compared with age-matched individuals.2 Resistance training is beneficial in the general older population3 but has not been rigorously investigated in people with PD. To read the full article, log in using your NHS OpenAthens details
The Neurological Alliance has launched a new patient experience survey for people living with a neurological condition in England. The survey opened on June 30 2016 and will remain open until September 30, and is open to anyone with a neurological condition living in England.
Elevated rates of affective disturbance in children with benign childhood epilepsy with centrotemporal spikes (BCECTS) have been reported. However, it remains unclear how anxiety and depression are related to epilepsy, and it is unknown whether these mood disorders are influenced by the use of antiepileptic drugs. In the present report, we performed a prospective study designed to evaluate affective disorders (anxiety and depression) without the bias of antiepileptic drug treatment in 89 children with BCECTS, based on self-reporting. Furthermore, we sought to determine whether clinical factors, such as age, disease course, seizure frequency, and spike wave index (SWI), were related to the psychological profiles.
Cochrane reviews of physiotherapy (PT) and occupational therapy (OT) for Parkinson’s disease found insufficient evidence of effectiveness, but previous trials were methodologically flawed with small sample size and short-term follow-up.
Parkinson's disease (PD) presents as a progressive neurological disorder characterised by a number of motor and non-motor features.1 Muscle strength and power are reduced in people with PD compared with age-matched individuals.2 Resistance training is beneficial in the general older population3 but has not been rigorously investigated in people with PD.
Aim
To identify the effects of resistance training on physical function and balance in people with PD. To read the full article, log in using your NHS OpenAthens details
A new report published by the Neurological Alliance has found that GPs in England lack confidence in the primary care pathway for people with neurological conditions. New polling of GPs across the country shows low levels of confidence in the ability of local services and systems to manage neurology patients effectively, and widespread concern over unnecessary delays. It also suggests that GPs feel they would benefit from more support to manage people presenting with suspected neurological symptoms.
The innovations selected to join the programme include:
EpSMon: an epilepsy self-management tool which enables patients to monitor their well-being and know when to seek medical support
Serenity Integrated Mentoring (SIM): A collaborative model of care that sees a specialist, trained police officer working within community mental health teams to better mentor, encourage and support some of the most challenging, complex and high risk service users.
Neuropsychiatric symptoms are common in Parkinson's disease (PD) and have a disproportionate impact on quality of life and carer burden. Pharmacological treatment is the main approach in dealing with these symptoms, but it is limited by variable efficacy and risk of drug interactions. Non-pharmacological approaches using the cognitive–behavioural therapy (CBT) model are viable alternatives and in this review paper we summarise the evidence of CBT for three of the most common psychiatric manifestations of PD: depression and anxiety, impulse-control disorders and insomnia. To read the full article, log in using your NHS OpenAthens details.
Patients who have rosacea are at increased risk of developing dementia, particularly Alzheimer’s disease. To read the full article, log in using your NHS OpenAthens details
Migraine is a highly prevalent and disabling neurological disorder associated with a wide range of psychiatric comorbidities. In this manuscript, we provide an overview of the link between migraine and several comorbid psychiatric disorders, including depression, anxiety and post-traumatic stress disorder. We present data on psychiatric risk factors for migraine chronification. We discuss the evidence, theories and methods, such as brain functional imaging, to explain the pathophysiological links between migraine and psychiatric disorders. Finally, we provide an overview of the treatment considerations for treating migraine with psychiatric comorbidities. To read the full article, log in using your NHS OpenAthens details
To estimate symptoms of obstructive sleep apnoea (OSA) and excessive daytime sleepiness (EDS) in children with epilepsy (CWE) compared with those in a typically developing comparison group. CWE are known to have poor sleep, with increased rates of OSA suggested. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Essential facts: There are two types of stroke – around 85% are ischaemic and 15% are haemorrhagic. According to the Stroke Association’s State of the Nation report, published in January 2016, stroke occurs around 152,000 times a year in the UK. It is the fourth largest cause of death in the UK and one of the largest causes of disability. To read the full article, log in using your NHS OpenAthens details
We investigated long-term (to 25 years) seizure prognosis and survival in people with newly diagnosed epilepsy in the community. We explored whether prognosis is different in those with epilepsy (>2 unprovoked seizures) and those with a single seizure at presentation. To read the full article, log in using your NHS OpenAthens details
The global epidemiological shift of disease burden towards long-term conditions means understanding long-term outcomes of cardiovascular disease is increasingly important. More people are surviving stroke to experience its long-term consequences, but outcomes in people living more >10 years after stroke have not been described in detail. To read the full article, log in using your NHS OpenAthens details
Epilepsy care has been identified as a major global issue—and there are many recognised concerns in the UK for children and young people with the condition. A proposed new model could help to increase multisector integration, facilitate better outcomes and offer lessons for improving care of other long-term conditions. To read the full article, log in using your NHS OpenAthens details.
To investigate the feasibility of a full-scale randomised controlled trial of a picture booklet to improve quality of life for people with epilepsy and learning disabilities. Open Access Article
An evaluation has been undertaken of the pilot project to provide a Parkinson’s Disease Nurse Specialist post for two years funded by Parkinson’s UK. - See more at: http://www.sompar.nhs.uk/latest-news/parkinson-s-community-nurse-project-evaluation/#sthash.Ou572RsQ.dpuf
Although lacosamide reduced seizure frequency in people with intractable partial seizures compared with placebo, there was a concomitant increase in adverse events, particularly at the higher doses, which in some ultimately led to treatment withdrawal.
The quality of life (QoL) of informal caregivers of people with Parkinson's disease (PD) (PwP) can be affected by the caring role. Because of cognitive symptoms and diminished activities of daily living, in addition to the management of motor symptoms, carers of PwP and cognitive impairment may experience increased levels of burden and poorer QoL compared with carers of PwP without cognitive impairment. This study aimed to investigate the impact of cognitive impairment in PD upon QoL of carers. Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
There are few reports on the tolerability and efficacy of perampanel, a new antiepileptic drug with a novel mechanism of action, in children and adolescents. We aimed to describe our experience with perampanel add-on and mono-therapy in children with refractory epilepsy. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai